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Herbal Tonic Does Not Inhibit Estrogen Receptor Negative Mammary Tumor Development in a Transgenic Mouse Model
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L. Michelle Bennett
Veröffentlicht/Copyright:
7. Juni 2011
Women who are diagnosed with breast cancer often self-administer complementary and alternative medicines to augment their conventional treatments, improve health, or prevent recurrence. Flor-Essence® herbal tonic is a complex mixture of eight herbal extracts used by cancer patients because of anecdotal evidence that it can treat or prevent disease. In this study four experimental groups of female MMTV-Neu mice were left untreated or treated with 3% Flor-Essence® in utero, from birth until 5 weeks of age, or throughout their lifetime. Palpable mammary tumor incidence and body weight was determined weekly for each group. The mice were sacrificed at 28 weeks of age and mammary tumors were enumerated to determine average tumor incidence and multiplicity for each group. Female mice exposed to Flor-Essence® herbal tonic in utero weighed significantly more than the control group (p < 0.001). The average tumor incidence and tumor multiplicity in the experimental mice treated with Flor-Essence® herbal tonic did not differ from the control animals. Flor-Essence® does not inhibit mammary tumor incidence or mammary tumor multiplicity in MMTV-Neu transgenic mice. Flor-Essence® exposure in utero causes increased body weight in experimental animals. This conclusion challenges widely available anecdotal information as well as the hopes of the consumer that this product will inhibit or suppress tumor development.
Keywords: complementary and alternative medicine; MMTV-Neu; herbal tonic; mammary tumors; transgenic; mouse; dietary supplement; Essiac
Published Online: 2011-6-7
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
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Schlagwörter für diesen Artikel
complementary and alternative medicine;
MMTV-Neu;
herbal tonic;
mammary tumors;
transgenic;
mouse;
dietary supplement;
Essiac
Artikel in diesem Heft
- Research Article
- Syzygium cumini Seed Extract Protects the Liver Against Lipid Peroxidation with Concurrent Amelioration of Hepatic Enzymes and Lipid Profile of Alcoholic Rats
- Antihypertensive and Vasorelaxant Effects of Cinnamomum zeylanicum Stem Bark Aqueous Extract in Rats
- Glucose Uptake-Enhancing Activity of the Ethyl Acetate Extract of Dennettia tripetala in 3T3-L1 Adipocytes
- Fenugreek Supplementation Imparts Erythrocyte Resistance to Cypermethrin Induced Oxidative Changes In Vivo
- Evaluation of Hypoglycemic Activity and Toxicity Profiles of the Leaves of Ficus deltoidea in Rodents
- Influence of Benefits, Barriers and Cues to Action for Complementary and Alternative Medicine Use among University Students
- In vitro (?-Glucosidase and ?-Amylase Inhibition) and in vivo Antidiabetic Property of Phytic Acid (IP6) in Streptozotocin-Nicotinamide-Induced Type 2 Diabetes Mellitus (NIDDM) in Rats
- Effects of Improved Self-Appraisal and Mood Factors on Weight Loss in Obese Women Initiating Supported Exercise
- Chemical Characterization and Evaluation of the Hypoglycemic Effect of Fructooligosaccharides from Psacalium decompositum
- Antibacterial and Antioxidant Activities of Synedrella nodiflora (L.) Gaertn. (Asteraceae)
- Oxygen Bar Effectiveness: A Randomized Quantitative Study
- The Role of Complementary Indigenous Malay Therapies: Perspectives from Palliative Care Patients
- Anti-Inflammatory, Antipyretic and Antioxidant Effect of Some Medicinal Plant Extracts
- Antihyperglycaemic And Renoprotective Effect of Boerhaavia diffusa L. in Experimental Diabetic Rats
- CAM in Canadian Hospitals: The New Frontier?
- Herbal Tonic Does Not Inhibit Estrogen Receptor Negative Mammary Tumor Development in a Transgenic Mouse Model
- Antioxidant and Free Radical Scavenging Activities of Some Fruits
- Pycnogenol (PYC) Induces Apoptosis in Human Fibrosarcoma (HFS) Cells Under Metal-mediated Oxidative Stress
- Evaluation of Anti-inflammatory and Antioxidant Activity of Premna integrifolia Root
- Impact of Mind Body Therapies on Vascular Endothelial Dysfunction and Implications for Cardiovacular Disease Management
- Studies on the Antiulcer and Gastrointestinal Effects of Stem Bark Extract of Bridelia ferruginea
- Study of Antiobesity Effects of Ethanolic and Water Extracts of Grapes Seeds
- Effect of Wrightia tinctoria and Parthenocissus quinquefolia on blood glucose and Insulin levels in the Zucker Diabetic Rat Model
- Short Communication on Medicinal Herbs
- Potent Hypoglycemic Effect of Nigerian Anti-Diabetic Medicinal Plants
- Hepatoprotective Effects and Antioxidant Role of Scutia myrtina on Paracetamol Induced Hepatotoxicity in Rats
- Extract of North American Ginseng (Panax Quinquefolius), Administered to Leukemic, Juvenile Mice Extends their Life Span
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