Amikacin alters auditory brainstem conduction time in newborns
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A. Poblano
Abstract
The purpose of this paper was to describe whether there are some relationships between amikacin serum levels and central conduction time in brainstem auditory evoked potentials (BAEP) within therapeutic range levels in newborns as index of drug toxicity in brainstem auditory centers in neonatally exposed infants. We performed a cross-sectional study to compare BAEP from 35 infants under amikacin administration and 24 control infants; both examinations were blinded to investigators. Bivariate and partial correlations were calculated between amikacin and BAEP measurements in treated infants. Amikacin determinations were within therapeutic levels.No clinical alterations in BAEP were found and no differences between amikacin-treated and control infants were found. Significant positive Pearson correlation between latency of I-III interwaves interval and amikacin Cmin serum levels was found and was present when calculations were controlled by partial correlations for gestational age at birth and Apgar score at 5 min.The findings suggest that increased amikacin levels in newborns are related to increased latencies in I-III interwave interval in infants, which may be an early index of brainstem effects of subclinical neurotoxicity of amikacin.
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
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Artikel in diesem Heft
- Telemedicine for antenatal surveillance of high-risk pregnancies with ambulatory and home fetal heart rate monitoring – an update
- The HELLP-syndrome; maternal-fetal outcome and follow up of infants
- Effect of maternal age on blood loss during parturition: a retrospective multivariate analysis of 10,053 cases
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- Accuracy of sonographic estimation of fetal weight before induction of labor in diabetic pregnancies and pregnancies with suspected fetal macrosomia
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- Amikacin alters auditory brainstem conduction time in newborns
- Triplets and quadruplets in Switzerland: comparison with singletons, and evolution over the last decade
- Maternal smoking during pregnancy and appetite control in offspring
- Sequential use of thrombolytic agents for thrombosed mitral valve prosthesis during pregnancy
- Congenital mixed malignant germ cell tumor involving cerebrum and orbit
- Jejunal atresia related to the use of toluidine blue in genetic amniocentesis in twins
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