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Congenital mixed malignant germ cell tumor involving cerebrum and orbit

  • J.-C. Lee , S.-M. Jung , A.-S. Chao and C. Hsueh
Published/Copyright: June 1, 2005
Journal of Perinatal Medicine
From the journal Volume 31 Issue 3

Abstract

Congenital intracranial tumors are rare and only account for 0.5 to 1.5% of all pediatric brain tumors. Teratoma is the most frequently encountered intracranial tumor at birth. Cephalomegaly and hydrocephalus are the usual clinical presentations. Advances in imaging techniques have improved diagnostic accuracy in congenital brain tumors. But the prognosis of a massive intracranial teratoma is always dismal. We report a congenital mixed malignant germ cell tumor in a male fetus at 27 weeks of gestation, with massive involvement of cerebrum and orbit. According to histological and immunohistochemical studies, the tumor was made up of predominantly immature teratoma combined with a yolk sac tumor. To our knowledge, such a combination has not been well documented in the literature.

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Published Online: 2005-06-01
Published in Print: 2003-05-14

Copyright © 2003 by Walter de Gruyter GmbH & Co. KG

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