Two Case Reports on the Use of Genistein Combined Polysaccharide (GCP) Against Bladder Cancer Recurrence
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Jillian L Capodice
, A S Cammack , James M McKiernan and Aaron E Katz
Abstract
We followed two subjects with resected stage Ta superficial transitional cell carcinoma (TCC) of the bladder who had not received intravesicle bacillus Calmette-Guerin (BCG) and received supplementation with the agent Genistein Combined Polysaccharide (GCP) in an IRB approved study. The observation period was 12 months for both cases. After the yearly oral dosage of GCP, there was no recurrence in either of the subjects as determined by cytoscopy, urine cytology, and fluorescence in-situ hybridization analysis of urine (UrovysionTM FISH Assay). The intravenous pyelogram (IVP), obtained at baseline and after 12 months, was also negative. There were no adverse events over the course of treatment and had full patient compliance and tolerability of the GCP agent in both cases.
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
Articles in the same Issue
- Research Article
- Anti-Inflammatory, Antipyretic and Antioxidant Effect of Some Medicinal Plant Extracts
- Two Case Reports on the Use of Genistein Combined Polysaccharide (GCP) Against Bladder Cancer Recurrence
- Herbal Tonic Does Not Inhibit Estrogen Receptor Negative Mammary Tumor Development in a Transgenic Mouse Model
- Evaluation of Anti-inflammatory and Antioxidant Activity of Premna integrifolia Root
- Extract of North American Ginseng (Panax Quinquefolius), Administered to Leukemic, Juvenile Mice Extends their Life Span
- The Role of Complementary Indigenous Malay Therapies: Perspectives from Palliative Care Patients
- Does Meditation Play an Integral Role in Achieving High-Level Wellness as Defined by Travis and Ryan (2004)?
- Effects of Improved Self-Appraisal and Mood Factors on Weight Loss in Obese Women Initiating Supported Exercise
- Hepatoprotective Activity of Cyperus tegetum Rhizome Against Paracetamol-Induced Liver Damage in Rats
- Effects of Panax Notoginseng (Chinese Ginseng) and Acute Exercise on Postprandial Glycemia in Non-diabetic Adults
- Combination Treatment of People with Multiple Sclerosis based on Collaboration between Conventional Healthcare Providers and Alternative Practitioners--Patient Perspectives on Outcomes
- Chemical Characterization and Evaluation of the Hypoglycemic Effect of Fructooligosaccharides from Psacalium decompositum
- Oxygen Bar Effectiveness: A Randomized Quantitative Study
- Fenugreek Supplementation Imparts Erythrocyte Resistance to Cypermethrin Induced Oxidative Changes In Vivo
- Glucose Uptake-Enhancing Activity of the Ethyl Acetate Extract of Dennettia tripetala in 3T3-L1 Adipocytes
- Syzygium cumini Seed Extract Protects the Liver Against Lipid Peroxidation with Concurrent Amelioration of Hepatic Enzymes and Lipid Profile of Alcoholic Rats
- Impact of Mind Body Therapies on Vascular Endothelial Dysfunction and Implications for Cardiovacular Disease Management
- Hepatoprotective Effects and Antioxidant Role of Scutia myrtina on Paracetamol Induced Hepatotoxicity in Rats
- Extract of Valerian Root (Valeriana Officinalis L.) vs. Placebo in Treatment of Obsessive-Compulsive Disorder: A Randomized Double-Blind Study
- CAM in Canadian Hospitals: The New Frontier?
- Evaluation of Hypoglycemic Activity and Toxicity Profiles of the Leaves of Ficus deltoidea in Rodents
- Potent Hypoglycemic Effect of Nigerian Anti-Diabetic Medicinal Plants
- In vitro (α-Glucosidase and α-Amylase Inhibition) and in vivo Antidiabetic Property of Phytic Acid (IP6) in Streptozotocin-Nicotinamide-Induced Type 2 Diabetes Mellitus (NIDDM) in Rats
- Antihypertensive and Vasorelaxant Effects of Cinnamomum zeylanicum Stem Bark Aqueous Extract in Rats
- Antibacterial and Antioxidant Activities of Synedrella nodiflora (L.) Gaertn. (Asteraceae)
- Studies on the Antiulcer and Gastrointestinal Effects of Stem Bark Extract of Bridelia ferruginea
- Study of Antiobesity Effects of Ethanolic and Water Extracts of Grapes Seeds
- Influence of Benefits, Barriers and Cues to Action for Complementary and Alternative Medicine Use among University Students
- Antioxidant and Free Radical Scavenging Activities of Some Fruits
- Pycnogenol (PYC) Induces Apoptosis in Human Fibrosarcoma (HFS) Cells Under Metal-mediated Oxidative Stress
- Effect of Chloroform and Aqueous Basic Fraction of Ethanolic Extract from Apium graveolens l. In Experimentally-Induced Hyperlipidemia in Rats
- Antihyperglycaemic And Renoprotective Effect of Boerhaavia diffusa L. in Experimental Diabetic Rats
- Effect of Wrightia tinctoria and Parthenocissus quinquefolia on blood glucose and Insulin levels in the Zucker Diabetic Rat Model
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- Pharmacological Study of the Effect of Licorice Alone and in Combination with Diclofenac Sodium on Hepatotoxicity-induced Experimentally in Rats.
Articles in the same Issue
- Research Article
- Anti-Inflammatory, Antipyretic and Antioxidant Effect of Some Medicinal Plant Extracts
- Two Case Reports on the Use of Genistein Combined Polysaccharide (GCP) Against Bladder Cancer Recurrence
- Herbal Tonic Does Not Inhibit Estrogen Receptor Negative Mammary Tumor Development in a Transgenic Mouse Model
- Evaluation of Anti-inflammatory and Antioxidant Activity of Premna integrifolia Root
- Extract of North American Ginseng (Panax Quinquefolius), Administered to Leukemic, Juvenile Mice Extends their Life Span
- The Role of Complementary Indigenous Malay Therapies: Perspectives from Palliative Care Patients
- Does Meditation Play an Integral Role in Achieving High-Level Wellness as Defined by Travis and Ryan (2004)?
- Effects of Improved Self-Appraisal and Mood Factors on Weight Loss in Obese Women Initiating Supported Exercise
- Hepatoprotective Activity of Cyperus tegetum Rhizome Against Paracetamol-Induced Liver Damage in Rats
- Effects of Panax Notoginseng (Chinese Ginseng) and Acute Exercise on Postprandial Glycemia in Non-diabetic Adults
- Combination Treatment of People with Multiple Sclerosis based on Collaboration between Conventional Healthcare Providers and Alternative Practitioners--Patient Perspectives on Outcomes
- Chemical Characterization and Evaluation of the Hypoglycemic Effect of Fructooligosaccharides from Psacalium decompositum
- Oxygen Bar Effectiveness: A Randomized Quantitative Study
- Fenugreek Supplementation Imparts Erythrocyte Resistance to Cypermethrin Induced Oxidative Changes In Vivo
- Glucose Uptake-Enhancing Activity of the Ethyl Acetate Extract of Dennettia tripetala in 3T3-L1 Adipocytes
- Syzygium cumini Seed Extract Protects the Liver Against Lipid Peroxidation with Concurrent Amelioration of Hepatic Enzymes and Lipid Profile of Alcoholic Rats
- Impact of Mind Body Therapies on Vascular Endothelial Dysfunction and Implications for Cardiovacular Disease Management
- Hepatoprotective Effects and Antioxidant Role of Scutia myrtina on Paracetamol Induced Hepatotoxicity in Rats
- Extract of Valerian Root (Valeriana Officinalis L.) vs. Placebo in Treatment of Obsessive-Compulsive Disorder: A Randomized Double-Blind Study
- CAM in Canadian Hospitals: The New Frontier?
- Evaluation of Hypoglycemic Activity and Toxicity Profiles of the Leaves of Ficus deltoidea in Rodents
- Potent Hypoglycemic Effect of Nigerian Anti-Diabetic Medicinal Plants
- In vitro (α-Glucosidase and α-Amylase Inhibition) and in vivo Antidiabetic Property of Phytic Acid (IP6) in Streptozotocin-Nicotinamide-Induced Type 2 Diabetes Mellitus (NIDDM) in Rats
- Antihypertensive and Vasorelaxant Effects of Cinnamomum zeylanicum Stem Bark Aqueous Extract in Rats
- Antibacterial and Antioxidant Activities of Synedrella nodiflora (L.) Gaertn. (Asteraceae)
- Studies on the Antiulcer and Gastrointestinal Effects of Stem Bark Extract of Bridelia ferruginea
- Study of Antiobesity Effects of Ethanolic and Water Extracts of Grapes Seeds
- Influence of Benefits, Barriers and Cues to Action for Complementary and Alternative Medicine Use among University Students
- Antioxidant and Free Radical Scavenging Activities of Some Fruits
- Pycnogenol (PYC) Induces Apoptosis in Human Fibrosarcoma (HFS) Cells Under Metal-mediated Oxidative Stress
- Effect of Chloroform and Aqueous Basic Fraction of Ethanolic Extract from Apium graveolens l. In Experimentally-Induced Hyperlipidemia in Rats
- Antihyperglycaemic And Renoprotective Effect of Boerhaavia diffusa L. in Experimental Diabetic Rats
- Effect of Wrightia tinctoria and Parthenocissus quinquefolia on blood glucose and Insulin levels in the Zucker Diabetic Rat Model
- Antioxidant Activity of Combined Ethanolic Extract of Eclipta alba and Piper longum Linn
- Pharmacological Study of the Effect of Licorice Alone and in Combination with Diclofenac Sodium on Hepatotoxicity-induced Experimentally in Rats.