Home Triazine based chemical entities for anticancer activity
Article
Licensed
Unlicensed Requires Authentication

Triazine based chemical entities for anticancer activity

  • Jagadees Kumar Gangasani , Siwaswarup Yarasi , Vegi Ganga Modi Naidu and Jayathirtha Rao Vaidya EMAIL logo
Published/Copyright: March 30, 2022
Become an author with De Gruyter Brill
Submit Manuscript Author Information
Physical Sciences Reviews
From the journal Physical Sciences Reviews Volume 8 Issue 10

Abstract

Triazine is a six-membered aromatic nitrogen heterocyclic moiety that was extensively investigated because of its biological properties and, in particular anticancer potentials. Kinases play a crucial role in cancer cell proliferation and metabolism. Triazine derivatives show anticancer activity by inhibiting the lipid kinases like phosphoinositide 3-kinases, mammalian target of rapamycin, receptor tyrosine kinases, like focal adhesion kinase, cyclin-dependent kinases, Rho-associated protein kinases, p21-activated kinases, carbonic anhydrases, enolase inhibitors, microtubules inhibitors, and histone deacetylases. The present chapter highlights the synthesis of triazine-based derivatives, their characterization, evaluation of anticancer properties, and their journey towards possible medicine for cancer.

Keywords: anticancer activity; kinase inhibitors; several kinases; therapeutic value; triazine synthesis
Corresponding author: Jayathirtha Rao Vaidya, Fluoro Agro Chemicals Department and AcSIR-Ghaziabad, CSIR-Indian Institute of Chemical Technology, Uppal Road Tarnaka, Hyderabad, 500007, Telangana, India, E-mail:

Acknowledgement

VJR thank CSIR for Emeritus Scientist Honor.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

References

1. Mehmood, Y, Anwa, F, Saleem, U, Hira, S, Ahmad, B, Bashir, M, et al.. The anti-cancer potential of 2, 4, 6 tris-methyphenylamino1, 3, 5-triazine compound against mammary glands cancer: via down-regulating the hormonal, inflammatory mediators, and oxidative stress. Life Sci 2021;285:119994. https://doi.org/10.1016/j.lfs.2021.119994.Search in Google Scholar PubMed

2. Makhlouf, AA, Maklad, YA. Synthesis and analgesic-anti-inflammatory activities of some 1,2,4-triazine derivatives. Arzneimittelforschung 2004;54:42–9. https://doi.org/10.1055/s-0031-1296935.Search in Google Scholar PubMed

3. Al-Zaydi, KM, Khalil, HH, El-Faham, A, Khattab, SN. Synthesis, characterization and evaluation of 1,3,5-triazine aminobenzoic acid derivatives for their antimicrobial activity. Chem Cent J 2017;11:39. https://doi.org/10.1186/s13065-017-0267-3.Search in Google Scholar PubMed PubMed Central

4. Mibu, N, Yokomizo, K, Sano, M, Kawaguchi, Y, Morimoto, K, Shimomura, S, et al.. Preparation and antiviral activity of some new C3- and CS-symmetrical tri-substituted triazine derivatives having benzylamine substituents. Chem Pharm Bull 2018;66:830–8. https://doi.org/10.1248/cpb.c18-00274.Search in Google Scholar PubMed

5. Viswanatha, GL, Priyadarshini, BJ, Krishnadas, N, Janardhanan, S, Rangappa, S, Hanumanthappa, S. Synthesis and antihistaminic activity of 3H-benzo [4,5] thieno [2,3-d][1,2,3] triazin-4-ones. Saudi Pharmaceut J 2012;20:45–52. https://doi.org/10.1016/j.jsps.2011.05.005.Search in Google Scholar PubMed PubMed Central

6. Pathak, P, Shukla, PK, Kumar, V, Kumar, A, Verma, A. Quinazoline clubbed 1,3,5-triazine derivatives as VEGFR2 kinase inhibitors: design, synthesis, docking, in vitro cytotoxicity and in ovo antiangiogenic activity. Inflammopharmacology 2018;26:1441–53. https://doi.org/10.1007/s10787-018-0471-3.Search in Google Scholar PubMed

7. Cirrincione, G, Almerico, AM, Barraja, P, Diana, P, Lauria, A, Passannanti, A, et al.. Derivatives of the new ring system indolo[1,2-c]benzo[1,2,3]triazine with potent antitumor and antimicrobial activity. J Med Chem 1999;42:2561–8. https://doi.org/10.1021/jm9806087.Search in Google Scholar PubMed

8. Migawa, MT, Drach, JC, Townsend, LB. Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-methyl-1-(beta-D-ribofuranosyl)- and 3-amino-5-methyl-1-(2-deoxy-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,7,8-hexaazaacenaphthylene as analogues of triciribine. J Med Chem 2005;48:3840–51. https://doi.org/10.1021/jm0402014.Search in Google Scholar PubMed

9. Lauria, A, Alfio, A, Bonsignore, R, Gentile, C, Martorana, A, Gennaro, G, et al.. New benzothieno[3,2-d]-1,2,3-triazines with antiproliferative activity: synthesis, spectroscopic studies, and biological activity. Bioorg Med Chem Lett 2014;24:3291–7. https://doi.org/10.1016/j.bmcl.2014.06.007.Search in Google Scholar PubMed

10. Elrayess, R, Abdel Aziz, YM, Elgawish, MS, Elewa, M, Elshihawy, HA, Said, MM. Pharmacophore modeling, 3D-QSAR, synthesis, and anti-lung cancer evaluation of novel thieno[2,3-d][1,2,3]triazines targeting EGFR. Arch Pharm 2020;353: e1900108. https://doi.org/10.1002/ardp.201900108.Search in Google Scholar PubMed

11. Nasr, T, Bondock, S, Youns, M, Fayad, W, Zaghary, W. Synthesis, antitumor evaluation and microarray study of some new pyrazolo[3,4-d][1,2,3]triazine derivatives. Eur J Med Chem 2017;141:603–14. https://doi.org/10.1016/j.ejmech.2017.10.016.Search in Google Scholar PubMed

12. Lv, JL, Wang, R, Liu, D, Guo, G, Jing, YK, Zhao, LX. Design, synthesis, and antitumor activities of some novel substituted 1,2,3-benzotriazines. Molecules 2008;13:1427–40. https://doi.org/10.3390/molecules13061427.Search in Google Scholar PubMed PubMed Central

13. Zhao, XW, Liu, D, Luan, SL, Hu, GD, Lv, JL, Jing, YK, et al.. Synthesis and biological evaluation of substituted 1,2,3-benzotriazines and pyrido[3,2-d]-1,2,3-triazines as inhibitors of vascular endothelial growth factor receptor-2. Bioorg Med Chem 2013;21:7807–15. https://doi.org/10.1016/j.bmc.2013.10.009.Search in Google Scholar PubMed

14. Fan, YB, Li, K, Huang, M, Cao, Y, Li, Y, Jin, SY, et al.. Design and synthesis of substituted pyrido[3,2-d]-1,2,3-triazines as potential Pim-1 inhibitors. Bioorg Med Chem Lett 2016;26:1224–8. https://doi.org/10.1016/j.bmcl.2016.01.032.Search in Google Scholar PubMed

15. el-Gendy, Z, Morsy, JM, Allimony, HA, Ali, WR, Abdel-Rahman, RM. Synthesis of heterobicyclic nitrogen systems bearing the 1,2,4-triazine moiety as anti-HIV and anticancer drugs, part III. Pharmazie 2001;56:376–83.10.1002/chin.200132165Search in Google Scholar

16. Schmitz, WD, Brenner, AB, Bronson, JJ, Ditta, JL, Griffin, CR, Li, YW, et al.. 5-arylamino-1,2,4-triazin-6(1H)-one CRF1 receptor antagonists. Bioorg Med Chem Lett 2010;20:3579–83. https://doi.org/10.1016/j.bmcl.2010.04.121.Search in Google Scholar PubMed

17. Sztanke, K, Sidor-Wójtowicz, A, Truchlińska, J, Pasternak, K, Sztanke, M. Antimicrobial screening of certain fused 1,2,4-triazine derivatives. Ann Univ Mariae Curie-Sklodowska Med 2004;59:342–5.Search in Google Scholar

18. Mullick, P, Khan, SA, Begum, T, Verma, S, Kaushik, D, Alam, O. Synthesis of 1,2,4-triazine derivatives as potential anti-anxiety and anti-inflammatory agents. Acta Pol Pharm 2009;66:379–85.Search in Google Scholar

19. Gucký, T, Frysová, I, Slouka, J, Hajdúch, M, Dzubá, P. Cyclocondensation reaction of heterocyclic carbonyl compounds. Part XIII: synthesis and cytotoxic activity of some 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines. Eur J Med Chem 2009;44:891–900. https://doi.org/10.1016/j.ejmech.2008.05.026.Search in Google Scholar PubMed

20. Mojzych, M, Šubertová, V, Bielawska, A, Bielawski, K, Bazgier, V, Berka, K, et al.. Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines. Eur J Med Chem 2014;78:217–24. https://doi.org/10.1016/j.ejmech.2014.03.054.Search in Google Scholar PubMed

21. Mojzych, M, Bielawska, A, Bielawski, K, Ceruso, M, Supuran, CT. Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity. Bioorg Med Chem 2014;22:2643–7. https://doi.org/10.1016/j.bmc.2014.03.029.Search in Google Scholar PubMed

22. Mojzych, M, Karczmarzyk, Z, Wysocki, W, Ceruso, M, Supuran, CT, Kryštof, V, et al.. New approaches to the synthesis of sildenafil analogues and their enzyme inhibitory activity. Bioorg Med Chem 2015;23:1421–9. https://doi.org/10.1016/j.bmc.2015.02.026.Search in Google Scholar PubMed

23. Mojzych, M, Ceruso, M, Bielawska, A, Bielawski, K, Fornal, E, Supuran, CT. New pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors. Bioorg Med Chem 2015;23:3674–80. https://doi.org/10.1016/j.bmc.2015.04.011.Search in Google Scholar PubMed

24. Sweeney, M, Coyle, R, Kavanagh, P, Berezin, AA, Lo Re, D, Zissimou, GA, et al.. Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: very strong correlation to pleurotin and thioredoxin reductase inhibition. Bioorg Med Chem 2016;24:3565–70. https://doi.org/10.1016/j.bmc.2016.05.066.Search in Google Scholar PubMed

25. Foster, BJ, Harding, BJ, Leyland-Jones, B, Ho, D. Hexamethylmelamine: a critical review of an active drug. Cancer Treat Rev 1986;13:197–217. https://doi.org/10.1016/0305-7372(86)90006-x.Search in Google Scholar PubMed

26. Ono, M, Kawahara, N, Goto, D, Wakabayashi, Y, Ushiro, S, Yoshida, S, et al.. Inhibition of tumor growth and neovascularization by an anti-gastric ulcer agent, irsogladine. Cancer Res 1996;56:1512–6.Search in Google Scholar

27. Moon, HS, Jacobson, EM, Khersonsky, SM, Luzung, MR, Walsh, DP, Xiong, W, et al.. A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening. J Am Chem Soc 2002;124:11608–9. https://doi.org/10.1021/ja026720i.Search in Google Scholar PubMed

28. Leftheris, K, Ahmed, G, Chan, R, Dyckman, AJ, Hussain, Z, Ho, K, et al.. The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase. J Med Chem 2004;47:6283–91. https://doi.org/10.1021/jm049521d.Search in Google Scholar PubMed

29. Kuo, GH, Deangelis, A, Emanuel, S, Wang, A, Zhang, Y, Connolly, PJ, et al.. Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors. J Med Chem 2005;48:4535–46. https://doi.org/10.1021/jm040214h.Search in Google Scholar PubMed

30. Baindur, N, Chadha, N, Brandt, BM, Asgari, D, Patch, RJ, Schalk-Hihi, C, et al.. 2-Hydroxy-4,6-diamino-[1,3,5]triazines: a novel class of VEGF-R2 (KDR) tyrosine kinase inhibitors. J Med Chem 2005;48:1717–20. https://doi.org/10.1021/jm049372z.Search in Google Scholar PubMed

31. Kumar, R, Gupta, L, Pal, P, Khan, S, Singh, N, Katiyar, SB, et al.. Synthesis and cytotoxicity evaluation of (tetrahydro-β-carboline)-1, 3, 5-triazine hybrids as anticancer agents. Eur J Med Chem 2010;45:2265–76. https://doi.org/10.1016/j.ejmech.2010.02.001.Search in Google Scholar PubMed

32. Moreno, LM, Quiroga, J, Abonia, R, Ramírez-Prada, J, Insuasty, BJM. Synthesis of new 1, 3, 5-triazine-based 2-pyrazolines as potential anticancer agents. Molecules 2018;23:1956–76. https://doi.org/10.3390/molecules23081956.Search in Google Scholar PubMed PubMed Central

33. Rania, M, Mohamed, A, Hassan, M. Design, synthesis and molecular modeling of new 1, 3, 5-triazine derivatives as anticancer agents. Der Pharma Chem 2019;11:7–14.Search in Google Scholar

34. Kumar, GJ, Kumar, SN, Thummuri, D, Adari, LBS, Naidu, VGM, Srinivas, K, et al.. Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents. Med Chem Res 2015;24:3991–4001. https://doi.org/10.1007/s00044-015-1430-9.Search in Google Scholar

35. Jagadeesh Kumar, G, Sriramkumar Bomma, H, Srihari, E, Shrivastava, S, Naidu, VGM, Srinivas, K, et al.. Synthesis and anticancer activity of some new s-triazine derivatives. Med Chem Res 2013;22:5973–81. https://doi.org/10.1007/s00044-013-0584-6.Search in Google Scholar

36. Patel, RV, Kumari, P, Rajani, DP, Chikhalia, KHJE. Synthesis and studies of novel 2-(4-cyano-3-trifluoromethylphenyl amino)-4-(quinoline-4-yloxy)-6-(piperazinyl/piperidinyl)-s-triazines as potential antimicrobial, antimycobacterial and anticancer agents. Eur J Med Chem 2011;46:4354–65. https://doi.org/10.1016/j.ejmech.2011.07.006.Search in Google Scholar PubMed

37. Xiao, S-C, Liu, C-Z, Liu, W-K, Xie, W-Z, Lin, W-Y, Jiang, G-F, et al.. Phthalocyanines, Selective synthesis and biological activity of triazine-porphyrins as potential anti-cancer agents. J Porphyr Phthalocyanines 2010;14:123–7. https://doi.org/10.1142/s1088424610001805.Search in Google Scholar

38. Shanmugam, M, Narayanan, K, Prasad, KH, Karthikeyan, D, Chandrasekaran, L, Atchudan, R, et al.. Synthesis, characterization, and antiproliferative and apoptosis inducing effects of novel s-triazine derivatives. New J Chem 2018;42:1698–714. https://doi.org/10.1039/c7nj03348f.Search in Google Scholar

39. Al Rasheed, H, Dahlous, K, Sharma, A, Sholkamy, E, El-Faham, A, de la Torre, BG, et al.. Barbiturate- and thiobarbituarte-based s-triazine hydrazone derivatives with promising antiproliferative activities. ACS Omega 2020;5:15805–11. https://doi.org/10.1021/acsomega.0c00468.Search in Google Scholar PubMed PubMed Central

40. Srivastava, JK, Pillai, GG, Bhat, HR, Verma, A, Singh, UP. Design and discovery of novel monastrol-1, 3, 5-triazines as potent anti-breast cancer agent via attenuating epidermal growth factor receptor tyrosine kinase. Sci Rep 2017;7:1–18. https://doi.org/10.1038/s41598-017-05934-5.Search in Google Scholar PubMed PubMed Central

41. Bhat, HR, Masih, A, Shakya, A, Ghosh, SK, Singh, UP. Design, synthesis, anticancer, antibacterial, and antifungal evaluation of 4‐aminoquinoline‐1, 3, 5‐triazine derivatives. J Heterocycl Chem 2020;57:390–9. https://doi.org/10.1002/jhet.3791.Search in Google Scholar

42. Farooq, M, Sharma, A, Almarhoon, Z, Al-Dhfyan, A, El-Faham, A, Taha, NA, et al.. Design and synthesis of mono-and di-pyrazolyl-s-triazine derivatives, their anticancer profile in human cancer cell lines, and in vivo toxicity in zebrafish embryos. Bioorg Chem 2019;87:457–64. https://doi.org/10.1016/j.bioorg.2019.03.063.Search in Google Scholar PubMed

43. Junaid, A, Lim, FPL, Tiekink, ER, Dolzhenko, AVJRA. Design, synthesis, and biological evaluation of new 6, N 2-diaryl-1, 3, 5-triazine-2, 4-diamines as anticancer agents selectively targeting triple negative breast cancer cells. RSC Adv 2020;10:25517–28. https://doi.org/10.1039/d0ra04970k.Search in Google Scholar PubMed PubMed Central

44. Junaid, A, Lim, FPL, Chuah, LH, Dolzhenko, AVJRA. 6, N 2-Diaryl-1, 3, 5-triazine-2, 4-diamines: synthesis, antiproliferative activity and 3D-QSAR modeling. RSC Adv 2020;10:12135–44. https://doi.org/10.1039/d0ra00643b.Search in Google Scholar PubMed PubMed Central

45. MMoreno, L, Quiroga, J, Abonia, R, Lauria, A, Martorana, A, Insuasty, H, et al.. Synthesis, biological evaluation, and in silico studies of novel chalcone-and pyrazoline-based 1, 3, 5-triazines as potential anticancer agents. RSC Adv 2020;10:34114–29. https://doi.org/10.1039/d0ra06799g.Search in Google Scholar PubMed PubMed Central

46. Manohar, S, Pepe, A, Gerena, CEV, Zayas, B, Malhotra, SV, Rawat, DSRJA. Anticancer activity of 4-aminoquinoline-triazine based molecular hybrids. RSC Adv 2014;4:7062–67. https://doi.org/10.1039/c3ra45333b.Search in Google Scholar

47. Venkatesan, AM, Dehnhardt, CM, Delos Santos, E, Chen, Z, Dos Santos, O, Ayral-Kaloustian, S, et al.. Bis (morpholino-1, 3, 5-triazine) derivatives: potent adenosine 5′-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor. J Med Chem 2010;53:2636–45. https://doi.org/10.1021/jm901830p.Search in Google Scholar PubMed

48. Zheng, M, Xu, C, Ma, J, Sun, Y, Du, F, Liu, H, et al.. Synthesis and antitumor evaluation of a novel series of triaminotriazine derivatives. Bioorg Med Chem 2007;15:1815–27. https://doi.org/10.1016/j.bmc.2006.11.028.Search in Google Scholar PubMed

Published Online: 2022-03-30

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Recent endeavors in microbial remediation of micro- and nanoplastics
  4. Metal nanoparticles and its application on phenolic and heavy metal pollutants
  5. The story of nitrogen
  6. Recent development of imidazole derivatives as potential anticancer agents
  7. Indole based prostate cancer agents
  8. Lawsone (2-hydroxy-1,4-naphthaquinone) derived anticancer agents
  9. Small modular nuclear reactors are mostly bad policy
  10. A holistic environmental investigation of complementary energy in Alberta
  11. Green synthesis of various saturated S-heterocyclic scaffolds: an update
  12. Recent advances of heterocycle based anticancer hybrids
  13. Molecular docking and MD: mimicking the real biological process
  14. Synthesis of quinazolinone and quinazoline derivatives using green chemistry approach
  15. Nuclear fusion: the promise of endless energy
  16. Finance for Green Chemistry through Currency Mix
  17. Synthesis of bioactive scaffolds catalyzed by agro-waste-based solvent medium
  18. Recent developments in the green synthesis of biologically relevant cinnolines and phthalazines
  19. Detection of Rapid Eye Movement Behaviour Sleep Disorder using Time and Frequency Analysis of EEG Signal Applied on C4-A1 Channels
  20. Recent developments in C–C bond formation catalyzed by solid supported palladium: a greener perspective
  21. Visible-light-mediated metal-free C–Si bond formation reactions
  22. An overview of quinoxaline synthesis by green methods: recent reports
  23. Naturally occurring, natural product inspired and synthetic heterocyclic anti-cancer drugs
  24. Synthesis of bioactive natural products and their analogs at room temperature – an update
  25. One-pot multi-component synthesis of diverse bioactive heterocyclic scaffolds involving 6-aminouracil or its N-methyl derivatives as a versatile reagent
  26. Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development
  27. Triazine based chemical entities for anticancer activity
  28. Modification of kaolinite/muscovite clay for the removal of Pb(II) ions from aqueous media
  29. In silico design of ACE2 mutants for competitive binding of SARS-CoV-2 receptor binding domain with hACE2
  30. Computational study of Cu n AgAu (n = 1–4) clusters invoking DFT based descriptors
  31. Development of an online assessment system to evaluate knowledge on chemical safety and security
  32. Developing a questionnaire for diabetes mellitus type 2 risk effects and precondition factors – multivariate statistical paths
  33. Antioxidant and antibacterial activities of two xanthones derivatives isolated from the leaves extract of Anthocleista schweinfurthii Gilg (Loganiaceae)
  34. The stability increase of α-amylase enzyme from Aspergillus fumigatus using dimethyladipimidate
  35. Sustainability of ameliorative potentials of urea spiked poultry manure biochar types in simulated sodic soils
  36. Cytotoxicity test and antibacterial assay on the compound produced by the isolation and modification of artonin E from Artocarpus kemando Miq.
  37. Effects of alum, soda ash, and carbon dioxide on 40–50 year old concrete wastewater tanks
https://doi.org/10.1515/psr-2022-0005
Keywords for this article
anticancer activity; kinase inhibitors; several kinases; therapeutic value; triazine synthesis

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Recent endeavors in microbial remediation of micro- and nanoplastics
  4. Metal nanoparticles and its application on phenolic and heavy metal pollutants
  5. The story of nitrogen
  6. Recent development of imidazole derivatives as potential anticancer agents
  7. Indole based prostate cancer agents
  8. Lawsone (2-hydroxy-1,4-naphthaquinone) derived anticancer agents
  9. Small modular nuclear reactors are mostly bad policy
  10. A holistic environmental investigation of complementary energy in Alberta
  11. Green synthesis of various saturated S-heterocyclic scaffolds: an update
  12. Recent advances of heterocycle based anticancer hybrids
  13. Molecular docking and MD: mimicking the real biological process
  14. Synthesis of quinazolinone and quinazoline derivatives using green chemistry approach
  15. Nuclear fusion: the promise of endless energy
  16. Finance for Green Chemistry through Currency Mix
  17. Synthesis of bioactive scaffolds catalyzed by agro-waste-based solvent medium
  18. Recent developments in the green synthesis of biologically relevant cinnolines and phthalazines
  19. Detection of Rapid Eye Movement Behaviour Sleep Disorder using Time and Frequency Analysis of EEG Signal Applied on C4-A1 Channels
  20. Recent developments in C–C bond formation catalyzed by solid supported palladium: a greener perspective
  21. Visible-light-mediated metal-free C–Si bond formation reactions
  22. An overview of quinoxaline synthesis by green methods: recent reports
  23. Naturally occurring, natural product inspired and synthetic heterocyclic anti-cancer drugs
  24. Synthesis of bioactive natural products and their analogs at room temperature – an update
  25. One-pot multi-component synthesis of diverse bioactive heterocyclic scaffolds involving 6-aminouracil or its N-methyl derivatives as a versatile reagent
  26. Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development
  27. Triazine based chemical entities for anticancer activity
  28. Modification of kaolinite/muscovite clay for the removal of Pb(II) ions from aqueous media
  29. In silico design of ACE2 mutants for competitive binding of SARS-CoV-2 receptor binding domain with hACE2
  30. Computational study of Cu n AgAu (n = 1–4) clusters invoking DFT based descriptors
  31. Development of an online assessment system to evaluate knowledge on chemical safety and security
  32. Developing a questionnaire for diabetes mellitus type 2 risk effects and precondition factors – multivariate statistical paths
  33. Antioxidant and antibacterial activities of two xanthones derivatives isolated from the leaves extract of Anthocleista schweinfurthii Gilg (Loganiaceae)
  34. The stability increase of α-amylase enzyme from Aspergillus fumigatus using dimethyladipimidate
  35. Sustainability of ameliorative potentials of urea spiked poultry manure biochar types in simulated sodic soils
  36. Cytotoxicity test and antibacterial assay on the compound produced by the isolation and modification of artonin E from Artocarpus kemando Miq.
  37. Effects of alum, soda ash, and carbon dioxide on 40–50 year old concrete wastewater tanks
Sign up now to receive a 20% welcome discount
Institutional Access
How does access work?
Have an idea on how to improve our website?
Please write us.
© 2025 De Gruyter Brill
Downloaded on 11.9.2025 from https://www.degruyterbrill.com/document/doi/10.1515/psr-2022-0005/html
Scroll to top button