Abstract
The halogens bromine and iodine have similar chemical properties and undergo similar reactions due to their closeness in Group 17 of the periodic chart. There are a number of bromine and iodine radionuclides that have properties useful for diagnosis and therapy of human diseases. The emission properties of radiobromine and radioiodine nuclides with half-lives longer than 1 h are summarized along with properties that make radionuclides useful in PET/SPECT imaging and β/Auger therapy, such that the reader can assess which of the radionuclides might be useful for medical applications. An overview of chemical approaches that have been used to radiolabel molecules with radiobromine and radioiodine nuclides is provided with examples. Further, references to a large variety of different organ/cancer-targeting agents utilizing the radiolabeling approaches described are provided.
Dedicated to: This review is dedicated to Dr. Thomas Ruth for his many contributions to radiohalogen chemistry, and his mentoring/friendship over our careers.
Funding source: Nuclear Physics
Award Identifier / Grant number: DE-SC0018013
Funding statement: Nuclear Physics, Funder Id: http://dx.doi.org/10.13039/100006209, Grant Number: DE-SC0018013.
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©2019 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Editorial: 150 years of the Periodic Table of Chemical Elements
- Part A: Actinides and Transactinides
- Evolution of the periodic table through the synthesis of new elements
- Nuclear and chemical characterization of heavy actinides
- Direct mass measurements and ionization potential measurements of the actinides
- Relativity in the electronic structure of the heaviest elements and its influence on periodicities in properties
- The periodic table – an experimenter’s guide to transactinide chemistry
- Synthesis and properties of isotopes of the transactinides
- Part B: Nuclear Energy
- Homogenous recycling of transuranium elements from irradiated fast reactor fuel by the EURO-GANEX solvent extraction process
- Separation of trivalent actinides and lanthanides using various ‘N’, ‘S’ and mixed ‘N,O’ donor ligands: a review
- Separation of actinides from lanthanides associated with spent nuclear fuel reprocessing in China: current status and future perspectives
- Contamination of Fukushima Daiichi Nuclear Power Station with actinide elements
- Protactinium(V) in aqueous solution: a light actinide without actinyl moiety
- What do we know about actinides-proteins interactions?
- Part C: Medical Radionuclides
- Positron-emitting radionuclides for applications, with special emphasis on their production methodologies for medical use
- Radiochlorine: an underutilized halogen tool
- Radiobromine and radioiodine for medical applications
- Radiochemical aspects of alpha emitting radionuclides for medical application
- Chelators and metal complex stability for radiopharmaceutical applications
Artikel in diesem Heft
- Frontmatter
- Editorial: 150 years of the Periodic Table of Chemical Elements
- Part A: Actinides and Transactinides
- Evolution of the periodic table through the synthesis of new elements
- Nuclear and chemical characterization of heavy actinides
- Direct mass measurements and ionization potential measurements of the actinides
- Relativity in the electronic structure of the heaviest elements and its influence on periodicities in properties
- The periodic table – an experimenter’s guide to transactinide chemistry
- Synthesis and properties of isotopes of the transactinides
- Part B: Nuclear Energy
- Homogenous recycling of transuranium elements from irradiated fast reactor fuel by the EURO-GANEX solvent extraction process
- Separation of trivalent actinides and lanthanides using various ‘N’, ‘S’ and mixed ‘N,O’ donor ligands: a review
- Separation of actinides from lanthanides associated with spent nuclear fuel reprocessing in China: current status and future perspectives
- Contamination of Fukushima Daiichi Nuclear Power Station with actinide elements
- Protactinium(V) in aqueous solution: a light actinide without actinyl moiety
- What do we know about actinides-proteins interactions?
- Part C: Medical Radionuclides
- Positron-emitting radionuclides for applications, with special emphasis on their production methodologies for medical use
- Radiochlorine: an underutilized halogen tool
- Radiobromine and radioiodine for medical applications
- Radiochemical aspects of alpha emitting radionuclides for medical application
- Chelators and metal complex stability for radiopharmaceutical applications