Lidocaine hydrochloride preparations with ionic and non-ionic polymers assessed at standard and increased skin surface temperatures
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Witold Musial
,
Vanja Kokol
Abstract
In this study, the release of lidocaine hydrochloride was assessed considering the use of both the ionic and the non-ionic polymeric carrier at temperatures of 22°C, 32°C, and 42°C; temperature of 32°C was chosen as the reference surface body temperature. The obtained release rates and respective amounts of lidocaine hydrochloride loaded both to methylcellulose beads and polyacrylic acid beads were compared with respective viscosity, pH and conductivity of the studied systems. The release of lidocaine hydrochloride from the methylcellulose system is influenced by temperature; with the increase of temperature the release rate decreases whereas the viscosity increases. In the polyacrylic acid system, release rates are lower, however, in the first stage they are slightly increasing with the increase of temperature. The final amount of released drug after 24 h increases with the temperature of the release process environment, and it is higher in case of a methylcellulose system. The maximum differences between the released amounts for methylcellulose were in the range of 15 %, whereas in case of polyacrylic acid, the difference was approximately 12 %. Thus, this research is important for patients with differentiated skin surface temperature conditions to whom a local analgesic is to be applied.
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© 2009 Institute of Chemistry, Slovak Academy of Sciences
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Artikel in diesem Heft
- Immobilization of urease in poly(1-vinyl imidazole)/poly(acrylic acid) network
- Anodic reactions of sulphate in molten salts
- Fuels obtained by thermal cracking of individual and mixed polymers
- Synthesis, structure, and solvent-extraction properties of tridentate oxime ligands and their cobalt(II), nickel(II), copper(II), zinc(II) complexes
- Properties of a poly(ethylene glycol)-block-poly(γ-benzyl l-glutamate)-graft-poly(ethylene glycol) copolymer membrane
- Influence of tungsten sources on the synthesis and properties of ammonium dioxothiotungstate
- A Raman spectroscopy study on differently deposited DLC layers in pulse arc system
- 1,7′-dimethyl-2′-propyl-1H,3′H-2,5′-bibenzo[d]imidazole as a corrosion inhibitor of mild steel in 1 M HCl
- The role of acidity profile in the nanotubular growth of polyaniline
- Direct sulfenylation of acetone with benzothiazolesulfenamides to benzothiazolylthio-substituted alkylaminopropene: synthesis and application
- Substituted pyridopyrimidinones. Part 5. Behavior of 2-hydroxy-4-oxo-4H-pyrido[1,2-α]pyrimidine-3-carbaldehyde in nucleophilic condensation reactions
- Lidocaine hydrochloride preparations with ionic and non-ionic polymers assessed at standard and increased skin surface temperatures
- Phase separation in non-ionic surfactant Triton X-100 solutions in the presence of phenol
- Phase formation in sodium dodecylsulfate solutions in the presence of salicylic acid for preconcentration purposes
- Numerical properties of equations involving high-order derivatives of pressure with respect to volume
- Synthesis and characterization of conducting copolymer of (N 1,N 3-bis(thiophene-3-ylmethylene)benzene-1,3-diamine-co-3,4-ethylenedioxythiophene)
- Intercalation of non-aromatic heterocyclic amines into layered zirconium glycine-N,N-dimethylphosphonate
- Kinetics of catalytic Meerwein-Ponndorf-Verley reduction of aldehydes and ketones using boron triethoxide
