Article
Licensed
Unlicensed
Requires Authentication
Study of Chaperone-Like Activity of Human Haptoglobin: Conformational Changes under Heat Shock Conditions and Localization of Interaction Sites
-
R. Ettrich
Published/Copyright:
June 1, 2005
Abstract
With respect to the mechanism of chaperonelike activity, we examined the behavior of haptoglobin under heat shock conditions. Secondary structure changes during heat treatment were followed by circular dichroism, Raman and infrared spectroscopy. A model of the haptoglobin tetramer, based on its sequence homology with serine proteases and the CCP modules, has been proposed. Sequence regions responsible for the chaperonelike activity were not fully identical with the region that takes part in formation of the hemoglobinhaptoglobin complex. We can postulate the presence of at least two different chaperonebinding sites on each haptoglobin heavy chain.
:
Published Online: 2005-06-01
Published in Print: 2002-10-06
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Biological Chemistry 125th Anniversary
- Kai Simons Felix Hoppe-Seyler Lecturer 2002
- Lipid Rafts in Protein Sorting and Cell Polarity in Budding Yeast Saccharomyces cerevisiae
- Paper of the Year 2001
- RNA-Mediated RNA Degradation in Transgene- and Virus-Induced Gene Silencing
- Immunopharmacology of CpG DNA
- Induction and Regulation of Endogenous Granulocyte Colony-Stimulating Factor Formation
- In the Cellular Garden of Forking Paths: How p38 MAPKs Signal for Downstream Assistance
- The Human Steroid Hydroxylases CYP11B1 and CYP11B2
- Rate-Limiting Steps in Cytochrome P450 Catalysis
- YidC, a Newly Defined Evolutionarily Conserved Protein, Mediates Membrane Protein Assembly in Bacteria
- Vascular Endothelial Growth Factor Receptor Family Genes: When Did the Three Genes Phylogenetically Segregate?
- The TNFTNF Receptor System
- Fast Regulation of Cytochrome P450 Activities by Phosphorylation and Consequences for Drug Metabolism and Toxicity
- Protein Transduction: A Novel Tool for Tissue Regeneration
- NF-κB A Potential Therapeutic Target for Inhibition of Human Cytomegalovirus (Re)activation?
- Three-State Equilibrium of Escherichia coli Trigger Factor
- Binding of a C-Terminal Fragment (Residues 369 to 435) of Vitamin D-Binding Protein to Actin
- The Hyaluronan-Binding Serine Protease from Human Plasma Cleaves HMW and LMW Kininogen and Releases Bradykinin
- Jasmonate-Induced Lipid Peroxidation in Barley Leaves Initiated by Distinct 13-LOX Forms of Chloroplasts
- Real-Time Determination of Telomerase Activity in Cell Extracts Using an Optical Biosensor
- Study of Chaperone-Like Activity of Human Haptoglobin: Conformational Changes under Heat Shock Conditions and Localization of Interaction Sites
Articles in the same Issue
- Biological Chemistry 125th Anniversary
- Kai Simons Felix Hoppe-Seyler Lecturer 2002
- Lipid Rafts in Protein Sorting and Cell Polarity in Budding Yeast Saccharomyces cerevisiae
- Paper of the Year 2001
- RNA-Mediated RNA Degradation in Transgene- and Virus-Induced Gene Silencing
- Immunopharmacology of CpG DNA
- Induction and Regulation of Endogenous Granulocyte Colony-Stimulating Factor Formation
- In the Cellular Garden of Forking Paths: How p38 MAPKs Signal for Downstream Assistance
- The Human Steroid Hydroxylases CYP11B1 and CYP11B2
- Rate-Limiting Steps in Cytochrome P450 Catalysis
- YidC, a Newly Defined Evolutionarily Conserved Protein, Mediates Membrane Protein Assembly in Bacteria
- Vascular Endothelial Growth Factor Receptor Family Genes: When Did the Three Genes Phylogenetically Segregate?
- The TNFTNF Receptor System
- Fast Regulation of Cytochrome P450 Activities by Phosphorylation and Consequences for Drug Metabolism and Toxicity
- Protein Transduction: A Novel Tool for Tissue Regeneration
- NF-κB A Potential Therapeutic Target for Inhibition of Human Cytomegalovirus (Re)activation?
- Three-State Equilibrium of Escherichia coli Trigger Factor
- Binding of a C-Terminal Fragment (Residues 369 to 435) of Vitamin D-Binding Protein to Actin
- The Hyaluronan-Binding Serine Protease from Human Plasma Cleaves HMW and LMW Kininogen and Releases Bradykinin
- Jasmonate-Induced Lipid Peroxidation in Barley Leaves Initiated by Distinct 13-LOX Forms of Chloroplasts
- Real-Time Determination of Telomerase Activity in Cell Extracts Using an Optical Biosensor
- Study of Chaperone-Like Activity of Human Haptoglobin: Conformational Changes under Heat Shock Conditions and Localization of Interaction Sites
