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Toxic effects due to exposure heavy metals and increased health risk assessment (leukemia)

  • Methaq hadi Lafta , Arghavan Afra , Indrajit Patra , Abduladheem Turki Jalil , Mohammad Javad Mohammadi EMAIL logo , Aiman Mohammed Baqir Al-Dhalimy , Shukhrat Ziyadullaev , Fatemeh Kiani , Hafez Ajam Ekrami and Parisa Asban EMAIL logo
Published/Copyright: December 29, 2022

Abstract

Heavy metals (HM) are among the elements that are rare in nature and threaten human health, animals, and the environment. Fix sources including (power plants, industries, homes) and mobile sources include (cars and motorcycles) are the main sources production and emission of HM. It is important to understand the main information about sources of emission, chemical processes (reactions, oxidation, and leaching), and how they precipitate. The aim of this study was to evaluation an increased risk of leukemia due to exposure to HM. In this article narrative, the first literature search was performed with 580 articles according to different databases: Elsevier, PubMed, Web of science, Spring, and Google Scholar databases. 70 articles were included in the analysis process. Finally, 8 full-text articles were selected in this research. The search was restricted to English-language papers published between 2000 and 2021. In final stage literature, there is a notable health effect (carcinogenic) because of exposure to heavy metals. According to the results of this research natural procedures and human activities (industrial processes, car exhaust, and cigarette smoke) are the most important of ways that heavy metals can enter the natural cycle. Air, food, soil, water, and groundwater are the main sources of heavy metals that can cause severe disorders in the human body. After entering the body through ingestion heavy metals produce stable bio-toxic compounds. These compounds by disrupting biological processes, interrupt the body’s functions and cause various cancers in the human body. The results of this study can help to politicians for make comprehensive decisions to solve the problem and increase public awareness of the use of protective equipment.


Corresponding author: Parisa Asban, Student of Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Phone: +989372152538, E-mail: ; Mohammad Javad Mohammadi, Department of Environmental Health Engineering, School of Public Health and Environmental Technologies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; and Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, E-mail:

Acknowledgments

The authors are grateful to Ahvaz Jundishapur University of Medical Sciences for providing necessary facilities to perform this research.

  1. Research funding: This work wasn’t financially supported.

  2. Author contributions: MH-L, AA, IP, AT-J, M-JM, A-MB-A, SZ, FK, HA-K, and PA were principal investigators of the study and drafted the manuscript. MH-L, M-JM, and PA were advisors of the study. MH-L, AA, IP, AT-J, M-JM, A-MB-A, SZ, FK, HA-K, and PA performed the statistical analysis. All authors contributed to the design and data analysis and assisted in the preparation of the final version of the manuscript. All authors read and approved the final version of the manuscript.

  3. Competing interests: The authors declare that they have no competing interests.

  4. Informed consent: Not applicable.

  5. Ethical approval: The conducted research is not related to either human or animal use.

  6. Disclosure statement: No potential conflict of interest was reported by the authors.

  7. Consent to participate: ‘Not applicable’ for that specific section.

References

1. Dobaradaran, S, Soleimani, F, Nabipour, I, Saeedi, R, Mohammadi, MJ. Heavy metal levels of ballast waters in commercial ships entering Busher port along the Persian Gulf. Mar Pollut Bull 2018;126:74–6. https://doi.org/10.1016/j.marpolbul.2017.10.094.Search in Google Scholar PubMed

2. Javvaji, V, Latesh, KV, Mounika, K, Musala, S. Implementation of water consumption and contamination detection system using arduino. Int J Commun Comput Technol 2021;10:11.10.31838/ijccts/10.02.03Search in Google Scholar

3. Goudarzi, G, Alavi, N, Geravandi, S, Idani, E, Behrooz, HRA, Babaei, AA, et al.. Health risk assessment on human exposed to heavy metals in the ambient air PM 10 in Ahvaz, southwest Iran. Int J Biometeorol 2018;62:1075–83. https://doi.org/10.1007/s00484-018-1510-x.Search in Google Scholar PubMed

4. Idani, E, Geravandi, S, Akhzari, M, Goudarzi, G, Alavi, N, Yari, AR, et al.. Characteristics, sources, and health risks of atmospheric PM10-bound heavy metals in a populated middle eastern city. Toxin Rev 2020;39:266–74. https://doi.org/10.1080/15569543.2018.1513034.Search in Google Scholar

5. Hu, W, Yu, Z, Gao, X, Wu, Y, Tang, M, Kong, L. Study on the damage of sperm induced by nickel nanoparticle exposure. Environ Geochem Health 2020;42:1715–24. https://doi.org/10.1007/s10653-019-00364-w.Search in Google Scholar PubMed

6. Kamarehei, B, Mirhosseini, SH, Jafari, A, Asgari, G, Bierjandi, M, Rostami, Z. Study of heavy metal concentration (As, Ba, Cd, Hg, Pb, Cr) in water resources and river of Borujerd city in 2008–2009. Sci Mag Yafte 2010;11:45–51.Search in Google Scholar

7. Valaei, N, Nazariha, M, Dehghanifard, E, Akbari, S. Concentration of heavy metals in drinking water sources of Karaj in 2017: a descriptive study. J Rafsanjan Univ Med Sci 2019;18:227–36.Search in Google Scholar

8. Fu, Z, Xi, S. The effects of heavy metals on human metabolism. Toxicol Mech Methods 2020;30:167–76. https://doi.org/10.1080/15376516.2019.1701594.Search in Google Scholar PubMed

9. Raj, K, Kaur, P, Gupta, G, Singh, S. Metals associated neurodegeneration in Parkinson’s disease: insight to physiological, pathological mechanisms and management. Neurosci Lett 2021;753:135873. https://doi.org/10.1016/j.neulet.2021.135873.Search in Google Scholar PubMed

10. Jermsittiparsert, K. Linkage between energy consumption, natural environment pollution, and public health dynamics in ASEAN. Int J Econ Finance Stud 2021;13:1–21.Search in Google Scholar

11. Taieban, SMR, Torabi, E, Najafpoor, AA, Alidadi, H, Zezoli, MA. Survey of biosorption chromium and cadmium from industrial effluent, by using agricultural waste material-a review article. Navid No 2012;16:1–14.Search in Google Scholar

12. Yang, F, Massey, IY. Exposure routes and health effects of heavy metals on children. Biometals 2019;32:563–73. https://doi.org/10.1007/s10534-019-00193-5.Search in Google Scholar PubMed

13. Mohamed, MF, Ahmed, NM, Fathy, YM, Abdelhamid, IA. Impact of heavy metals on oreochromis niloticus fish and using Electrophoresis as Bio-indicator for environmental pollution of Rosetta branch, River Nile, Egypt. Eur Chem Bull 2020;9:48–61. https://doi.org/10.17628/ecb.2020.9.48-61.Search in Google Scholar

14. Genc, S, Zadeoglulari, Z, Fuss, SH, Genc, K. The adverse effects of air pollution on the nervous system. J Toxicol 2012;2012:782462. https://doi.org/10.1155/2012/782462. 22523490.Search in Google Scholar PubMed PubMed Central

15. Kumar, A, Ali, M, Kumar, R, Kumar, M, Sagar, P, Pandey, RK, et al.. Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk. Sci Rep 2021;11:1–16. https://doi.org/10.1038/s41598-021-81579-9.Search in Google Scholar PubMed PubMed Central

16. Trasande, L, Landrigan, PJ, Schechter, C. Public health and economic consequences of methyl mercury toxicity to the developing brain. Environ Health Perspect 2005;113:590–6. https://doi.org/10.1289/ehp.7743.Search in Google Scholar PubMed PubMed Central

17. Ganguly, K, Levänen, B, Palmberg, L, Åkesson, A, Lindén, A. Cadmium in tobacco smokers: a neglected link to lung disease? Eur Respir Rev 2018;27:170122. https://doi.org/10.1183/16000617.0122-2017. 29592863.Search in Google Scholar PubMed PubMed Central

18. Rao, S, Anthony, ML, Chowdhury, N, Kathrotia, R, Mishra, M, Naithani, M, et al.. Molecular characterization of lung carcinomas: a study on diagnostic, predictive, and prognostic markers using immunohistochemical analysis at a Tertiary Care Center in Uttarakhand, India. J Carcinog 2021;20:17. https://doi.org/10.4103/jcar.jcar_14_21. 34729049.Search in Google Scholar PubMed PubMed Central

19. McKeage, MJ, Baguley, BC. Disrupting established tumor blood vessels: an emerging therapeutic strategy for cancer. Cancer 2010;116:1859–71. https://doi.org/10.1002/cncr.24975.Search in Google Scholar PubMed

20. Sardar, K, Ali, S, Hameed, S, Afzal, S, Fatima, S, Shakoor, MB, et al.. Heavy metals contamination and what are the impacts on living organisms. Greener J Environ Manag Publ Saf 2013;2:172–9. https://doi.org/10.15580/gjemps.2013.4.060413652.Search in Google Scholar

21. Pirooty, S, Ghasemzadeh, M. Toxic effects of Lead on different organs of the human body. Feyz J Kashan Univ Med Sci 2013;16:761–2.Search in Google Scholar

22. Mahurpawar, M. Effects of heavy metals on human health. Int J Res Granthaalayah 2015;530:1–7. https://doi.org/10.29121/granthaalayah.v3.i9se.2015.3282.Search in Google Scholar

23. Nachana’a Timothy, ETW. Environmental pollution by heavy metal: an overview. Chemistry 2019;3:72–82. https://doi.org/10.11648/j.ijec.20190302.14.Search in Google Scholar

24. Jaishankar, M, Tseten, T, Anbalagan, N, Mathew, BB, Beeregowda, KN. Toxicity, mechanism and health effects of some heavy metals. Interdiscipl Toxicol 2014;7:60–72. https://doi.org/10.2478/intox-2014-0009.Search in Google Scholar PubMed PubMed Central

25. Goudarzi, G, Alavi, N, Idani, E, Babaei, AA, Salmanzadeh, S, Mohammadi, MJ. Association of particulate maters attributed to outdoor air in Ahvaz, Iran during cold-warm season of 2017. Fresenius Environ Bull 2017;26:5428–33.Search in Google Scholar

26. Kabir, MH, Kormoker, T, Shammi, RS, Tusher, TR, Islam, MS, Khan, R, et al.. A comprehensive assessment of heavy metal contamination in road dusts along a hectic national highway of Bangladesh: spatial distribution, sources of contamination, ecological and human health risks. Toxin Rev 2021;41:860–79. https://doi.org/10.1080/15569543.2021.1952436.Search in Google Scholar

27. Soltani, N, Keshavarzi, B, Moore, F, Tavakol, T, Lahijanzadeh, AR, Jaafarzadeh, N, et al.. Ecological and human health hazards of heavy metals and polycyclic aromatic hydrocarbons (PAHs) in road dust of Isfahan metropolis, Iran. Sci Total Environ 2015;505:712–23. https://doi.org/10.1016/j.scitotenv.2014.09.097.Search in Google Scholar PubMed

28. Rafiee, M, Eslami, A, Saeedi, R, Abtahi, M, Jahangiri Rad, M. Multivariate and geostatistical analysis of spatial distribution and potential sources of heavy metals in surface waters. Casp J Environ Sci 2019;17:23–41.Search in Google Scholar

29. Pirrone, N, Cinnirella, S, Feng, X, Finkelman, RB, Friedli, HR, Leaner, J, et al.. Global mercury emissions to the atmosphere from anthropogenic and natural sources. Atmos Chem Phys 2010;10:5951–64. https://doi.org/10.5194/acp-10-5951-2010.Search in Google Scholar

30. Shahriyari, HA, Nikmanesh, Y, Jalali, S, Tahery, N, Zhiani Fard, A, Hatamzadeh, N, et al.. Air pollution and human health risks: mechanisms and clinical manifestations of cardiovascular and respiratory diseases. Toxin Rev 2022;41:606–17. https://doi.org/10.1080/15569543.2021.1887261.Search in Google Scholar

31. Organization, WHO. Air quality guidelines for Europe, 2nd ed. Copenhagen, Denmark: World Health Organization, European Series, Regional Office for Europe; 2000.Search in Google Scholar

32. Organization, WHO. Air quality guidelines: global update 2005: particulate matter, ozone, nitrogen dioxide, sulfur dioxide: global update 2005: summary of risk assessment. Geneva, Switzerland: World Health Organization; 2006:5–15 pp.Search in Google Scholar

33. Franklin, M, Schwartz, J. Differential effects of PM2. 5 Species on acute mortality. Epidemiology 2007;18:S175. https://doi.org/10.1097/01.ede.0000276874.31911.e4.Search in Google Scholar

34. Sharma, SB, Jain, S, Khirwadkar, P, Kulkarni, S. The effects of air pollution on the environment and human health. Indian J Res Pharm Biotechnol 2013;1:391–6.Search in Google Scholar

35. Demirbas, A. Potential applications of renewable energy sources, biomass combustion problems in boiler power systems and combustion related environmental issues. Prog Energy Combust Sci 2005;31:171–92. https://doi.org/10.1016/j.pecs.2005.02.002.Search in Google Scholar

36. Europe W. Health and Environment in Europe: progress assessment. Copenhagen: World Health Organization; 2010:50–62 pp.Search in Google Scholar

37. Xue, Y-H, Wu, J-H, Feng, Y-C, Dai, L, Bi, X-H, Li, X, et al.. Source characterization and apportionment of PM10 in Panzhihua, China. Aerosol Air Qual Res 2010;10:367–77. https://doi.org/10.4209/aaqr.2010.01.0002.Search in Google Scholar

38. Cheung, K, Daher, N, Kam, W, Shafer, MM, Ning, Z, Schauer, JJ, et al.. Spatial and temporal variation of chemical composition and mass closure of ambient coarse particulate matter (PM10–2.5) in the Los Angeles area. Atmos Environ 2011;45:2651–62. https://doi.org/10.1016/j.atmosenv.2011.02.066.Search in Google Scholar

39. Absalon, D, Ślesak, B. The effects of changes in cadmium and lead air pollution on cancer incidence in children. Sci Total Environ 2010;408:4420–8. https://doi.org/10.1016/j.scitotenv.2010.06.030.Search in Google Scholar PubMed

40. Cheng, S. Effects of heavy metals on plants and resistance mechanisms. Environ Sci Pollut Control Ser 2003;10:256–64. https://doi.org/10.1065/espr2002.11.141.2.Search in Google Scholar PubMed

41. Chelani, A, Gajghate, D, Hasan, M. Airborne toxic metals in air of Mumbai city, India. Bull Environ Contam Toxicol 2001;66:196–205. https://doi.org/10.1007/s0012800225.Search in Google Scholar PubMed

42. Ekpenyong, CE, Asuquo, AE. Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds. Int J Occup Med Environ Health 2017;30:1. https://doi.org/10.13075/ijomeh.1896.00800.Search in Google Scholar PubMed

43. Fairweather-Tait, SJ, Bao, Y, Broadley, MR, Collings, R, Ford, D, Hesketh, JE, et al.. Selenium in human health and disease. Antioxidants Redox Signal 2011;14:1337–83. https://doi.org/10.1089/ars.2010.3275.Search in Google Scholar PubMed

44. Abramson, N, Melton, B. Leukocytosis: basics of clinical assessment. Am Fam Physician 2000;62:2053–60.Search in Google Scholar

Received: 2022-11-17
Accepted: 2022-12-11
Published Online: 2022-12-29
Published in Print: 2024-06-25

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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