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Recent advances of heterocycle based anticancer hybrids

  • Simranpreet K. Wahan und Pooja A. Chawla EMAIL logo
Veröffentlicht/Copyright: 19. Januar 2022
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Physical Sciences Reviews
Aus der Zeitschrift Physical Sciences Reviews Band 8 Heft 10

Abstract

Cancer is one of the major causes of death across the world. Cancer is a broad word that encompasses a wide range of illnesses that can affect any part of the body. Cancer research has increased understanding of molecular biology and cellular biology, resulting in new cancer therapies. Despite of adverse effects, surgery, radiation, and anticancer medicines are the modern cancer treatments. Keeping in mind the excellent anticancer activity exhibited by various heterocyclics, various medicines with heterocyclic moiety have been developed to identify particular target regions. The chapter aims to discuss new discoveries in the field of anticancer pharmaceuticals comprising the thiazole, pyrazole, oxazole, and triazole rings over the last five years. The proposed anticancer drugs have a lot of future significance due to their high potency.

Keywords: anti-cancer; heterocycles; oxazole; pyrazole; thiazole; triazole and structural activity relationships
Corresponding author: Pooja A. Chawla, Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, Punjab-142001, India, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

References

1. Al-Mulla, A. A review: biological importance of heterocyclic compounds. Der Pharma Chem 2017;9:141–7.Suche in Google Scholar

2. Arora, P, Arora, V, Lamba, HS, Wadhwa, D. Importance of heterocyclic chemistry: a review. Int J Pharmaceut Sci Res 2012;3:2947.Suche in Google Scholar

3. Saini, MS, Kumar, A, Dwivedi, J, Singh, R. A review: biological significances of heterocyclic compounds. Int J Pharm Sci Res 2013;4:66–77.Suche in Google Scholar

4. Kim, S, Kwon, IC, Lee, E. Nanocomplexes for co-delivering a drug and siRNA and uses thereof. U.S. Patent 10. Drnano Co Ltd; 2019, 172, 879.Suche in Google Scholar

5. Ranganatha, VL, Begum, AB, Prashanth, T, Gurupadaswamy, HD, Madhu, SK, Shivakumar, S, et al.. Synthesis and larvicidal properties of benzophenone comprise indole analogues against Culex quinquefasciatus. Drug Invent Today 2013;32:275–80. https://doi.org/10.1016/j.dit.2013.10.001.Suche in Google Scholar

6. Ranganatha, VL, Begum, AB, Prashanth, T, Gurupadaswamy, HD, Madhu, SK, Shivakumar, S, et al.. Synthesis and larvicidal properties of benzophenone comprise indole analogues against Culex quinquefasciatus. Drug Invent Today 2013;5:275–80. https://doi.org/10.1016/j.dit.2013.10.001.Suche in Google Scholar

7. Prashanth, T, Ranganatha, VL, Naveen, P, Gurupadaswamy, HD, Begum, AB, Al-Ghorbani, M, et al.. Synthesis of (4-benzoyl-phenoxy)-acetic acid derivatives and their efficacy as antioxidant agents. Free Radic Antioxidants 2013;3:50–4. https://doi.org/10.1016/j.fra.2013.09.002.Suche in Google Scholar

8. Grimmett, MR. Imidazole and benzimidazole synthesis. Academic Press; 1997.Suche in Google Scholar

9. Balaban, AT, Oniciu, DC, Katritzky, AR. Aromaticity as a cornerstone of heterocyclic chemistry. Chem Rev 2004;104:2777–812. https://doi.org/10.1021/cr0306790.Suche in Google Scholar PubMed

10. Nefzi, A, Ostresh, JM, Houghten, RA. The current status of heterocyclic combinatorial libraries. Chem Rev 1997;97:449–72. https://doi.org/10.1021/cr960010b.Suche in Google Scholar PubMed

11. Tymoshenko, DO. Benzoheteropines with fused pyrrole, furan and thiophene rings. Adv Heterocycl Chem 2008;96:1–80. https://doi.org/10.1016/s0065-2725(07)00001-3.Suche in Google Scholar

12. Shipman, M. Aromatic heterocycles as intermediates in natural product synthesis. Contemp Org Synth 1995;2:1–17. https://doi.org/10.1039/co9950200001.Suche in Google Scholar

13. Dishman, RK, Heath, G, Schmidt, MD, Lee, IM. Physical activity epidemiology. USA: Human Kinetics; 2021.Suche in Google Scholar

14. Najar, IA, Kankala, RK, Johri, RK. Targeted cancer therapies: an overview. Int J Life Sci 2012;6:61–73. https://doi.org/10.3126/ijls.v6i1.6085.Suche in Google Scholar

15. Rosenzweig, KE, Gomez, JE. Concurrent chemotherapy and radiation therapy for inoperable locally advanced non–small-cell lung cancer. J Clin Oncol 2017;35:6–10. https://doi.org/10.1200/jco.2016.69.9678.Suche in Google Scholar PubMed

16. Prashanth, T, Thirusangu, P, Avin, BV, Ranganatha, VL, Prabhakar, BT, Khanum, SA. Synthesis and evaluation of novel benzophenone-thiazole derivatives as potent VEGF-A inhibitors. Eur J Med Chem 2014;87:274–83. https://doi.org/10.1016/j.ejmech.2014.09.069.Suche in Google Scholar PubMed

17. Somani, RR, Shirodkar, PY. Oxadiazole: a biologically important heterocycle. ChemInform 2011;42. https://doi.org/10.1002/chin.201110251.Suche in Google Scholar

18. Mochona, B, Qi, X, Euynni, S, Sikazwi, D, Mateeva, N, Soliman, KF. Design and evaluation of novel oxadiazole derivatives as potential prostate cancer agents. Bioorg Med Chem Lett 2016;26:2847–51. https://doi.org/10.1016/j.bmcl.2016.04.058.Suche in Google Scholar PubMed PubMed Central

19. Gu, W, Jin, XY, Li, DD, Wang, SF, Tao, XB, Chen, H. Design, synthesis and in vitro anticancer activity of novel quinoline and oxadiazole derivatives of ursolic acid. Bioorg Med Chem Lett 2017;27:4128–32. https://doi.org/10.1016/j.bmcl.2017.07.033.Suche in Google Scholar PubMed

20. Altıntop, MD, Sever, B, Çiftçi, GA, Turan-Zitouni, G, Kaplancıklı, ZA, Özdemir, A. Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors. Eur J Med Chem 2018;155:905–24. https://doi.org/10.1016/j.ejmech.2018.06.049.Suche in Google Scholar PubMed

21. Çevik, UA, Osmaniye, D, Çavuşoğlu, BK, Sağlik, BN, Levent, S, Ilgin, S, et al.. Synthesis of novel benzimidazole–oxadiazole derivatives as potent anticancer activity. Med Chem Res 2019;28:2252–61.10.1007/s00044-019-02451-0Suche in Google Scholar

22. Hamdy, R, Elseginy, SA, Ziedan, NI, El-Sadek, M, Lashin, E, Jones, AT, et al.. Design, synthesis and evaluation of new bioactive oxadiazole derivatives as anticancer agents targeting bcl-2. Int J Mol Sci 2020;21:8980. https://doi.org/10.3390/ijms21238980.Suche in Google Scholar PubMed PubMed Central

23. Chhabria, MT, Patel, S, Modi, P, Brahmkshatriya, S, Thiazole, P. A review on chemistry, synthesis and therapeutic importance of its derivatives. Curr Top Med Chem 2016;16:2841–62. https://doi.org/10.2174/1568026616666160506130731.Suche in Google Scholar PubMed

24. Chhabria, MT, Patel, S, Modi, P, Brahmkshatriya, PS. Thiazole: a review on chemistry, synthesis and therapeutic importance of its derivatives. Curr Top Med Chem 2016;16:2841–62. https://doi.org/10.2174/1568026616666160506130731.Suche in Google Scholar

25. Jain, S, Pattnaik, S, Pathak, K, Kumar, S, Pathak, D, Jain, S, et al.. Anticancer potential of thiazole derivatives: a retrospective review. Mini Rev Med Chem 2018;18:640–55. https://doi.org/10.2174/1389557517666171123211321.Suche in Google Scholar PubMed

26. Sharma, D, Bansal, KK, Sharma, A, Pathak, M, Sharma, PC. A brief literature and review of patents on thiazole related derivatives. Curr Bioact Compd 2019;15:304–15. https://doi.org/10.2174/1573407214666180827094725.Suche in Google Scholar

27. Qureshi, A, Pradhan, A. Short review on thiazole derivative. J Drug Deliv Therapeut 2019;9:842–7.Suche in Google Scholar

28. Alanine, A, Flohr, A, Miller, AK, Norcross, RD, Riemer, C. Benzothiazole derivatives. Geneva: International Search report; 2005.Suche in Google Scholar

29. Harnett, JJ, Roubert, V, Dolo, C, Charnet, C, Spinnewyn, B, Cornet, S, et al.. Phenolic thiazoles as novel orally-active neuroprotective agents. Bioorg Med Chem Lett 2004;14:157–60. https://doi.org/10.1016/j.bmcl.2003.09.077.Suche in Google Scholar PubMed

30. Li, Y, Wu, KJ, Yu, SJ, Tamargo, IA, Wang, Y, Greig, NH. Neurotrophic and neuroprotective effects of oxyntomodulin in neuronal cells and a rat model of stroke. Exp Neurol 2017;288:104–13. https://doi.org/10.1016/j.expneurol.2016.11.010.Suche in Google Scholar PubMed PubMed Central

31. Avila, B, Roth, A, Streets, H, Dwyer, DS, Kurth, MJ. Triazolbenzo [d] thiazoles: efficient synthesis and biological evaluation as neuroprotective agents. Bioorg Med Chem Lett 2012;22:5976–8. https://doi.org/10.1016/j.bmcl.2012.07.022.Suche in Google Scholar PubMed PubMed Central

32. Satoh, A, Nagatomi, Y, Hirata, Y, Ito, S, Suzuki, G, Kimura, T, et al.. Discovery and in vitro and in vivo profiles of 4-fluoro-N-[4-[6-(isopropylamino) pyrimidin-4-yl]-1, 3-thiazol-2-yl]-N-methylbenzamide as novel class of an orally active metabotropic glutamate receptor 1 (mGluR1) antagonist. Bioorg Med Chem Lett 2009;19:5464–8. https://doi.org/10.1016/j.bmcl.2009.07.097.Suche in Google Scholar PubMed

33. Hong, SP, Liu, KG, Ma, G, Sabio, M, Uberti, MA, Bacolod, MD, et al.. Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J Med Chem 2011;54:5070–81. https://doi.org/10.1021/jm200290z.Suche in Google Scholar PubMed

34. Lee, YS, Kim, H, Kim, YH, Roh, EJ, Han, H, Shin, KJ. Synthesis and structure–activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer’s disease. Bioorg Med Chem Lett 2012;22:7555–61. https://doi.org/10.1016/j.bmcl.2012.10.022.Suche in Google Scholar PubMed

35. Andreani, A, Burnelli, S, Granaiola, M, Guardigli, M, Leoni, A, Locatelli, A, et al.. Chemiluminescent high-throughput microassay applied to imidazo [2, 1-b] thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors. Eur J Med Chem 2008;43:657–61. https://doi.org/10.1016/j.ejmech.2007.04.018.Suche in Google Scholar PubMed

36. Lagoja, I, Pannecouque, C, Griffioen, G, Wera, S, Rojasdelaparra, VM, Van Aerschot, A. Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer’s disease. Eur J Pharmaceut Sci 2011;43:386–92. https://doi.org/10.1016/j.ejps.2011.05.014.Suche in Google Scholar PubMed

37. Shiradkar, MR, Akula, KC, Dasari, V, Baru, V, Chiningiri, B, Gandhi, S, et al.. Clubbed thiazoles by MAOS: a novel approach to cyclin-dependent kinase 5/p25 inhibitors as a potential treatment for Alzheimer’s disease. Bioorg Med Chem 2007;15:2601–10. https://doi.org/10.1016/j.bmc.2007.01.043.Suche in Google Scholar PubMed

38. Jimonet, P, Audiau, F, Barreau, M, Blanchard, JC, Boireau, A, Bour, Y, et al.. Riluzole series. Synthesis and in vivo “antiglutamate” activity of 6-substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines. J Med Chem 1999;42:2828–43. https://doi.org/10.1021/jm980202u.Suche in Google Scholar PubMed

39. Andurkar, SV, Béguin, C, Stables, JP, Kohn, H. Synthesis and structural studies of aza analogues of functionalized amino acids: new anticonvulsant agents. J Med Chem 2001;44:1475–8. https://doi.org/10.1021/jm000517l.Suche in Google Scholar PubMed

40. Collins, I, Moyes, C, Davey, WB, Rowley, M, Bromidge, FA, Quirk, K, et al.. 3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional selectivity for α2/α3-subtypes of human GABAA receptor-ion channels. J Med Chem 2002;45:1887–900. https://doi.org/10.1021/jm0110789.Suche in Google Scholar PubMed

41. Mostafa, SM, Aly, AA, Sayed, SM, Raslan, MA, Ahmed, AE, Nafady, A, et al.. New quinoline-2-one/thiazolium bromide derivatives; synthesis, characterization and mechanism of formation. J Mol Struct 2021;1239:130501. https://doi.org/10.1016/j.molstruc.2021.130501.Suche in Google Scholar

42. Altıntop, MD, Sever, B, Akalın Çiftçi, G, Özdemir, A. Design, synthesis, and evaluation of a new series of thiazole-based anticancer agents as potent Akt inhibitors. Molecules 2018;23:1318.10.3390/molecules23061318Suche in Google Scholar PubMed PubMed Central

43. Patel, S, Patle, R, Parameswaran, P, Jain, A, Shard, A. Design, computational studies, synthesis and biological evaluation of thiazole-based molecules as anticancer agents. Eur J Pharmaceut Sci 2019;134:20–30. https://doi.org/10.1016/j.ejps.2019.04.005.Suche in Google Scholar PubMed

44. Abu-Melha, S, Edrees, MM, Salem, HH, Kheder, NA, Gomha, SM, Abdelaziz, MR. Synthesis and biological evaluation of some novel thiazole-based heterocycles as potential anticancer and antimicrobial agents. Molecules 2019;24:539. https://doi.org/10.3390/molecules24030539.Suche in Google Scholar PubMed PubMed Central

45. Shokrollahi, S, Amiri, A, Fadaei-Tirani, F, Schenk-Joß, K. Promising anti-cancer potency of 4, 5, 6, 7-tetrahydrobenzo [d] thiazole-based Schiff-bases. J Mol Liq 2020;300:112262. https://doi.org/10.1016/j.molliq.2019.112262.Suche in Google Scholar

46. Farghaly, TA, Masaret, GS, Muhammad, ZA, Harras, MF. Discovery of thiazole-based-chalcones and 4-heteroarylthiazoles as potent anticancer agents: synthesis, docking study and anticancer activity. Bioorg Chem 2020;98:103761. https://doi.org/10.1016/j.bioorg.2020.103761.Suche in Google Scholar PubMed

47. Kost, AN, Grandberg, II. Progress in pyrazole chemistry. In: Advances in heterocyclic chemistry. England: Academic Press; 1966, 6:347–429 pp.10.1016/S0065-2725(08)60579-6Suche in Google Scholar

48. Ansari, A, Ali, A, Asif, M. Biologically active pyrazole derivatives. New J Chem 2017;41:16–41. https://doi.org/10.1039/c6nj03181a.Suche in Google Scholar

49. Chauhan, A, Sharma, PK, Kaushik, N. Pyrazole: a versatile moiety. Int J Chem Res 2011;3:11–7.Suche in Google Scholar

50. Radi, S, Salhi, S, Radi, A. Synthesis and preliminary biological activity of some new pyrazole derivatives as acyclonucleoside analogues. Lett Drug Des Discov 2010;7:27–30. https://doi.org/10.2174/157018010789869307.Suche in Google Scholar

51. Khan, MF, Alam, MM, Verma, G, Akhtar, W, Akhter, M, Shaquiquzzaman, M. The therapeutic voyage of pyrazole and its analogs: a review. Eur J Med Chem 2016;120:170–201. https://doi.org/10.1016/j.ejmech.2016.04.077.Suche in Google Scholar PubMed

52. Alam, R, Wahi, D, Singh, R, Sinha, D, Tandon, V, Grover, A. Design, synthesis, cytotoxicity, HuTopoIIα inhibitory activity and molecular docking studies of pyrazole derivatives as potential anticancer agents. Bioorg Chem 2016;69:77–90. https://doi.org/10.1016/j.bioorg.2016.10.001.Suche in Google Scholar PubMed

53. Fahmy, HH, Srour, AM, Ismail, MA, Khater, MA, Serrya, RA, El-Manawaty, MA. Design and synthesis of some new tri-substituted pyrazole derivatives as anticancer agents. Res Chem Intermed 2016;42:6881–92. https://doi.org/10.1007/s11164-016-2502-2.Suche in Google Scholar

54. Mukarram, S, Bandgar, BP, Shaikh, RU, Ganapure, SD, Chavan, HV. Synthesis of novel α, α-difluoro-β-hydroxycarbonyl pyrazole derivatives as antioxidant, anti-inflammatory and anticancer agents. Med Chem Res 2017;26:262–73. https://doi.org/10.1007/s00044-016-1744-2.Suche in Google Scholar

55. Wang, FQ, Yang, H, He, B, Jia, YK, Meng, SY, Zhang, C, et al.. A novel domino approach for synthesis of indolyl tetrahydropyrano [4, 3-c] pyrazole derivatives as anticancer agents. Tetrahedron 2016;72:5769–75. https://doi.org/10.1016/j.tet.2016.07.078.Suche in Google Scholar

56. Ran, F, Liu, Y, Zhang, D, Liu, M, Zhao, G. Discovery of novel pyrazole derivatives as potential anticancer agents in MCL. Bioorg Med Chem Lett 2019;29:1060–4. https://doi.org/10.1016/j.bmcl.2019.03.005.Suche in Google Scholar PubMed

57. Sayed, AR, Gomha, SM, Abdelrazek, FM, Farghaly, MS, Hassan, SA, Metz, P. Design, efficient synthesis and molecular docking of some novel thiazolyl-pyrazole derivatives as anticancer agents. BMC Chem 2019;13:1–13. https://doi.org/10.1186/s13065-019-0632-5.Suche in Google Scholar PubMed PubMed Central

58. Thomas, R, Mary, YS, Resmi, KS, Narayana, B, Sarojini, BK, Vijayakumar, G, et al.. Two neoteric pyrazole compounds as potential anti-cancer agents: synthesis, electronic structure, physico-chemical properties and docking analysis. J Mol Struct 2019;1181:455–66. https://doi.org/10.1016/j.molstruc.2019.01.003.Suche in Google Scholar

59. Sathish Kumar, S, Kavitha, HP. Synthesis and biological applications of triazole derivatives–a review. Mini-Reviews Org Chem 2013;10:40–65. https://doi.org/10.2174/1570193x11310010004.Suche in Google Scholar

60. MALANI, AH, Makwana, AH, Makwana, HR. A brief review article: various synthesis and therapeutic importance of 1, 2, 4-triazole and its derivatives. Moroc J Chem 2017;5:5–1.Suche in Google Scholar

61. Shneine, JK, Alaraji, YH. Chemistry of 1, 2, 4-triazole: a review article. Spectroscopy 2016;9:9c.Suche in Google Scholar

62. Saini, MS, Dwivedi, J. Synthesis and biological significances of 1, 2, 4-triazole and its derivatives: a review. Int J Pharmaceut Sci Res 2013;4:2866.10.1002/chin.201424265Suche in Google Scholar

63. Zhou, CH, Wang, Y. Recent researches in triazole compounds as medicinal drugs. Curr Med Chem 2012;19:239–80. https://doi.org/10.2174/092986712803414213.Suche in Google Scholar PubMed

64. Kharb, R, Sharma, PC, Yar, MS. Pharmacological significance of triazole scaffold. J Enzym Inhib Med Chem 2011;26:1–21. https://doi.org/10.3109/14756360903524304.Suche in Google Scholar PubMed

65. Zhang, S, Xu, Z, Gao, C, Ren, QC, Chang, L, Lv, ZS, et al.. Triazole derivatives and their anti-tubercular activity. Eur J Med Chem 2017;138:501–13. https://doi.org/10.1016/j.ejmech.2017.06.051.Suche in Google Scholar PubMed

66. Seck, I, Nguemo, F. Triazole, imidazole, and thiazole-based compounds as potential agents against coronavirus. Res Chem 2021;3:100132. https://doi.org/10.1016/j.rechem.2021.100132.Suche in Google Scholar PubMed PubMed Central

67. Gregorić, T, Sedić, M, Grbčić, P, Paravić, AT, Pavelić, SK, Cetina, M, et al.. Novel pyrimidine-2, 4-dione–1, 2, 3-triazole and furo [2, 3-d] pyrimidine-2-one–1, 2, 3-triazole hybrids as potential anti-cancer agents: synthesis, computational and X-ray analysis and biological evaluation. Eur J Med Chem 2017;125:1247–67. https://doi.org/10.1016/j.ejmech.2016.11.028.Suche in Google Scholar PubMed

68. Singh, H, Singh, JV, Gupta, MK, Saxena, AK, Sharma, S, Nepali, K, et al.. Triazole tethered isatin-coumarin based molecular hybrids as novel antitubulin agents: design, synthesis, biological investigation and docking studies. Bioorg Med Chem Lett 2017;27:3974–9. https://doi.org/10.1016/j.bmcl.2017.07.069.Suche in Google Scholar PubMed

69. Abd-Rabou, AA, Abdel-Wahab, BF, Bekheit, MS. Synthesis, molecular docking, and evaluation of novel bivalent pyrazolinyl-1, 2, 3-triazoles as potential VEGFR TK inhibitors and anti-cancer agents. Chem Pap 2018;72:2225–37. https://doi.org/10.1007/s11696-018-0451-5.Suche in Google Scholar

70. Chekir, S, Debbabi, M, Regazzetti, A, Dargère, D, Laprévote, O, Jannet, HB, et al.. Design, synthesis and biological evaluation of novel 1, 2, 3-triazole linked coumarinopyrazole conjugates as potent anticholinesterase, anti-5-lipoxygenase, anti-tyrosinase and anti-cancer agents. Bioorg Chem 2018;80:189–94. https://doi.org/10.1016/j.bioorg.2018.06.005.Suche in Google Scholar PubMed

71. Zhao, JW, Wu, ZH, Guo, JW, Huang, MJ, You, YZ, Liu, HM, et al.. Synthesis and anti-gastric cancer activity evaluation of novel triazole nucleobase analogues containing steroidal/coumarin/quinoline moieties. Eur J Med Chem 2019;181:111520. https://doi.org/10.1016/j.ejmech.2019.07.023.Suche in Google Scholar PubMed

72. Naaz, F, Ahmad, F, Lone, BA, Pokharel, YR, Fuloria, NK, Fuloria, S, et al.. Design and synthesis of newer 1, 3, 4-oxadiazole and 1, 2, 4-triazole based Topsentin analogues as anti-proliferative agent targeting tubulin. Bioorg Chem 2020;95:103519. https://doi.org/10.1016/j.bioorg.2019.103519.Suche in Google Scholar PubMed

Received: 2021-10-07
Accepted: 2021-11-24
Published Online: 2022-01-19

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
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  4. Metal nanoparticles and its application on phenolic and heavy metal pollutants
  5. The story of nitrogen
  6. Recent development of imidazole derivatives as potential anticancer agents
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https://doi.org/10.1515/psr-2021-0217
Schlagwörter für diesen Artikel
anti-cancer; heterocycles; oxazole; pyrazole; thiazole; triazole and structural activity relationships

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Recent endeavors in microbial remediation of micro- and nanoplastics
  4. Metal nanoparticles and its application on phenolic and heavy metal pollutants
  5. The story of nitrogen
  6. Recent development of imidazole derivatives as potential anticancer agents
  7. Indole based prostate cancer agents
  8. Lawsone (2-hydroxy-1,4-naphthaquinone) derived anticancer agents
  9. Small modular nuclear reactors are mostly bad policy
  10. A holistic environmental investigation of complementary energy in Alberta
  11. Green synthesis of various saturated S-heterocyclic scaffolds: an update
  12. Recent advances of heterocycle based anticancer hybrids
  13. Molecular docking and MD: mimicking the real biological process
  14. Synthesis of quinazolinone and quinazoline derivatives using green chemistry approach
  15. Nuclear fusion: the promise of endless energy
  16. Finance for Green Chemistry through Currency Mix
  17. Synthesis of bioactive scaffolds catalyzed by agro-waste-based solvent medium
  18. Recent developments in the green synthesis of biologically relevant cinnolines and phthalazines
  19. Detection of Rapid Eye Movement Behaviour Sleep Disorder using Time and Frequency Analysis of EEG Signal Applied on C4-A1 Channels
  20. Recent developments in C–C bond formation catalyzed by solid supported palladium: a greener perspective
  21. Visible-light-mediated metal-free C–Si bond formation reactions
  22. An overview of quinoxaline synthesis by green methods: recent reports
  23. Naturally occurring, natural product inspired and synthetic heterocyclic anti-cancer drugs
  24. Synthesis of bioactive natural products and their analogs at room temperature – an update
  25. One-pot multi-component synthesis of diverse bioactive heterocyclic scaffolds involving 6-aminouracil or its N-methyl derivatives as a versatile reagent
  26. Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development
  27. Triazine based chemical entities for anticancer activity
  28. Modification of kaolinite/muscovite clay for the removal of Pb(II) ions from aqueous media
  29. In silico design of ACE2 mutants for competitive binding of SARS-CoV-2 receptor binding domain with hACE2
  30. Computational study of Cu n AgAu (n = 1–4) clusters invoking DFT based descriptors
  31. Development of an online assessment system to evaluate knowledge on chemical safety and security
  32. Developing a questionnaire for diabetes mellitus type 2 risk effects and precondition factors – multivariate statistical paths
  33. Antioxidant and antibacterial activities of two xanthones derivatives isolated from the leaves extract of Anthocleista schweinfurthii Gilg (Loganiaceae)
  34. The stability increase of α-amylase enzyme from Aspergillus fumigatus using dimethyladipimidate
  35. Sustainability of ameliorative potentials of urea spiked poultry manure biochar types in simulated sodic soils
  36. Cytotoxicity test and antibacterial assay on the compound produced by the isolation and modification of artonin E from Artocarpus kemando Miq.
  37. Effects of alum, soda ash, and carbon dioxide on 40–50 year old concrete wastewater tanks
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Heruntergeladen am 8.11.2025 von https://www.degruyterbrill.com/document/doi/10.1515/psr-2021-0217/pdf
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