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Syzygium cumini Seed Extract Protects the Liver Against Lipid Peroxidation with Concurrent Amelioration of Hepatic Enzymes and Lipid Profile of Alcoholic Rats
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Shahdat Hossain
Veröffentlicht/Copyright:
8. Februar 2011
The in vitro oxidative stress induced by ethanol/Fenton’s reaction in rat liver homogenates decreased significantly in the presence of Syzygium cumini seed extract, suggesting the protective effect of the seed extract against the oxidative stress in liver. To corroborate the in vitro effects by an in vivo experiment, 24 rats were divided into four groups: control, S. cumini seed-extract-administered (SE), 15% ethanol-fed (Alc) and Alc+SE rats. The oral administration of the extract (400 mg/kg BW.day) for 7 weeks significantly decreased the levels of liver LPO in the Alc+SE rats, suggesting that S. cumini seed not only obstructed the in vitro free radical production and subsequent oxidative stress, but also inhibited their in vivo formation. The oral administration of extract also reduced the enzyme activities of serum gammaglutamyl transferase, glutamate oxaloacetate transaminase and glutamate pyruvate transaminase and the levels of serum creatinine and blood urea nitrogen, serum/liver triglycerides and total cholesterol of the alcoholic rats. The levels of fecal cholesterol were increased by the extract. Fatty degenerations in liver and kidney were absent with S. cumini seed extract treatment. The results suggest that S. cumini seed may be a potential therapy for alcoholics and related dysfunctions by restraining oxidative stress.
Keywords: alcoholics; Syzygium cumini seed extract; lipid peroxidation; hepatotoxicity and hypercholesterolemia
Published Online: 2011-2-8
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
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Artikel in diesem Heft
- Research Article
- Syzygium cumini Seed Extract Protects the Liver Against Lipid Peroxidation with Concurrent Amelioration of Hepatic Enzymes and Lipid Profile of Alcoholic Rats
- Antihypertensive and Vasorelaxant Effects of Cinnamomum zeylanicum Stem Bark Aqueous Extract in Rats
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Schlagwörter für diesen Artikel
alcoholics;
Syzygium cumini seed extract;
lipid peroxidation;
hepatotoxicity and hypercholesterolemia
Artikel in diesem Heft
- Research Article
- Syzygium cumini Seed Extract Protects the Liver Against Lipid Peroxidation with Concurrent Amelioration of Hepatic Enzymes and Lipid Profile of Alcoholic Rats
- Antihypertensive and Vasorelaxant Effects of Cinnamomum zeylanicum Stem Bark Aqueous Extract in Rats
- Glucose Uptake-Enhancing Activity of the Ethyl Acetate Extract of Dennettia tripetala in 3T3-L1 Adipocytes
- Fenugreek Supplementation Imparts Erythrocyte Resistance to Cypermethrin Induced Oxidative Changes In Vivo
- Evaluation of Hypoglycemic Activity and Toxicity Profiles of the Leaves of Ficus deltoidea in Rodents
- Influence of Benefits, Barriers and Cues to Action for Complementary and Alternative Medicine Use among University Students
- In vitro (?-Glucosidase and ?-Amylase Inhibition) and in vivo Antidiabetic Property of Phytic Acid (IP6) in Streptozotocin-Nicotinamide-Induced Type 2 Diabetes Mellitus (NIDDM) in Rats
- Effects of Improved Self-Appraisal and Mood Factors on Weight Loss in Obese Women Initiating Supported Exercise
- Chemical Characterization and Evaluation of the Hypoglycemic Effect of Fructooligosaccharides from Psacalium decompositum
- Antibacterial and Antioxidant Activities of Synedrella nodiflora (L.) Gaertn. (Asteraceae)
- Oxygen Bar Effectiveness: A Randomized Quantitative Study
- The Role of Complementary Indigenous Malay Therapies: Perspectives from Palliative Care Patients
- Anti-Inflammatory, Antipyretic and Antioxidant Effect of Some Medicinal Plant Extracts
- Antihyperglycaemic And Renoprotective Effect of Boerhaavia diffusa L. in Experimental Diabetic Rats
- CAM in Canadian Hospitals: The New Frontier?
- Herbal Tonic Does Not Inhibit Estrogen Receptor Negative Mammary Tumor Development in a Transgenic Mouse Model
- Antioxidant and Free Radical Scavenging Activities of Some Fruits
- Pycnogenol (PYC) Induces Apoptosis in Human Fibrosarcoma (HFS) Cells Under Metal-mediated Oxidative Stress
- Evaluation of Anti-inflammatory and Antioxidant Activity of Premna integrifolia Root
- Impact of Mind Body Therapies on Vascular Endothelial Dysfunction and Implications for Cardiovacular Disease Management
- Studies on the Antiulcer and Gastrointestinal Effects of Stem Bark Extract of Bridelia ferruginea
- Study of Antiobesity Effects of Ethanolic and Water Extracts of Grapes Seeds
- Effect of Wrightia tinctoria and Parthenocissus quinquefolia on blood glucose and Insulin levels in the Zucker Diabetic Rat Model
- Short Communication on Medicinal Herbs
- Potent Hypoglycemic Effect of Nigerian Anti-Diabetic Medicinal Plants
- Hepatoprotective Effects and Antioxidant Role of Scutia myrtina on Paracetamol Induced Hepatotoxicity in Rats
- Extract of North American Ginseng (Panax Quinquefolius), Administered to Leukemic, Juvenile Mice Extends their Life Span
- Hepatoprotective Activity of Cyperus tegetum Rhizome Against Paracetamol-Induced Liver Damage in Rats
- Review Article
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- Case Report
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