Antioxidant and antibacterial activities of two xanthones derivatives isolated from the leaves extract of Anthocleista schweinfurthii Gilg (Loganiaceae)
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Francine Tsopjio Nkouam
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Epse Abdourahman Fadimatou
Abstract
Phytochemical investigations on the dechlorophyllated extract of Anthocleista schweinfurthii Gilg (Loganiaceae) leaves have enabled the isolation of two xanthones derivatives: 1,8-dihydroxy-2,6-dimethoxyxanthone (1) and 1-hydroxy-3,7,8-trimethoxyxanthone (2) known, respectively, as swertiaperenin (1) and decussatin (2), but isolated here for the first time from this plant. The structures of these compounds were investigated by rigorous analysis of their one- and two-dimensional NMR spectral data. Compounds (1) and (2) were evaluated for their antioxidant activities using the 1,1-diphenyl-2-picrylhydrazyl method (DPPH°); the reducing power of iron III (FRAP) and antibacterial activity by the solid diffusion method on three bacteria strains (Escherichia coli, Staphylococcus aureus, and Bacillus cereus). The results obtained show that the two compounds have good antioxidant and antibacterial activities. Obviously, swertiaperenin and decussatin are among the active secondary’s metabolites responsible for the biological activity of A. schweinfurthii Gild recognized by the Cameroonian populations.
Funding source: International Foundation for Science (IFS) and the Organization for the Prohibition of Chemical Weapons (OPCW)
Award Identifier / Grant number: No. F/5551-1
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Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: This research work was supported financially by the International Foundation for Science (IFS) and the Organization for the Prohibition of Chemical Weapons (OPCW) through grant No. F/5551-1.
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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Articles in the same Issue
- Frontmatter
- Reviews
- Recent endeavors in microbial remediation of micro- and nanoplastics
- Metal nanoparticles and its application on phenolic and heavy metal pollutants
- The story of nitrogen
- Recent development of imidazole derivatives as potential anticancer agents
- Indole based prostate cancer agents
- Lawsone (2-hydroxy-1,4-naphthaquinone) derived anticancer agents
- Small modular nuclear reactors are mostly bad policy
- A holistic environmental investigation of complementary energy in Alberta
- Green synthesis of various saturated S-heterocyclic scaffolds: an update
- Recent advances of heterocycle based anticancer hybrids
- Molecular docking and MD: mimicking the real biological process
- Synthesis of quinazolinone and quinazoline derivatives using green chemistry approach
- Nuclear fusion: the promise of endless energy
- Finance for Green Chemistry through Currency Mix
- Synthesis of bioactive scaffolds catalyzed by agro-waste-based solvent medium
- Recent developments in the green synthesis of biologically relevant cinnolines and phthalazines
- Detection of Rapid Eye Movement Behaviour Sleep Disorder using Time and Frequency Analysis of EEG Signal Applied on C4-A1 Channels
- Recent developments in C–C bond formation catalyzed by solid supported palladium: a greener perspective
- Visible-light-mediated metal-free C–Si bond formation reactions
- An overview of quinoxaline synthesis by green methods: recent reports
- Naturally occurring, natural product inspired and synthetic heterocyclic anti-cancer drugs
- Synthesis of bioactive natural products and their analogs at room temperature – an update
- One-pot multi-component synthesis of diverse bioactive heterocyclic scaffolds involving 6-aminouracil or its N-methyl derivatives as a versatile reagent
- Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development
- Triazine based chemical entities for anticancer activity
- Modification of kaolinite/muscovite clay for the removal of Pb(II) ions from aqueous media
- In silico design of ACE2 mutants for competitive binding of SARS-CoV-2 receptor binding domain with hACE2
- Computational study of Cu n AgAu (n = 1–4) clusters invoking DFT based descriptors
- Development of an online assessment system to evaluate knowledge on chemical safety and security
- Developing a questionnaire for diabetes mellitus type 2 risk effects and precondition factors – multivariate statistical paths
- Antioxidant and antibacterial activities of two xanthones derivatives isolated from the leaves extract of Anthocleista schweinfurthii Gilg (Loganiaceae)
- The stability increase of α-amylase enzyme from Aspergillus fumigatus using dimethyladipimidate
- Sustainability of ameliorative potentials of urea spiked poultry manure biochar types in simulated sodic soils
- Cytotoxicity test and antibacterial assay on the compound produced by the isolation and modification of artonin E from Artocarpus kemando Miq.
- Effects of alum, soda ash, and carbon dioxide on 40–50 year old concrete wastewater tanks
