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SAXS Study on Azithromycin Loaded Nonionic Microemulsions

  • M. Fanun und O. Glatter
Veröffentlicht/Copyright: 5. April 2013
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Tenside Surfactants Detergents
Aus der Zeitschrift Tenside Surfactants Detergents Band 48 Heft 1

Abstract

Structure of water/propylene glycol/ethoxylated mono-di-glyceride/peppermint oil/ethanol microemulsions solubilizing azithromycin has been investigated at room temperature by small-angle X-ray scattering (SAXS) technique. The scattering data were evaluated by Indirect Fourier Transformation (IFT) or Generalized Indirect Fourier Transformation (GIFT) methods depending on the aqueous phase content. The growth of the microemulsions droplets by increasing the water content and the effect of azithromycin incorporation in the microemulsions were investigated. The Indirect Fourier Transformation gives the real space pair-distance distribution function: a facile way for the quantitative estimation of structure parameters of the microemulsions. It was found that the size of the microemulsion aggregates or repeating distances in the microemulsion increases with the aqueous phase content. The maximum diameter of the drug free and drug loaded microemulsions aggregates depend on their microstructure. The values of the effective interaction radius of the microemulsions are higher for the drug free compared to the drug loaded microemulsions aggregates.

Kurzfassung

Die Struktur von Mikroemulsionen aus Wasser, Propylenglykol, ethoxilierten Mono-di-glyceriden, Pfefferminzöl und Ethanol, die Azithromycin lösen, wurde bei Raumtemperatur mit Hilfe der Röntgenkleinwinkelstreuung (SAXS) untersucht. Die Streudaten wurden mittels indirekter Fouriertransformation (IFT) oder generalisierter indirekter Fouriertransformation (GIFT) in Abhängigkeit von dem Wassergehalt ausgewertet. Das Wachstum der Mikroemulsionstropfen bei steigendem Wassergehalt und der Einfluss von Azithromycin-Zugaben in die Mikroemulsion wurden untersucht. Da die indirekte Fourier Transformation die Abstands-Verteilungsfunktion im Realraum liefert, lassen sich so leicht quantitative Aussagen über die Strukturparameter der Mikroemulsion gewinnen. Es wurde beobachtet, dass sich die Abmessungen der Mikroemulsionsaggregate oder die Wiederholabstände in der Mikroemulsion mit dem Wassergehalt zunehmen. Der maximale Durchmesser der freien und der mit Wirkstoff beladenen Mikroemulsionsaggregate hängt von ihrer Mikrostruktur ab. Der effektive Wechselwirkungsradius der Mikroemulsionen ist für die wirkstofffreien Aggregate größer als für die mit Wirkstoff beladenen Aggregate.

Key words:: U-type microemulsions; drug delivery; GIFT; effective interaction radius; particle size
Stichwörter:: U-förmige Mikroemulsion; Wirkstoffabgabe; GIFT; effektiver Wechselwirkungsradius; Partikelgröße
∗ Dr. M. Fanun, Colloids and Surfaces Research Center, Al-Quds University, 51000 East Jerusalem, Palestine, Tel.: +97222799753, Fax: + 97222796960. E-Mail: or

Dr. Monzer Fanun received his Ph.D in 2003 at the Hebrew University of Jerusalem in applied chemistry. He is a professor and head of the colloids and surfaces research center at Al-Quds University, East Jerusalem, Palestine. His research focuses on colloidal systems for health care products and surfactant-based alternatives to organic solvents.

Dr. Otto Glatter got his Ph.D. in 1972 at the Technical University of Graz and University of Graz in Technical Physics. He is a professor for Physical Chemistry since 1992 in the Department of Chemistry of the Karl-Franzens-University in Graz, Austria and is leader of the research group on scattering methods. His research focuses on scattering methods and their application to soft condensed matter.

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Received: 2010-05-05
Published Online: 2013-04-05
Published in Print: 2011-01-01

© 2011, Carl Hanser Publisher, Munich

Artikel in diesem Heft

  1. Contents/Inhalt
  2. Contents
  3. Abstracts
  4. Abstracts
  5. Editorial
  6. Rückblick auf zwei erfolgreiche Jahre 2009/2010
  7. Application
  8. Surface Activity and Adsorption Properties of New Perfluorinated Carbohydrate Surfactants
  9. Novel Surfactants
  10. Study of Glycerol Residue as a Carbon Source for Production of Rhamnolipids by Pseudomonas aeruginosa (ATCC 10145)
  11. Study of CLSI-M44-A Disk Diffusion Method for Determining the Susceptibility of Candida Species against Novel Complexes Derived from Copper Stearate with 2-Amino Benzothiazoles
  12. European Detergents Conference
  13. Bicontinuous Microemulsion as Reaction Medium for ω-Transaminase Catalysed Biotransformations
  14. Physical Chemistry
  15. SAXS Study on Azithromycin Loaded Nonionic Microemulsions
  16. Effects of Alkaline Cations on Self-assembly of Cetylpyridinium Surfactants
  17. Influence of Surfactants on Release of Chlorhexidine from Hydrogels
  18. Environmental Chemistry
  19. Influence of Surfactants on the Performance of Calcium Phosphate Scale Inhibitors
  20. Technical Chemistry
  21. Preparation and Characterization of a Phosphorous Free and Non-Nitrogen Antiscalant in Industrial Cooling Systems
  22. Preparation and Characterization of Pillared Derivatives from δ-Layered Sodium Disilicate and their Tribological Properties in Liquid Paraffin
  23. Synthesis
  24. An Efficient and Mild Procedure for the Preparation of Aldonic Acids via Oxidation of D-Sucrose by Employing N-Bromophthalimide Oxidant and Micellar System
  25. Synthesis and Properties of Some N-Acylethylenediamine Triacetic Acid Chelating Surfactants
  26. Conference and Meeting Report
  27. Sixth European Detergents Conference Report
  28. GDCh-Intensive Course Surfactants: Detergents, Cosmetics, Technical Applications
https://doi.org/10.3139/113.110101
Schlagwörter für diesen Artikel
U-type microemulsions; drug delivery; GIFT; effective interaction radius; particle size

Artikel in diesem Heft

  1. Contents/Inhalt
  2. Contents
  3. Abstracts
  4. Abstracts
  5. Editorial
  6. Rückblick auf zwei erfolgreiche Jahre 2009/2010
  7. Application
  8. Surface Activity and Adsorption Properties of New Perfluorinated Carbohydrate Surfactants
  9. Novel Surfactants
  10. Study of Glycerol Residue as a Carbon Source for Production of Rhamnolipids by Pseudomonas aeruginosa (ATCC 10145)
  11. Study of CLSI-M44-A Disk Diffusion Method for Determining the Susceptibility of Candida Species against Novel Complexes Derived from Copper Stearate with 2-Amino Benzothiazoles
  12. European Detergents Conference
  13. Bicontinuous Microemulsion as Reaction Medium for ω-Transaminase Catalysed Biotransformations
  14. Physical Chemistry
  15. SAXS Study on Azithromycin Loaded Nonionic Microemulsions
  16. Effects of Alkaline Cations on Self-assembly of Cetylpyridinium Surfactants
  17. Influence of Surfactants on Release of Chlorhexidine from Hydrogels
  18. Environmental Chemistry
  19. Influence of Surfactants on the Performance of Calcium Phosphate Scale Inhibitors
  20. Technical Chemistry
  21. Preparation and Characterization of a Phosphorous Free and Non-Nitrogen Antiscalant in Industrial Cooling Systems
  22. Preparation and Characterization of Pillared Derivatives from δ-Layered Sodium Disilicate and their Tribological Properties in Liquid Paraffin
  23. Synthesis
  24. An Efficient and Mild Procedure for the Preparation of Aldonic Acids via Oxidation of D-Sucrose by Employing N-Bromophthalimide Oxidant and Micellar System
  25. Synthesis and Properties of Some N-Acylethylenediamine Triacetic Acid Chelating Surfactants
  26. Conference and Meeting Report
  27. Sixth European Detergents Conference Report
  28. GDCh-Intensive Course Surfactants: Detergents, Cosmetics, Technical Applications
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