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Chelators and metal complex stability for radiopharmaceutical applications

  • Nkemakonam C. Okoye , Jakob E. Baumeister , Firouzeh Najafi Khosroshahi , Heather M. Hennkens EMAIL logo und Silvia S. Jurisson EMAIL logo
Veröffentlicht/Copyright: 20. Juli 2019
Radiochimica Acta
Aus der Zeitschrift Radiochimica Acta Band 107 Heft 9-11

Abstract

Diagnostic and therapeutic nuclear medicine relies heavily on radiometal nuclides. The most widely used and well-known radionuclide is technetium-99m (99mTc), which has dominated diagnostic nuclear medicine since the advent of the 99Mo/99mTc generator in the 1960s. Since that time, many more radiometals have been developed and incorporated into potential radiopharmaceuticals. One critical aspect of radiometal-containing radiopharmaceuticals is their stability under in vivo conditions. The chelator that is coordinated to the radiometal is a key factor in determining radiometal complex stability. The chelators that have shown the most promise and are under investigation in the development of diagnostic and therapeutic radiopharmaceuticals over the last 5 years are discussed in this review.

Keywords: Radiopharmaceutical; radiometal; bifunctional chelate; diagnostic imaging; radionuclide therapy; chelator

Acknowledgments

The authors acknowledge the University of Missouri Fellowship Program (J. E. Baumeister) in Radiochemistry supported by a grant to The Curators of the University of Missouri under award #NRC-HQ-15-G-0036, from the Office of the Chief Human Capital Officer of the Nuclear Regulatory Commission. Any statements, findings, conclusions, and recommendations are those of the author(s) and do not necessarily reflect the view of the Outreach and Recruitment Branch of the US Nuclear Regulatory Commission. The authors gratefully acknowledge support from the US Department of Energy, Office of Science, Isotope Research Program under grants DE-SC0018662 and DE-SC0018013 (F. Najafi Khosroshahi).

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Received: 2018-12-14
Accepted: 2019-06-25
Published Online: 2019-07-20
Published in Print: 2019-09-25

© 2019 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial: 150 years of the Periodic Table of Chemical Elements
  3. Part A: Actinides and Transactinides
  4. Evolution of the periodic table through the synthesis of new elements
  5. Nuclear and chemical characterization of heavy actinides
  6. Direct mass measurements and ionization potential measurements of the actinides
  7. Relativity in the electronic structure of the heaviest elements and its influence on periodicities in properties
  8. The periodic table – an experimenter’s guide to transactinide chemistry
  9. Synthesis and properties of isotopes of the transactinides
  10. Part B: Nuclear Energy
  11. Homogenous recycling of transuranium elements from irradiated fast reactor fuel by the EURO-GANEX solvent extraction process
  12. Separation of trivalent actinides and lanthanides using various ‘N’, ‘S’ and mixed ‘N,O’ donor ligands: a review
  13. Separation of actinides from lanthanides associated with spent nuclear fuel reprocessing in China: current status and future perspectives
  14. Contamination of Fukushima Daiichi Nuclear Power Station with actinide elements
  15. Protactinium(V) in aqueous solution: a light actinide without actinyl moiety
  16. What do we know about actinides-proteins interactions?
  17. Part C: Medical Radionuclides
  18. Positron-emitting radionuclides for applications, with special emphasis on their production methodologies for medical use
  19. Radiochlorine: an underutilized halogen tool
  20. Radiobromine and radioiodine for medical applications
  21. Radiochemical aspects of alpha emitting radionuclides for medical application
  22. Chelators and metal complex stability for radiopharmaceutical applications
https://doi.org/10.1515/ract-2018-3090
Schlagwörter für diesen Artikel
Radiopharmaceutical; radiometal; bifunctional chelate; diagnostic imaging; radionuclide therapy; chelator

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial: 150 years of the Periodic Table of Chemical Elements
  3. Part A: Actinides and Transactinides
  4. Evolution of the periodic table through the synthesis of new elements
  5. Nuclear and chemical characterization of heavy actinides
  6. Direct mass measurements and ionization potential measurements of the actinides
  7. Relativity in the electronic structure of the heaviest elements and its influence on periodicities in properties
  8. The periodic table – an experimenter’s guide to transactinide chemistry
  9. Synthesis and properties of isotopes of the transactinides
  10. Part B: Nuclear Energy
  11. Homogenous recycling of transuranium elements from irradiated fast reactor fuel by the EURO-GANEX solvent extraction process
  12. Separation of trivalent actinides and lanthanides using various ‘N’, ‘S’ and mixed ‘N,O’ donor ligands: a review
  13. Separation of actinides from lanthanides associated with spent nuclear fuel reprocessing in China: current status and future perspectives
  14. Contamination of Fukushima Daiichi Nuclear Power Station with actinide elements
  15. Protactinium(V) in aqueous solution: a light actinide without actinyl moiety
  16. What do we know about actinides-proteins interactions?
  17. Part C: Medical Radionuclides
  18. Positron-emitting radionuclides for applications, with special emphasis on their production methodologies for medical use
  19. Radiochlorine: an underutilized halogen tool
  20. Radiobromine and radioiodine for medical applications
  21. Radiochemical aspects of alpha emitting radionuclides for medical application
  22. Chelators and metal complex stability for radiopharmaceutical applications
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