Startseite The effects of Cynodon dactylon (Poaceae family) and Dolichos biflorus (Fabaceae family) extracts on decreasing size and excretion of kidney and urinary tract stones: a randomized, double-blind controlled trial
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The effects of Cynodon dactylon (Poaceae family) and Dolichos biflorus (Fabaceae family) extracts on decreasing size and excretion of kidney and urinary tract stones: a randomized, double-blind controlled trial

  • Mohammad Azad Manjiri , Amir Abbas Asadpour , Mahdi Yousefi , Jamshid Jamali ORCID logo , Behrooz Davachi , Mohammad Reza Ahmadpour und Roshanak Salari EMAIL logo
Veröffentlicht/Copyright: 9. August 2022
Journal of Complementary and Integrative Medicine
Aus der Zeitschrift Journal of Complementary and Integrative Medicine Band 20 Heft 1

Abstract

Objectives

Given high and growing prevalence rate of urolithiasis in most societies as well as the problems caused by this issue, it is necessary to apply more cost-effective and safer therapeutic methods, which are accessible for all the individuals worldwide. Therefore, this study aimed to investigate efficacy of herbal medicines named Cynodon dactylon and Dolichos biflorus on solving and excretion of renal and urinary tract stones in patients with urolithiasis.

Methods

This study included 96 patients with urolithiasis who were randomly allocated into three groups. The first group received the extract of D. biflorus seeds (1,600 mg), the second group received extract of C. dactylon rhizome (1,600 mg) and the third group received placebo for 21 days. In this study, we used an hydroalcoholic extract of D. biflorus and C. dactylon prepared by Soxhlet method. For each patient, the size of the stones, the amount of calcium in the urine, the number of stones excreted and their chemical substance type were measured.

Results

In this study, changes were observed at the significance level in the interventions groups of 1 and 2, and the placebo group in the left kidney, so that changes in size of the stone in left kidney as intergroup were significantly different in these three groups (p=0.02). The mean of changes in stone size in left kidney in the group C. dactylon was 3.78 ± 7.1 and in the group D. biflorus, it was 0.27 ± 0.6.

Conclusions

A significant difference in the results of this study show that C. dactylon rhizome and D. biflorus seed extracts are able to decrease the size of the stone and can be effective on kidney stones excretion.

Keywords: Cynodon dactylon ; Dolichos biflorus ; lithagogue; lithotriptic; urolithiasis
Corresponding author: Dr. Roshanak Salari, Associate Professor, Department of Pharmaceutical Sciences in Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, E-mail:

Funding source: Mashhad University of Medical Sciences

  1. Research funding: This study was supported by School of Persian and complementary medicine and Mashhad University of Medical Sciences Research Council. This paper is part of PhD thesis of Mohammad Azad Manjiri (Ph.D student of Persian Medicine). We highly appreciate Deputy Director of Research at Mashhad University of Medical Sciences and the valuable assistance of the colleagues of Imam Reza Hospital in Mashhad and all the patients who referred. The research budget of this study has been paid by Mashhad University of Medical Sciences.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: The authors confirm that there are no conflicts of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The study was approved by the Ethics Committee of Mashhad University of Medical Sciences with IR.MUMS.REC.1397.325 verification code. It was also registered at the Iranian Center for Clinical Trials(IRCT) with IRCT20190410043235N1verification code.

References

1. Wang, W, Fan, J, Huang, G, Li, J, Zhu, X, Tian, Y, et al.. Prevalence of kidney stones in mainland China: a systematic review. Sci Rep 2017;7:1–9. https://doi.org/10.1038/srep41630.Suche in Google Scholar PubMed PubMed Central

2. McAninch, JW, Lue, TF. Smith & Tanagho’s general urology. New York: McGraw-Hill Medical; 2013.Suche in Google Scholar

3. Pearle, MS, Antonelli, JA, Iotan, Y. Campbell-walsh urology, 11th ed. Philadelphia: Elsevier; 2016, 2:1170–200 pp.Suche in Google Scholar

4. Khan, SR. Is oxidative stress, a link between nephrolithiasis and obesity, hypertension, diabetes, chronic kidney disease, metabolic syndrome? Urol Res 2012;40:95–112. https://doi.org/10.1007/s00240-011-0448-9.Suche in Google Scholar PubMed PubMed Central

5. Golshan, A, Hayatdavoudi, P, Mousa, A, Rad, AK, Roshan, NM, Abbasnezhad, A, et al.. Kidney stone formation and antioxidant effects of Cynodon dactylon decoction in male Wistar rats. Avicenna J Phytomedicine 2017;7:180.Suche in Google Scholar

6. Daudon, M, Jungers, P. Stone composition and morphology: a window on etiology. Urolithiasis: Springer; 2012:113–40 pp.10.1007/978-1-4471-4387-1_15Suche in Google Scholar

7. JrEDV. Kidney stone disease say no to stones. New York, NY, New York Dordrecht London: USA Springer Cham Heidelberg; 2015.Suche in Google Scholar

8. Lingeman, JE, Woods, J, Toth, PD, Evan, AP, McAteer, JA. The role of lithotripsy and its side effects. J Urol 1989;141:793–7. https://doi.org/10.1016/s0022-5347(17)41012-3.Suche in Google Scholar PubMed

9. Mousavi-Bahar, SH, Mehrabi, S, Moslemi, MK. Percutaneous nephrolithotomy complications in 671 consecutive patients: a single-center experience. Urol J 2011;8:271–6.Suche in Google Scholar

10. Ahmed, S, Hasan, MM, Mahmood, ZA. Antiurolithiatic plants in different countries and cultures. J Pharmacogn Phytochem 2016;5:102.Suche in Google Scholar

11. Zargari, A. Medicinal plants, 5th ed. Tehran, Iran: Tehran University of Medical Sciences, Tehran University Publications; 1993, 4:748–52 pp.Suche in Google Scholar

12. Ahmed, S, Hasan, MM, Mahmood, ZA. Macrotyloma uniflorum (Lam.) verdc.(Papilionaceae): a review of medicinal uses, phytochemistry and pharmacology. World J Pharm Pharmaceut Sci 2016;5:51–62. https://doi.org/10.7897/2277-4572.0516.Suche in Google Scholar

13. Amz, R. Al-hawi or Kitāb al-Ḥāwī fī al-ṭibb. Beirut: Daralehya -altras al-arabi; 1991:79–314 pp.Suche in Google Scholar

14. Avecina. Al-Qanun fi teb. Beirut: Beirut Research of literature; 2005.Suche in Google Scholar

15. Ashokkumar, K, Selvaraj, K, Muthukrishnan, SD. Cynodon dactylon (L.) Pers.: an updated review of its phytochemistry and pharmacology. J Med Plants Res 2013;7:3477–83.Suche in Google Scholar

16. Savadi, S, Vazifedoost, M, Didar, Z, Nematshahi, MM, Jahed, E. Phytochemical analysis and antimicrobial/antioxidant activity of Cynodon dactylon (L.) Pers. rhizome methanolic extract. J Food Qual 2020;1–10.10.1155/2020/5946541Suche in Google Scholar

17. Saroja, M, Santhi, R, Annapoorani, S. Antioxidant potential of ethyl acetate fraction of Cynodon dactylon against ELA implanted Swiss albino mice. Int J Pharm Biol Sci 2012;3:415–9.Suche in Google Scholar

18. Roy, S, Pawar, S, Chowdhary, A. Evaluation of in vitro cytotoxic and antioxidant activity of Datura metel Linn. and Cynodon dactylon Linn. extracts. Pharmacogn Res 2016;8:123. https://doi.org/10.4103/0974-8490.175610.Suche in Google Scholar PubMed PubMed Central

19. Kowsalya, R, Kaliaperumal, J, Vaishnavi, M, Namasivayam, E. Anticancer activity of Cynodon dactylon L. root extract against diethyl nitrosamine induced hepatic carcinoma. South Asian J Cancer 2015;4:83–7. https://doi.org/10.4103/2278-330X.155691.Suche in Google Scholar PubMed PubMed Central

20. Salahuddin, H, Mansoor, Q, Batool, R, Farooqi, AA, Mahmood, T, Ismail, M. Anticancer activity of Cynodon dactylon and Oxalis corniculata on Hep2 cell line. Cell Mol Biol 2016;62:60–3.Suche in Google Scholar

21. Abdullah, S, GobilikJ, Chong, KP. Preliminary phytochemical study and antimicrobial activity from various extract of Cynodon dactylon (L.) pers.(Bermuda) against selected pathogens. Int J Pharm Pharmaceut Sci 2012;4(Suppl 5):227–30.10.1007/978-1-4614-6208-8_29Suche in Google Scholar

22. Chandel, E, Kumar, B. Antimicrobial activity and phytochemical analysis of Cynodon dactylon: a review. World J Pharm Pharmaceut Sci 2015;4:515–30.Suche in Google Scholar

23. Jarald, E, Joshi, S, Jain, D. Antidiabetic activity of aqueous extract and non polysaccharide fraction of Cynodon dactylon Pers. Mandsaur. 2008;46:660–7.Suche in Google Scholar

24. Atmani, F, Sadki, C, Aziz, M, Mimouni, M, Hacht, B. Cynodon dactylon extract as a preventive and curative agent in experimentally induced nephrolithiasis. Urol Res 2009;37:75–82. https://doi.org/10.1007/s00240-009-0174-8.Suche in Google Scholar PubMed

25. Khajavi Rad, A, Hadjzadeh, MA, Rajaei, Z, Mohammadian, N, Valiollahi, S, Sonei, M. The beneficial effect of cynodon dactylon fractions on ethylene glycol-induced kidney calculi in rats. Urol J 2011;8:179–84.Suche in Google Scholar

26. Biswas, TK, Pandit, S, Chakrabarti, S, Banerjee, S, Poyra, N, Seal, T. Evaluation of Cynodon dactylon for wound healing activity. J Ethnopharmacol 2017;197:128–37. https://doi.org/10.1016/j.jep.2016.07.065.Suche in Google Scholar PubMed

27. Thakare, VM, Chaudhari, R, Patil, V. Wound healing evaluation of some herbal formulations containing Curcuma longa and Cynodon dactylon extract. Int J Phytomed 2011;3:325–32.Suche in Google Scholar

28. Patil, M, Jalalpure, S, Prakash, N, Kokate, C, editors. Antiulcer properties of alcoholic extract of Cynodon dactylon in rats. In: III WOCMAP congress on medicinal and aromatic plants-volume 6. traditional medicine and nutraceuticals, vol 680; 2003.Suche in Google Scholar

29. Abbaszadeh, S, Garjani, A, Nazemiyeh, H, Ayadi, S, Milani, MM, Soraya, H. Hydroalcoholic extract from rhizomes of cynodon dactylon improve hemodynamic and electrocardiogram parameters in myocardial infarction in rats. Pharmaceut Sci 2019;25:198–204. https://doi.org/10.15171/ps.2019.29.Suche in Google Scholar

30. Pashaie, B, Hobbenaghi, R, Malekinejad, H. Anti-atherosclerotic effect of Cynodon dactylon extract on experimentally induced hypercholesterolemia in rats. Vet Res Forum : an Int J 2017;8:185–93.Suche in Google Scholar

31. Soraya, H, Moloudizargari, M, Aghajanshakeri, S, Javaherypour, S, Mokarizadeh, A, Hamedeyazdan, S, et al.. Angiogenic effect of the aqueous extract of Cynodon dactylon on human umbilical vein endothelial cells and granulation tissue in rat. Daru : J Fac Pharm Tehran University of Medical Sciences 2015;23:10. https://doi.org/10.1186/s40199-015-0093-x.Suche in Google Scholar PubMed PubMed Central

32. Garjani, A, Afrooziyan, A, Nazemiyeh, H, Najafi, M, Kharazmkia, A, Maleki-Dizaji, N. Protective effects of hydroalcoholic extract from rhizomes of Cynodon dactylon (L.) Pers. on compensated right heart failure in rats. BMC Compl Alternative Med 2009;9:289. https://doi.org/10.1186/1472-6882-9-28.Suche in Google Scholar PubMed PubMed Central

33. Bijarnia, RK, Kaur, T, Singla, SK, Tandon, C. A novel calcium oxalate crystal growth inhibitory protein from the seeds of Dolichos biflorus (L.). Protein J 2009;28:161–8. https://doi.org/10.1007/s10930-009-9179-y.Suche in Google Scholar PubMed

34. Singh, SK, Rai, PK, Jaiswal, D, Rai, D, Sherma, B, Watal, G. Protective effect of Cynodon dactylon against STZ induced hepatic injury in rats. J Ecophysiol Occup Health 2008;8:195–9.Suche in Google Scholar

35. Peshin, A, Singla, S. Anticalcifying properties of Dolichos biflorus (horse gram) seeds. Indian J Exp Biol 1994;32:889–91.Suche in Google Scholar

36. Garimella, T, Jolly, C, Narayanan, S. In vitro studies on antilithiatic activity of seeds of Dolichos biflorus Linn. and rhizomes of Bergenia ligulata Wall. Phytother Res 2001;15:351–5. https://doi.org/10.1002/ptr.833.Suche in Google Scholar PubMed

37. Muthu, AK, Sethupathy, S, Manavalan, R, Karar, P. Hypolipidemic effect of methanolic extract of Dolichos biflorus Linn. in high fat diet fed rats. Annamalai Nagar, India: NISCAIR-CSIR; 2005, 43:522–5 pp.Suche in Google Scholar

38. Hazra, B, Sarkar, R, Mandal, S, Biswas, S, Mandal, N. Studies on antioxidant and antiradical activities of Dolichos biflorus seed extract. Afr J Biotechnol 2009;8:3927–33.Suche in Google Scholar

39. Siddhuraju, P, Manian, S. The antioxidant activity and free radical-scavenging capacity of dietary phenolic extracts from horse gram (Macrotyloma uniflorum (Lam.) Verdc.) seeds. Food Chem 2007;105:950–8. https://doi.org/10.1016/j.foodchem.2007.04.040.Suche in Google Scholar

40. Suralkar, AA, Kasture, SB. Anti-allergic and anti-anaphylactic activities of Dolichos biflorus. Int J Green Pharm 2013;7. https://doi.org/10.4103/0973-8258.120205.Suche in Google Scholar

41. Fatima, SA, Baig, SG, Hasan, MM, Ahmed, S. Analgesic and anti-inflammatory activities of fixed oil of Macrotyloma uniflorum (Lam.) Verdc. in mice and rats. Pak J Pharm Sci 2018;31:581–5.Suche in Google Scholar

42. Tiselius, HG. Epidemiology and medical management of stone disease. BJU Int 2003;91:758–67. https://doi.org/10.1046/j.1464-410x.2003.04208.x.Suche in Google Scholar PubMed

43. Moe, OW. Kidney stones: pathophysiology and medical management. Lancet 2006;367:333–44. https://doi.org/10.1016/s0140-6736(06)68071-9.Suche in Google Scholar

44. Prezioso, D, Strazzullo, P, Lotti, T, Bianchi, G, Borghi, L, Caione, P, et al.. Dietary treatment of urinary risk factors for renal stone formation. a review of CLU working group. Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica. 2015;87:105–20. https://doi.org/10.4081/aiua.2015.2.105.Suche in Google Scholar PubMed

45. Batoo, AS, Dey, S, Ganaie, ZA, Bhat, MA, Mudasir, M, Nabi, B, et al.. Safety evaluation of Dolichos biflorus seed extract against ethylene glycol induced renal stone in experimental rats. J Pharmacogn Phytochem 2018;7:1229–32.10.20546/ijcmas.2018.706.041Suche in Google Scholar

46. Saha, S, Verma, RJ. Antinephrolithiatic and antioxidative efficacy of Dolichos biflorus seeds ina lithiasic rat model. Pharmaceut Biol 2015;53:16–3. https://doi.org/10.3109/13880209.2014.909501.Suche in Google Scholar PubMed

47. Saha, S, Verma, RJ. Evaluation of hydro-alcoholic extract of Dolichos biflorus seeds on inhibition of calcium oxalate crystallization. J Herb Med 2015;5:41–7. https://doi.org/10.1016/j.hermed.2014.11.001.Suche in Google Scholar

48. Patel, VB, Acharya, N. Effect of Macrotyloma uniflorum in ethylene glycol induced urolithiasis in rats. Heliyon 2020;6:e04253. https://doi.org/10.1016/j.heliyon.2020.e04253.Suche in Google Scholar PubMed PubMed Central

Received: 2022-04-26
Accepted: 2022-07-13
Published Online: 2022-08-09

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jcim-2022-0166
Schlagwörter für diesen Artikel
Cynodon dactylon; Dolichos biflorus; lithagogue; lithotriptic; urolithiasis

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Does acupuncture improve sexual dysfunction? A systematic review
  4. Non-alcoholic fatty liver disease – discussed under the light of Unani medicine
  5. Phytochemistry and pharmacology of Celastrus paniculatus Wild.: a nootropic drug
  6. Low back pain patients’ perceived effectiveness of utilizing complementary and alternative medicine: a systematic review of qualitative studies
  7. Efficacy and tolerability of Lavandula angustifolia in treating patients with the diagnosis of depression: a systematic review of randomized controlled trials
  8. Research Articles
  9. Psychobiotic interventions attenuate chronic alcohol use-mediated exacerbation of posttraumatic stress disorder in rats: the role of gut-liver axis response
  10. Evaluation of the toxicity of crude aqueous Pleurotus tuber-regium (Fr.) Singer extract in mice
  11. Effects of crude methanol extract of Adansonia digitata fruit pulp on Naja nigricollis venom-induce toxicity in Wistar rats
  12. Integrative medicine approaches to chronic depression: case studies of the recovery process with a three-step path to recovery and significant cure
  13. Antimicrobial, anti-adhesion, anti-biofilm properties of goji berry (Lycium barbarum) against periodontal bacteria: potential benefits for periodontal diseases
  14. Method development and validation for quantification of six bioactive compounds (andrographolide, columbin, piperine, gallic, paracoumaric and oleanolic acids) by HPTLC
  15. Gallic acid a flavonoid isolated from Euphorbia hirta antagonizes gamma radiation induced radiotoxicity in lymphocytes in vitro
  16. Naturopathic knowledge and approaches to managing endometriosis: a cross-sectional survey of naturopaths with experience in endometriosis care
  17. Halimeda gracilis (Kadarpassi chooranam) Phytochemical analysis and biological significance – a novel Siddha drug
  18. Trends in the St. John’s wort (Hypericum perforatum) research literature: a bibliometric analysis
  19. Use and perception of complementary and alternative medicine among Iranian psychologists
  20. Innovative histological and histochemical characterization of tongue biopsies from patients with burning mouth syndrome
  21. A randomized, double-blind, placebo-controlled, cross-over trial to evaluate the effect of EstroSense® on 2-hydroxyestrone:16α-hydroxyestrone ratio in premenopausal women
  22. Comparing the influence of foot reflexology and fasting mimicking diet on quality of life and sleep quality in obesity hypoventilation syndrome
  23. The effects of Cynodon dactylon (Poaceae family) and Dolichos biflorus (Fabaceae family) extracts on decreasing size and excretion of kidney and urinary tract stones: a randomized, double-blind controlled trial
  24. Role of Bifidobacterium spp. intake in improving depressive mood and well-being and its link to kynurenine blood level: an interventional study
  25. A randomized controlled clinical trial to evaluate safety and efficacy of a Unani formulation in the management of Kalaf (Melasma)
  26. Impact of yoga and physical exercise on psychological wellbeing among substance abusers: a randomized controlled trial
  27. A non-inferiority randomized controlled clinical trial comparing Unani formulations and PUVAsol in non-segmental vitiligo
  28. Efficacy of individualized homeopathic medicines in primary dysmenorrhea: a double-blind, randomized, placebo-controlled, clinical trial
  29. A comparative study of chemical constituents and safety of Thai herbal medicated oil formula and traditional medicated oil
  30. Efficacy of Ayurvedic treatment protocol in gouty arthritis – a clinical study
  31. Knowledge, attitude and perception of complementary and alternative system of medicine in Tamilnadu and Pudhucherry, South India
  32. Discussion Forum
  33. Time to say good-bye? Homeopathy, skeptics and thoughts on how to proceed
  34. Congress Abstracts
  35. 2022 INCAM Research Symposium
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