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Fenugreek Supplementation Imparts Erythrocyte Resistance to Cypermethrin Induced Oxidative Changes In Vivo
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Sushma Navayath
Published/Copyright:
February 10, 2011
Abstract
Erythrocytes are excellent model to study the xenobiotic induced oxidative changes. Pyrethroid pesticides are increasingly being used in insecticidal preparations from the simple mosquito coils to house hold aerosols to sophisticated ultra low volume foggers and sprays. Cypermethrin a Type II pyrethroid pesticide is used widely in pest control. Fenugreek is a potent antioxidant. We have evaluated the potential of aqueous extract of germinated fenugreek seeds in counteracting cypermethrin induced oxidative changes in erythrocytes of male Wistar rats. Male Wistar rats were treated with 1/10 LD50 (25mg/kg body weight) of cypermethrin and 10 percent aqueous extract of germinated fenugreek for 60 days. Cypermethrin treatment caused significant decrease in non enzymatic antioxidants, glutathione (GSH), vitamin E, vitamin C, increased methemoglobin formation in erythrocytes and increased their mechanical fragility. Treatment with fenugreek reversed the cypermethrin induced oxidative changes in erythrocytes and restored all the parameters to near normal levels. The overall results reveal the ameliorating effect of aqueous extract of germinated fenugreek on cypermethrin induced toxicity in erythrocytes.
Published Online: 2011-02-10
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
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Keywords for this article
antioxidants;
cypermethrin;
fenugreek;
methemoglobin;
osmotic fragility;
ROS
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- Herbal Tonic Does Not Inhibit Estrogen Receptor Negative Mammary Tumor Development in a Transgenic Mouse Model
- Evaluation of Anti-inflammatory and Antioxidant Activity of Premna integrifolia Root
- Extract of North American Ginseng (Panax Quinquefolius), Administered to Leukemic, Juvenile Mice Extends their Life Span
- The Role of Complementary Indigenous Malay Therapies: Perspectives from Palliative Care Patients
- Does Meditation Play an Integral Role in Achieving High-Level Wellness as Defined by Travis and Ryan (2004)?
- Effects of Improved Self-Appraisal and Mood Factors on Weight Loss in Obese Women Initiating Supported Exercise
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