Home Medicine Ochratoxin A in coffee and coffee-based products: a global systematic review, meta-analysis, and probabilistic risk assessment
Article
Licensed
Unlicensed Requires Authentication

Ochratoxin A in coffee and coffee-based products: a global systematic review, meta-analysis, and probabilistic risk assessment

  • Yadolah Fakhri , Vahideh Mahdavi , Vahid Ranaei , Zahra Pilevar , Mansour Sarafraz , Trias Mahmudiono EMAIL logo and Amin Mousavi Khaneghah
Published/Copyright: November 14, 2022
Reviews on Environmental Health
From the journal Reviews on Environmental Health Volume 39 Issue 2

Abstract

Contamination of food with mycotoxins can pose harmful effects on the health of consumers in the long term. Coffee contamination with mycotoxins has become a global concern. This study attempted to meta-analyze the concentration and prevalence of ochratoxin A (OTA) in coffee products and estimate consumers’ health risks. The search was conducted among international databases, including Scopus, PubMed, Embase, and Web of Science, for 1 January 2010 to 1 May 2022. The concentration and prevalence of OTA in coffee products were meta-analyzed according to country subgroups. Health risk assessment was conducted based on Margin of Exposures (MOEs) using the Monte Carlo simulation (MCS) technique. The three countries that had the highest Pooled concentration of OTA in coffee were observed in Chile (100.00%), Kuwait (100.00%), and France (100.00%). The overall prevalence of OTA in coffee products was 58.01%, 95% CI (48.37–67.39). The three countries that had the highest concentration of OTA were Philippines (39.55 μg/kg) > Turkey (39.32 μg/kg) > and Panama (21.33 μg/kg). The mean of MOEs in the adult consumers in Panama (9,526) and the Philippines (8,873) was lower than 10,000, while the mean of MOEs in other countries was higher than 10,000. Therefore, monitoring and control plans should be carried out in different countries.

Keywords: coffee products; meta-analysis; Ochratoxin A; risk assessment
Corresponding author: Trias Mahmudiono, Department of Nutrition, Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia, E-mail:

Funding source: Hormozgan University of Medical Science

  1. Research funding: Hormozgan University of Medical Science.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: The conducted research is not related to either human or animal use.

References

1. Su, L, Shi, W, Chen, X, Meng, L, Yuan, L, Chen, X, et al.. Simultaneously and quantitatively analyze the heavy metals in Sargassum fusiforme by laser-induced breakdown spectroscopy. Food Chem 2021;338:127797. https://doi.org/10.1016/j.foodchem.2020.127797.Search in Google Scholar PubMed

2. Yu, C, Chen, X, Li, N, Zhang, Y, Li, S, Chen, J, et al.. Ag3PO4-based photocatalysts and their application in organic-polluted wastewater treatment. Environ Sci Pollut Res 2022;29:1–17. https://doi.org/10.1007/s11356-022-18591-7.Search in Google Scholar PubMed

3. Wang, Y, Wu, X, Liu, J, Zhai, Z, Yang, Z, Xia, J, et al.. Mo-modified band structure and enhanced photocatalytic properties of tin oxide quantum dots for visible-light driven degradation of antibiotic contaminants. J Environ Chem Eng 2022;10:107091. https://doi.org/10.1016/j.jece.2021.107091.Search in Google Scholar

4. Wang, M-R, Deng, L, Liu, G-C, Wen, L, Wang, J-G, Huang, K-B, et al.. Porous organic polymer-derived nanopalladium catalysts for chemoselective synthesis of antitumor benzofuro [2, 3-b] pyrazine from 2-bromophenol and isonitriles. Org Lett 2019;21:4929–32. https://doi.org/10.1021/acs.orglett.9b01230.Search in Google Scholar PubMed

5. Yang, Y, Zhu, H, Xu, X, Bao, L, Wang, Y, Lin, H, et al.. Construction of a novel lanthanum carbonate-grafted ZSM-5 zeolite for effective highly selective phosphate removal from wastewater. Microporous Mesoporous Mater 2021;324:111289. https://doi.org/10.1016/j.micromeso.2021.111289.Search in Google Scholar

6. Moondra, N, Jariwala, ND, Christian, RA. Microalgal-bacterial consortia: an alluring and novel approach for domestic wastewater treatment. WCM 2020;4:51–6. https://doi.org/10.26480/wcm.01.2020.51.56.Search in Google Scholar

7. Halim, KA, Yong, EL. Integrating two-stage up-flow anaerobic sludge blanket with a single-stage aerobic packed-bed reactorfor raw palm oil mill effluent treatment. Malays J Sustainable Agric 2018;2:15–8. https://doi.org/10.26480/mjsa.01.2018.15.18.Search in Google Scholar

8. Gebremeskel, AF, Ngoda, PN, Kamau-Mbuthia, EW, Mahungu, SM, Yildiz, F. Prevalence and controlling mechanisms of mycotoxin. Cogent Food Agric 2019;5:25–31. https://doi.org/10.1080/23311932.2019.1658978.Search in Google Scholar

9. Jafari, K, Fathabad, AE, Fakhri, Y, Shamsaei, M, Miri, M, Farahmandfar, R, et al.. Aflatoxin M1 in traditional and industrial pasteurized milk samples from Tiran County, Isfahan Province: a probabilistic health risk assessment. Ital J Food Sci 2021;33(1 Suppl):103–16. https://doi.org/10.15586/ijfs.v33isp1.2054.Search in Google Scholar

10. Mohsen, M, Hamid, T, Foroud, B, Fernandes, OCA, Humberto, CC, Mousavi, KA, et al.. Aflatoxin B1 in the Iranian pistachio nut and decontamination methods: a systematic review. Qual Assur Saf Crop Foods 2020;12:15–25. https://doi.org/10.15586/qas.v12i4.784.Search in Google Scholar

11. Gönenç, İM, Yilmaz Sezer, N, Yilmaz, S. Mycotoxin exposure and pregnancy. Crit Rev Toxicol 2020;50:594–604. https://doi.org/10.1080/10408444.2020.1803791.Search in Google Scholar PubMed

12. Sadeghi-Aliabadi, H, Zanjanchi, MA, Saghaie, L, Borzoei, M. Evaluation of the cytotoxic effect of hydroxypyridinone derivatives on HCT116 and SW480 colon cancer cell lines. Pharmaceut Chem J 2019;53:388–91. https://doi.org/10.1007/s11094-019-02010-2.Search in Google Scholar

13. Bangar, SP, Sharma, N, Bhardwaj, A, Phimolsiripol, Y. Lactic acid bacteria: a bio-green preservative against mycotoxins for food safety and shelf-life extension. Qual Assur Saf Crop Foods 2022;14:13–31. https://doi.org/10.15586/qas.v14i2.1014.Search in Google Scholar

14. De Souza, C, Khaneghah, AM, Oliveira, CAF. The occurrence of aflatoxin M1 in industrial and traditional fermented milk: a systematic review study. Ital J Food Sci 2021;33(1 Suppl):12–23. https://doi.org/10.15586/ijfs.v33isp1.1982.Search in Google Scholar

15. Heshmati, A, Khorshidi, M, Khaneghah, AM. The prevalence and risk assessment of aflatoxin in sesame based products. Ital J Food Sci 2021;33(1 Suppl):92–102. https://doi.org/10.15586/ijfs.v33isp1.2065.Search in Google Scholar

16. Pires, RC, Portinari, MR, Moraes, GZ, Khaneghah, AM, Gonçalves, BL, Rosim, RE, et al.. Evaluation of Anti-Aflatoxin M1 effects of heat-killed cells of Saccharomyces cerevisiae in Brazilian commercial yogurts. Qual Assur Saf Crop Foods 2022;14:75–81. https://doi.org/10.15586/qas.v14i1.1006.Search in Google Scholar

17. Ropejko, K, Twarużek, M. The occurrence of ochratoxin A in human body fluids – review. Toxin Rev 2019;40:347–60. https://doi.org/10.1080/15569543.2019.1605530.Search in Google Scholar

18. Aranega, JP, Oliveira, CA. Occurrence of mycotoxins in pastures: a systematic review. Qual Assur Saf Crop Foods 2022;14:135–44. https://doi.org/10.15586/qas.v14i3.1079.Search in Google Scholar

19. Cabañes, FJ, Bragulat, MR. Black aspergilli and ochratoxin A-producing species in foods. Curr Opin Food Sci 2018;23:1–10. https://doi.org/10.1016/j.cofs.2018.01.006.Search in Google Scholar

20. Bittner, A, Cramer, B, Harrer, H, Humpf, HU. Structure elucidation and in vitro cytotoxicity of ochratoxin alpha amide, a new degradation product of ochratoxin A. Mycotoxin Res 2015;31:83–90. https://doi.org/10.1007/s12550-014-0218-y.Search in Google Scholar PubMed

21. Nourbakhsh, F, Tajbakhsh, E. Neurotoxicity mechanism of ochratoxin A. Qual Assur Saf Crop Foods 2021;13:34–45. https://doi.org/10.15586/qas.v13i2.837.Search in Google Scholar

22. Bessaire, T, Perrin, I, Tarres, A, Bebius, A, Reding, F, Theurillat, V. Mycotoxins in green coffee: occurrence and risk assessment. Food Control 2019;96:59–67. https://doi.org/10.1016/j.foodcont.2018.08.033.Search in Google Scholar

23. Costa da Silva, M, de Castro, da Silva G, Barreto, J do N, Vitor de Oliveira Martins, P, Lopes da Silva, G, Ferreira da Silva, R, et al.. Ochratoxin A levels in fermented specialty coffees from Caparaó, Brazil: is it a cause of concern for coffee drinkers? Food Addit Contam 2021;38:1948–57. https://doi.org/10.1080/19440049.2021.1943542.Search in Google Scholar PubMed

24. Leitão, AL. Occurrence of ochratoxin A in coffee: threads and solutions—a mini-review. Beverages 2019;5:36. https://doi.org/10.3390/beverages5020036.Search in Google Scholar

25. Skarkova, J, Ostry, V, Malir, F, Roubal, T. Determination of ochratoxin A in food by high performance liquid chromatography. Anal Lett 2013;46:1495–504. https://doi.org/10.1080/00032719.2013.771266.Search in Google Scholar

26. Bittner, A, Cramer, B, Humpf, HU. Matrix binding of ochratoxin A during roasting. J Agric Food Chem 2013;61:12737–43. https://doi.org/10.1021/jf403984x.Search in Google Scholar PubMed

27. Helgilibrary. Egg consumption per capita in Jordan; 2021. Available from: https://www.helgilibrary.com/indicators/egg-consumption-per-capita/jordan/.Search in Google Scholar

28. EPA. Recommended use of body weight; 2015. 15–23 p. Available from: https://www.epa.gov/sites/production/files/2013-09/documents/recommended-use-of-bw34.pdf.Search in Google Scholar

29. EFSA. Risk assessment of ochratoxin A in food. EFSA J 2020;18:9–17. Available from: https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2020.6113.Search in Google Scholar

30. Heshmati, A, Mehri, F, Karami-Momtaz, J, Khaneghah, AM. The concentration and health risk of potentially toxic elements in black and green tea—both bagged and loose-leaf. Qual Assur Saf Crops Food 2020;12:140–50. https://doi.org/10.15586/qas.v12i3.761.Search in Google Scholar

31. Naimi, N, Pilevar, Z, Ranaei, V, Mahmudiono, T, Fakhri, Y, Paseban, A, et al.. The concentration of potentially toxic elements (PTEs) in apple fruit: a global systematic review, meta-analysis, and health risk assessment. Environ Sci Pollut Res 2022;21:1–12.10.1007/s11356-022-21158-1Search in Google Scholar PubMed

32. Mahdavi, V, Gordan, H, Peivasteh-Roudsari, L, Fakhri, Y. Carcinogenic and non-carcinogenic risk assessment induced by pesticide residues in commercially available ready-to-eat raisins of Iran based on Monte Carlo Simulation. Environ Res 2022;206:112253. https://doi.org/10.1016/j.envres.2021.112253.Search in Google Scholar PubMed

33. Atamaleki, A, Yazdanbakhsh, A, Gholizadeh, A, Naimi, N, Karimi, P, Thai, VN, et al.. Concentration of potentially harmful elements (PHEs) in eggplant vegetable (Solanum melongena) irrigated with wastewater: a systematic review and meta-analysis and probabilistic health risk assessment. Int J Environ Health Res 2022;32:1419–31. https://doi.org/10.1080/09603123.2021.1887461.Search in Google Scholar PubMed

34. Gao, L, Huang, X, Wang, P, Chen, Z, Hao, Q, Bai, S, et al.. Concentrations and health risk assessment of 24 residual heavy metals in Chinese mitten crab (Eriocheir sinensis). Qual Assur Saf Crop Foods 2022;14:82–91. https://doi.org/10.15586/qas.v14i1.1034.Search in Google Scholar

35. Bounar, A, Boukaka, K, Leghouchi, E. Determination of heavy metals in tomatoes cultivated under green houses and human health risk assessment. Qual Assur Saf Crop Foods 2020;12:76–86. https://doi.org/10.15586/qas2019.639.Search in Google Scholar

36. Rezaei, M, Malekirad, AA, Jabbari, M, Karimi-Dehkordi, M, Ghasemidehkordi, B, Teimoory, H, et al.. Essential elements in the different types of fruits, soil, and water samples collected from Markazi province, Iran: a health risk assessment study. Qual Assur Saf Crop Foods 2020;12:111–25. https://doi.org/10.15586/qas.v12i3.777.Search in Google Scholar

37. Foerster, C, Muñoz, K, Delgado-Rivera, L, Rivera, A, Cortés, S, Müller, A, et al.. Occurrence of relevant mycotoxins in food commodities consumed in Chile. Mycotoxin Res 2020;36:63–72. https://doi.org/10.1007/s12550-019-00369-5.Search in Google Scholar PubMed

38. Commission E. Commission Regulation (EC) No 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Off J Eur Union 2006;364:5–24.Search in Google Scholar

39. Regulation C. No 1126/2007 of 28 September 2007 amending Regulation (EC) No 1881/2006 setting maximum levels for certain contaminants in foodstuffs as regards. Search in, 2007.Search in Google Scholar

40. Nogueira, L, Foerster, C, Foerster, J, Egner, P, Koshiol, J, Ferreccio, C, et al.. Association of aflatoxin with gallbladder cancer in Chile. JAMA 2015;313:2075–7. https://doi.org/10.1001/jama.2015.4559.Search in Google Scholar PubMed PubMed Central

41. Munoz, K, Vega, M, Rios, G, Munoz, S, Madariaga, R. Preliminary study of ochratoxin A in human plasma in agricultural zones of Chile and its relation to food consumption. Food Chem Toxicol 2006;44:1884–9. https://doi.org/10.1016/j.fct.2006.06.008.Search in Google Scholar PubMed

42. Muñoz, K, Campos, V, Blaszkewicz, M, Vega, M, Alvarez, A, Neira, J, et al.. Exposure of neonates to ochratoxin A: first biomonitoring results in human milk (colostrum) from Chile. Mycotoxin Res 2010;26:59–67. https://doi.org/10.1007/s12550-009-0040-0.Search in Google Scholar PubMed

43. Muñoz, K, Campos, V, Blaszkewicz, M, Vega, M, Alvarez, A, Neira, J, et al.. Exposure of infants to ochratoxin A with breast milk. Arch Toxicol 2014;88:837–46.10.1007/s00204-013-1168-4Search in Google Scholar PubMed

44. Sedova, I, Kiseleva, M, Tutelyan, V. Mycotoxins in tea: occurrence, methods of determination and risk evaluation. Toxins 2018;10:444. https://doi.org/10.3390/toxins10110444.Search in Google Scholar PubMed PubMed Central

45. Dashti, B, AL-Hamli, S. Investigation of mycotoxins in selected food commodities in Kuwait: a case study. J Am Diet Assoc 2010;9:A92. https://doi.org/10.1016/j.jada.2010.06.343.Search in Google Scholar

46. Tozlovanu, M, Pfohl-Leszkowicz, A. Ochratoxin A in roasted coffee from French supermarkets and transfer in coffee beverages: comparison of analysis methods. Toxins 2010;2:1928–42. https://doi.org/10.3390/toxins2081928.Search in Google Scholar PubMed PubMed Central

47. Dembele, A, Coulibaly, A, Traoré, S, Mamadou, K, Silue, N, Abba, T, et al.. Détermination du niveau de contamination de l’ochratoxine A (OTA) dans les fèves de cacao à l’exportation. Tropicultura 2009;27:26–30.10.4314/ijbcs.v2i1.39721Search in Google Scholar

48. No R. 2006/EC (2006). Off J Eur Union L 1881;364:5–24.10.1038/024364a0Search in Google Scholar

49. Sueck, F, Hemp, V, Specht, J, Torres, O, Cramer, B, Humpf, H-U. Occurrence of the ochratoxin A degradation product 2′ R-ochratoxin A in coffee and other food: an update. Toxins 2019;11:329. https://doi.org/10.3390/toxins11060329.Search in Google Scholar PubMed PubMed Central

50. Sousa, T, Batista, L, Passamani, F, Lira, N, Cardoso, M, Santiago, W, et al.. Evaluation of the effects of temperature on processed coffee beans in the presence of fungi and ochratoxin A. J Food Saf 2019;39:e12584. https://doi.org/10.1111/jfs.12584.Search in Google Scholar

51. DePaula, J, Cunha, SC, Revi, I, Batista, AM, Sá, SV, Calado, V, et al.. Contents of key bioactive and detrimental compounds in health performance coffees compared to conventional types of coffees sold in the United States market. Food Funct 2020;11:7561–75. https://doi.org/10.1039/d0fo01674h.Search in Google Scholar PubMed

52. Khaneghah, AM, Fakhri, Y, Abdi, L, Coppa, CFSC, Franco, LT, de Oliveira, CAF. The concentration and prevalence of ochratoxin A in coffee and coffee-based products: a global systematic review, meta-analysis and meta-regression. Fungal Biol 2019;123:611–7. https://doi.org/10.1016/j.funbio.2019.05.012.Search in Google Scholar PubMed

53. Barcelo, JM, Barcelo, RC. Post-harvest practices linked with ochratoxin A contamination of coffee in three provinces of Cordillera Administrative Region, Philippines. Food Addit Contam 2018;35:328–40. https://doi.org/10.1080/19440049.2017.1393109.Search in Google Scholar PubMed

54. Aguilar-Alvarez, ME, Saucedo-Castañeda, G, Durand, N, Perraud-Gaime, I, González-Robles, RO, Rodríguez-Serrano, GM. The variety, roasting, processing, and type of cultivation determine the low OTA levels of commercialized coffee in Chiapas State, Mexico. Food Control 2021;126:108088. https://doi.org/10.1016/j.foodcont.2021.108088.Search in Google Scholar

55. Metin, R. Türk kahvesi örneklerinde okrataksin A varlığı. DergiParkh: Trakya Üniversitesi Fen Bilimleri Enstitüsü; 2006.Search in Google Scholar

56. Ergun, B, Soyseven, M, Işcan, G, Arli, G. Examination of ochratoxin-A content of coffees sold in local markets with high performance liquid chromatography. Eskisehir Tech Univ J Sci Technol C-Life Sci Biotechnol 2018;7:143–51.Search in Google Scholar

57. Kulahi, A, Kabak, B. A preliminary assessment of dietary exposure of ochratoxin A in Central Anatolia Region, Turkey. Mycotoxin Res 2020;36:327–37. https://doi.org/10.1007/s12550-020-00397-6.Search in Google Scholar PubMed

58. Brera, C, Caputi, R, Miraglia, M, Iavicoli, I, Salerno, A, Carelli, G. Exposure assessment to mycotoxins in workplaces: aflatoxins and ochratoxin A occurrence in airborne dusts and human sera. Microchem J 2002;73:167–73. https://doi.org/10.1016/s0026-265x(02)00061-9.Search in Google Scholar

59. Pakshir, K, Dehghani, A, Nouraei, H, Zareshahrabadi, Z, Zomorodian, K. Evaluation of fungal contamination and ochratoxin A detection in different types of coffee by HPLC-based method. J Clin Lab Anal 2021;35:e24001. https://doi.org/10.1002/jcla.24001.Search in Google Scholar PubMed PubMed Central

60. Gonçalves, A, Gkrillas, A, Dorne, J, Dall’Asta, C, Palumbo, R, Lima, N, et al.. Pre- and postharvest strategies to minimize mycotoxin contamination in the rice food chain. Compr Rev Food Sci Food Saf 2019;18:441–54. https://doi.org/10.1111/1541-4337.12420.Search in Google Scholar PubMed

61. Tilocca, B, Balmas, V, Hassan, ZU, Jaoua, S, Migheli, Q. A proteomic investigation of Aspergillus carbonarius exposed to yeast volatilome or to its major component 2-phenylethanol reveals major shifts in fungal metabolism. Int J Food Microbiol 2019;306:108265. https://doi.org/10.1016/j.ijfoodmicro.2019.108265.Search in Google Scholar PubMed

62. Ul Hassan, Z, Al Thani, R, Alnaimi, H, Migheli, Q, Jaoua, S. Investigation and application of Bacillus licheniformis volatile compounds for the biological control of toxigenic Aspergillus and Penicillium spp. ACS Omega 2019;4:17186–93. https://doi.org/10.1021/acsomega.9b01638.Search in Google Scholar PubMed PubMed Central

63. Saleh, AE, Ul-Hassan, Z, Zeidan, R, Al-Shamary, N, Al-Yafei, T, Alnaimi, H, et al.. Biocontrol activity of Bacillus megaterium BM344-1 against toxigenic fungi. ACS Omega 2021;6:10984–90. https://doi.org/10.1021/acsomega.1c00816.Search in Google Scholar PubMed PubMed Central

64. Benites, AJ, Fernandes, M, Boleto, AR, Azevedo, S, Silva, S, Leitão, AL. Occurrence of ochratoxin A in roasted coffee samples commercialized in Portugal. Food Control 2017;73:1223–8. https://doi.org/10.1016/j.foodcont.2016.10.037.Search in Google Scholar

65. Prajogo, U, Lutfi, M, Liana, Y, Adi, S. Evaluation of post-harvest coffee to conform with good manufacturing practices (GMP) to develop entrepreneurship. In: IOP conference series: earth and environmental science. IOP Publishing; 2020.10.1088/1755-1315/475/1/012046Search in Google Scholar

66. Etana, BOFMB, Aga, MC. Review on post-harvest and green bean coffee processing in Ethiopia. Sweetmarias 2019;31:66–73.Search in Google Scholar

67. Perez de Obanos, A, Gonzalez-Penas, E, Lopez de Cerain, A. Influence of roasting and brew preparation on the ochratoxin A content in coffee infusion. Food Addit Contam 2005;22:463–71. https://doi.org/10.1080/02652030500090042.Search in Google Scholar PubMed

68. Galarce-Bustos, O, Alvarado, M, Vega, M, Aranda, M. Occurrence of ochratoxin A in roasted and instant coffees in Chilean market. Food Control 2014;46:102–7. https://doi.org/10.1016/j.foodcont.2014.05.014.Search in Google Scholar

69. Ramalakshmi, K, Rao, KJM, Takano-Ishikawa, Y, Goto, M. Bioactivities of low-grade green coffee and spent coffee in different in vitro model systems. Food Chem 2009;115:79–85. https://doi.org/10.1016/j.foodchem.2008.11.063.Search in Google Scholar

70. TN, G, Velmourougane, K, Panneerselvam, P, Keshamma, E, Raghuramulu, Y. Occurrence of ochratoxin-A (OT-A) in green and commercial coffee samples. J Food Sci Technol 2007;44:247–9.Search in Google Scholar

71. Twarużek, M, Kosicki, R, Kwiatkowska-Giżyńska, J, Grajewski, J, Ałtyn, I. Ochratoxin A and citrinin in green coffee and dietary supplements with green coffee extract. Toxicon 2020;188:172–7. https://doi.org/10.1016/j.toxicon.2020.10.021.Search in Google Scholar PubMed

72. Jonatova, P, Dzuman, Z, Prusova, N, Hajslova, J, Stranska-Zachariasova, M. Occurrence of ochratoxin A and its stereoisomeric degradation product in various types of coffee available in the Czech market. World Mycotoxin J 2020;13:97–107. https://doi.org/10.3920/wmj2019.2507.Search in Google Scholar

73. Culliao, AGL, Barcelo, JM. Fungal and mycotoxin contamination of coffee beans in Benguet province, Philippines. Food Addit Contam 2015;32:250–60. https://doi.org/10.1080/19440049.2014.1001796.Search in Google Scholar PubMed

74. Oliveira, G, da Silva, DM, Pereira, RGFA, Paiva, LC, Prado, G, Batista, LR. Effect of different roasting levels and particle sizes on ochratoxin A concentration in coffee beans. Food Control 2013;34:651–6. https://doi.org/10.1016/j.foodcont.2013.06.014.Search in Google Scholar

75. Ferraz, MB, Farah, A, Iamanaka, BT, Perrone, D, Copetti, MV, Marques, VX, et al.. Kinetics of ochratoxin A destruction during coffee roasting. Food Control 2010;21:872–7. https://doi.org/10.1016/j.foodcont.2009.12.001.Search in Google Scholar

76. Castellanos-Onorio, O, Gonzalez-Rios, O, Guyot, B, Fontana, TA, Guiraud, J-P, Schorr-Galindo, S, et al.. Effect of two different roasting techniques on the ochratoxin A (OTA) reduction in coffee beans (Coffea arabica). Food Control 2011;22:1184–8. https://doi.org/10.1016/j.foodcont.2011.01.014.Search in Google Scholar

77. Preedy, VR. Coffee in health and disease prevention. Washington, D.C.: Academic Press; 2014.Search in Google Scholar

78. Romani, S, Pinnavaia, GG, Dalla Rosa, M. Influence of roasting levels on ochratoxin A content in coffee. J Agric Food Chem 2003;51:5168–71. https://doi.org/10.1021/jf030116p.Search in Google Scholar PubMed

79. Paterson, RRM, Lima, N. How will climate change affect mycotoxins in food? Food Res Int 2010;43:1902–14. https://doi.org/10.1016/j.foodres.2009.07.010.Search in Google Scholar

80. Fabiana, AC, Sara, CdS, Mnica, CPM, Daiani, MdS, Marcelo, nc. Diversity and association of filamentous fungi in coffee beans under organic and conventional cultivation. Afr J Microbiol Res 2014;8:2505–12. https://doi.org/10.5897/ajmr2013.6571.Search in Google Scholar

81. Chandler, D, Bending, G, Clarkson, J, Davidson, G, Hall, S, Mills, P, et al.. The consequences of the “cut off” criteria for pesticides: alternative methods of cultivation. Policy Common 2008;25:31–9.Search in Google Scholar

82. Taniwaki, M, Pitt, J, Teixeira, AA, Iamanaka, BT. The source of ochratoxin A in Brazilian coffee and its formation in relation to processing methods. Int J Food Microbiol 2003;82:173–9. https://doi.org/10.1016/s0168-1605(02)00310-0.Search in Google Scholar PubMed

83. Ouakhssase, A, Fatini, N, Ait Addi, E. A facile extraction method followed by UPLC-MS/MS for the analysis of aflatoxins and ochratoxin A in raw coffee beans. Food Addit Contam 2021;38:1551–60. https://doi.org/10.1080/19440049.2021.1925165.Search in Google Scholar PubMed

84. EFSA. Scientific opinion. EFSA J 2020;18:28–36. https://doi.org/10.2903/j.efsa.2020.6040. Available from: https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2020.6040 [Accessed 30 Jan 2020].Search in Google Scholar PubMed PubMed Central

Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/reveh-2022-0115).

Received: 2022-07-13
Accepted: 2022-10-27
Published Online: 2022-11-14
Published in Print: 2024-06-25

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. The lack of international and national health policies to protect persons with self-declared electromagnetic hypersensitivity
  4. The use of micronucleus assay in oral mucosa cells as a suitable biomarker in children exposed to environmental mutagens: theoretical concepts, guidelines and future directions
  5. Improving the purification of aqueous solutions by controlling the production of reactive oxygen species in non-thermal plasma; a systematic review
  6. Ochratoxin A in coffee and coffee-based products: a global systematic review, meta-analysis, and probabilistic risk assessment
  7. Green space in health research: an overview of common indicators of greenness
  8. The effects of fine particulate matter on the blood-testis barrier and its potential mechanisms
  9. Evaluation of chemicals leached from PET and recycled PET containers into beverages
  10. The association between bisphenol a exposure and attention deficit hyperactivity disorder in children: a meta-analysis of observational studies
  11. A review on arsenic pollution, toxicity, health risks, and management strategies using nanoremediation approaches
  12. The impact of air pollution and climate change on eye health: a global review
  13. Exposure to Polycyclic Aromatic Hydrocarbons and adverse reproductive outcomes in women: current status and future perspectives
  14. Mechanisms of cholera transmission via environment in India and Bangladesh: state of the science review
  15. Effects of sulfur dioxide inhalation on human health: a review
  16. Health effects of alkaline, oxygenated, and demineralized water compared to mineral water among healthy population: a systematic review
  17. Toxic effects due to exposure heavy metals and increased health risk assessment (leukemia)
  18. A systematic review on environmental perspectives of monkeypox virus
  19. How does formal and informal industry contribute to lead exposure? A narrative review from Vietnam, Uruguay, and Malaysia
  20. Letter to the Editor
  21. Comments on “Personal protective equipment (PPE) and plastic pollution during COVID-19: strategies for a sustainable environment”, by Fatima Ali Mazahir and Ali Mazahir Al Qamari
https://doi.org/10.1515/reveh-2022-0115
Keywords for this article
coffee products; meta-analysis; Ochratoxin A; risk assessment

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. The lack of international and national health policies to protect persons with self-declared electromagnetic hypersensitivity
  4. The use of micronucleus assay in oral mucosa cells as a suitable biomarker in children exposed to environmental mutagens: theoretical concepts, guidelines and future directions
  5. Improving the purification of aqueous solutions by controlling the production of reactive oxygen species in non-thermal plasma; a systematic review
  6. Ochratoxin A in coffee and coffee-based products: a global systematic review, meta-analysis, and probabilistic risk assessment
  7. Green space in health research: an overview of common indicators of greenness
  8. The effects of fine particulate matter on the blood-testis barrier and its potential mechanisms
  9. Evaluation of chemicals leached from PET and recycled PET containers into beverages
  10. The association between bisphenol a exposure and attention deficit hyperactivity disorder in children: a meta-analysis of observational studies
  11. A review on arsenic pollution, toxicity, health risks, and management strategies using nanoremediation approaches
  12. The impact of air pollution and climate change on eye health: a global review
  13. Exposure to Polycyclic Aromatic Hydrocarbons and adverse reproductive outcomes in women: current status and future perspectives
  14. Mechanisms of cholera transmission via environment in India and Bangladesh: state of the science review
  15. Effects of sulfur dioxide inhalation on human health: a review
  16. Health effects of alkaline, oxygenated, and demineralized water compared to mineral water among healthy population: a systematic review
  17. Toxic effects due to exposure heavy metals and increased health risk assessment (leukemia)
  18. A systematic review on environmental perspectives of monkeypox virus
  19. How does formal and informal industry contribute to lead exposure? A narrative review from Vietnam, Uruguay, and Malaysia
  20. Letter to the Editor
  21. Comments on “Personal protective equipment (PPE) and plastic pollution during COVID-19: strategies for a sustainable environment”, by Fatima Ali Mazahir and Ali Mazahir Al Qamari
Sign up now to receive a 20% welcome discount
Institutional Access
How does access work?
Have an idea on how to improve our website?
Please write us.
© 2025 De Gruyter Brill
Downloaded on 20.12.2025 from https://www.degruyterbrill.com/document/doi/10.1515/reveh-2022-0115/html
Scroll to top button