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Influence of Surfactants on Release of Chlorhexidine from Hydrogels

  • Z. Vitková , J. Oremusová , A. Vitko und Ž. Bezáková
Veröffentlicht/Copyright: 5. April 2013
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Tenside Surfactants Detergents
Aus der Zeitschrift Tenside Surfactants Detergents Band 48 Heft 1

Abstract

In Slovakia chlorhexidine is available in dosage forms of solutions, creams and pastes but not in the form of hydrogels, though they are modern drug forms with many positive properties. Therefore, in this article possibilities of its formulation into hydrogels are studied. In particular, two research aims were followed. The first consisted in study of an influence of surface active agents on the release of chlorhexidine dihydrochloride from chitosan hydrogels and the second one was to design a formulation of hydrogels for local delivery of chlorhexidine to the oral cavity. To this end, surfactants from the group of alkyltrimethylammonium bromides with the length of alkyl chain C6–C18 which occupy a dominant position in the indication group of antiseptics and disinficients were analyzed with intention to use them in preparation of hydrogels. Hydrogels were prepared with 2.5% (w/w) gel-forming agent chitosan. Both the active agent and surfactants were used in 0.1% (w/w) concentration. It is shown that the surface active agents with short alkyl chain are suitable for development of chlorhexidine dihydrochloride hydrogels with controlled release.

Kurzfassung

Chlorhexidine ist in der Slowakei in Form von Lösungen, Cremes und Pasten erhältlich, aber nicht in Form von Hydrogelen, obgleich es sich um moderne Arzneimittel mit vielen positiven Eigenschaften handelt. Deshalb werden in dieser Arbeit die Möglichkeiten der Herstellung in Hydrogelen untersucht. Im Einzelnen wurden zwei Forschungsziele verfolgt. Zum ersten wurde der Einfluss oberflächenaktiver Stoffe auf die Abgabe von Chlorhexidindihydrochlorid aus Chitosanhydrogelen untersucht. Zweitens sollte eine Formulierung für Hydrogele gefunden werden, die eine lokale Abgabe von Chlorhexidine in die Mundhöhle erlaubt. Zu diesem Zweck wurden Alkyltrimethylammoniumbromide mit einer Alkylkettenlänge von C6–C18, die wichtige Positionen in der Gruppe von Antiseptika und Desinfektionsmitteln besetzen, mit der Absicht untersucht, diese für die Herstellung von Hydrogelen zu benutzen. Es wurden Hydrogele mit 2,5% (w/w) des gelbildenden Wirkstoffes Chitosan hergestellt. Sowohl der aktive Wirkstoff als auch die Tenside wurden in einer Konzentration von 0,1% eingesetzt. Es konnte gezeigt werden, dass Tenside mit kurzen Alkylketten für die Entwicklung von Chlorhexidindihydrochloridhydrogelen mit kontrollierter Wirkstoffabgabe gut geeignet sind.

Key words:: Chlorhexidine; release; hydrogel; critical micelle concentration; surfactants
Stichwörter:: Chlorhexidin; Wirkstoffabgabe; Hydrogel; kritische Mizellbildungskonzentration; Tenside
∗ Dr. J. Oremusová, Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University, Odbojárov 10, 83232 Bratislava, Slovak Republic. E-Mail:

Assoc. Prof. Zuzana Vitková, PhD. graduated from the Faculty of Pharmacy, Comenius University in Bratislava, Slovakia, in 1967. She obtained PhD degree in 1972. Since 1993 she has been acting as associate professor at the Department of Galenic Pharmacy. Research: Modern drug delivery systems and biopharmacy. She is author of numerous journal and conference papers related to these topics.

Assoc. Prof. Anton Vitko, PhD. graduated from the Faculty of Electrical Engineering and Information Technology Slovak University of Technology in Bratislava, Slovakia, in 1969. He became PhD in 1980 and associate professor in 1986. His research covers intelligent control systems, biologic systems and pharmacokinetics. He is both the author and reviewer of numerous scientific papers.

Dr. Jarmila Oremusová, PhD. graduated from the Faculty of Chemical Technology, Slovak University of Technology in Bratislava, Slovakia, in 1983. She obtained PhD degree in 1990. Since 1989 she has been acting at the Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University in Bratislava.

Assoc. Prof. Želmíra Bezáková, CSc. (PhD.) graduated from the Faculty of Pharmacy, Comenius University in Bratislava, Slovakia, in 1970. She obtained CSc. (PhD.) degree in 1985. Since 1991 she has been acting as associate professor at the Department of Pharmaceutical Chemistry. Research: study of analytical, physical and physicochemical properties and stability of new synthesized potential drugs especially with effect on cardiovascular system. She is author of numerous journal and conference papers related to these topics and also she is author of 3 monographs related to drug analysis and control.

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Received: 2010-02-11
Published Online: 2013-04-05
Published in Print: 2011-01-01

© 2011, Carl Hanser Publisher, Munich

Artikel in diesem Heft

  1. Contents/Inhalt
  2. Contents
  3. Abstracts
  4. Abstracts
  5. Editorial
  6. Rückblick auf zwei erfolgreiche Jahre 2009/2010
  7. Application
  8. Surface Activity and Adsorption Properties of New Perfluorinated Carbohydrate Surfactants
  9. Novel Surfactants
  10. Study of Glycerol Residue as a Carbon Source for Production of Rhamnolipids by Pseudomonas aeruginosa (ATCC 10145)
  11. Study of CLSI-M44-A Disk Diffusion Method for Determining the Susceptibility of Candida Species against Novel Complexes Derived from Copper Stearate with 2-Amino Benzothiazoles
  12. European Detergents Conference
  13. Bicontinuous Microemulsion as Reaction Medium for ω-Transaminase Catalysed Biotransformations
  14. Physical Chemistry
  15. SAXS Study on Azithromycin Loaded Nonionic Microemulsions
  16. Effects of Alkaline Cations on Self-assembly of Cetylpyridinium Surfactants
  17. Influence of Surfactants on Release of Chlorhexidine from Hydrogels
  18. Environmental Chemistry
  19. Influence of Surfactants on the Performance of Calcium Phosphate Scale Inhibitors
  20. Technical Chemistry
  21. Preparation and Characterization of a Phosphorous Free and Non-Nitrogen Antiscalant in Industrial Cooling Systems
  22. Preparation and Characterization of Pillared Derivatives from δ-Layered Sodium Disilicate and their Tribological Properties in Liquid Paraffin
  23. Synthesis
  24. An Efficient and Mild Procedure for the Preparation of Aldonic Acids via Oxidation of D-Sucrose by Employing N-Bromophthalimide Oxidant and Micellar System
  25. Synthesis and Properties of Some N-Acylethylenediamine Triacetic Acid Chelating Surfactants
  26. Conference and Meeting Report
  27. Sixth European Detergents Conference Report
  28. GDCh-Intensive Course Surfactants: Detergents, Cosmetics, Technical Applications
https://doi.org/10.3139/113.110103
Schlagwörter für diesen Artikel
Chlorhexidine; release; hydrogel; critical micelle concentration; surfactants

Artikel in diesem Heft

  1. Contents/Inhalt
  2. Contents
  3. Abstracts
  4. Abstracts
  5. Editorial
  6. Rückblick auf zwei erfolgreiche Jahre 2009/2010
  7. Application
  8. Surface Activity and Adsorption Properties of New Perfluorinated Carbohydrate Surfactants
  9. Novel Surfactants
  10. Study of Glycerol Residue as a Carbon Source for Production of Rhamnolipids by Pseudomonas aeruginosa (ATCC 10145)
  11. Study of CLSI-M44-A Disk Diffusion Method for Determining the Susceptibility of Candida Species against Novel Complexes Derived from Copper Stearate with 2-Amino Benzothiazoles
  12. European Detergents Conference
  13. Bicontinuous Microemulsion as Reaction Medium for ω-Transaminase Catalysed Biotransformations
  14. Physical Chemistry
  15. SAXS Study on Azithromycin Loaded Nonionic Microemulsions
  16. Effects of Alkaline Cations on Self-assembly of Cetylpyridinium Surfactants
  17. Influence of Surfactants on Release of Chlorhexidine from Hydrogels
  18. Environmental Chemistry
  19. Influence of Surfactants on the Performance of Calcium Phosphate Scale Inhibitors
  20. Technical Chemistry
  21. Preparation and Characterization of a Phosphorous Free and Non-Nitrogen Antiscalant in Industrial Cooling Systems
  22. Preparation and Characterization of Pillared Derivatives from δ-Layered Sodium Disilicate and their Tribological Properties in Liquid Paraffin
  23. Synthesis
  24. An Efficient and Mild Procedure for the Preparation of Aldonic Acids via Oxidation of D-Sucrose by Employing N-Bromophthalimide Oxidant and Micellar System
  25. Synthesis and Properties of Some N-Acylethylenediamine Triacetic Acid Chelating Surfactants
  26. Conference and Meeting Report
  27. Sixth European Detergents Conference Report
  28. GDCh-Intensive Course Surfactants: Detergents, Cosmetics, Technical Applications
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