Abstract
Cancer, one of the key health problems globally, is a group of related diseases that share a number of characteristics primarily the uncontrolled growth and invasive to surrounding tissues. Chemotherapy is one of the ways for the treatment of cancer which uses one or more anticancer agents as per chemotherapy regimen. Limitations of most anticancer drugs due to a variety of reasons such as serious side effects, drug resistance, lack of sensitivity and efficacy etc. generate the necessity towards the designing of novel anticancer lead molecules. In this regard, the synthesis of biologically active heterocyclic molecules is an appealing research area. Among heterocyclic compounds, nitrogen containing heterocyclic molecules has fascinated tremendous consideration due to broad range of pharmaceutical activity. Imidazoles, extensively present in natural products as well as synthetic molecules, have two nitrogen atoms, and are five membered heterocyclic rings. Because of their countless physiological and pharmacological characteristics, medicinal chemists are enthused to design and synthesize new imidazole derivatives with improved pharmacodynamic and pharmacokinetic properties. The aim of this present chapter is to discuss the synthesis, chemistry, pharmacological activity, and scope of imidazole-based molecules in anticancer drug development. Finally, we have discussed the current challenges and future perspectives of imidazole-based derivatives in anticancer drug development.
Acknowledgments
Authors are thankful to BHU and IIT Indore for research environment. N.K. acknowledges UGC, India for postdoctoral fellowship.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: N.G gratefully acknowledges the financial support from UGC, New Delhi (Letter No. F.30-431/2018(BSR), M-14-55) and IoE, BHU (Letter No. R/Dev/D/IoE/Seed Grant/2020-21).
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Reviews
- Recent endeavors in microbial remediation of micro- and nanoplastics
- Metal nanoparticles and its application on phenolic and heavy metal pollutants
- The story of nitrogen
- Recent development of imidazole derivatives as potential anticancer agents
- Indole based prostate cancer agents
- Lawsone (2-hydroxy-1,4-naphthaquinone) derived anticancer agents
- Small modular nuclear reactors are mostly bad policy
- A holistic environmental investigation of complementary energy in Alberta
- Green synthesis of various saturated S-heterocyclic scaffolds: an update
- Recent advances of heterocycle based anticancer hybrids
- Molecular docking and MD: mimicking the real biological process
- Synthesis of quinazolinone and quinazoline derivatives using green chemistry approach
- Nuclear fusion: the promise of endless energy
- Finance for Green Chemistry through Currency Mix
- Synthesis of bioactive scaffolds catalyzed by agro-waste-based solvent medium
- Recent developments in the green synthesis of biologically relevant cinnolines and phthalazines
- Detection of Rapid Eye Movement Behaviour Sleep Disorder using Time and Frequency Analysis of EEG Signal Applied on C4-A1 Channels
- Recent developments in C–C bond formation catalyzed by solid supported palladium: a greener perspective
- Visible-light-mediated metal-free C–Si bond formation reactions
- An overview of quinoxaline synthesis by green methods: recent reports
- Naturally occurring, natural product inspired and synthetic heterocyclic anti-cancer drugs
- Synthesis of bioactive natural products and their analogs at room temperature – an update
- One-pot multi-component synthesis of diverse bioactive heterocyclic scaffolds involving 6-aminouracil or its N-methyl derivatives as a versatile reagent
- Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development
- Triazine based chemical entities for anticancer activity
- Modification of kaolinite/muscovite clay for the removal of Pb(II) ions from aqueous media
- In silico design of ACE2 mutants for competitive binding of SARS-CoV-2 receptor binding domain with hACE2
- Computational study of Cu n AgAu (n = 1–4) clusters invoking DFT based descriptors
- Development of an online assessment system to evaluate knowledge on chemical safety and security
- Developing a questionnaire for diabetes mellitus type 2 risk effects and precondition factors – multivariate statistical paths
- Antioxidant and antibacterial activities of two xanthones derivatives isolated from the leaves extract of Anthocleista schweinfurthii Gilg (Loganiaceae)
- The stability increase of α-amylase enzyme from Aspergillus fumigatus using dimethyladipimidate
- Sustainability of ameliorative potentials of urea spiked poultry manure biochar types in simulated sodic soils
- Cytotoxicity test and antibacterial assay on the compound produced by the isolation and modification of artonin E from Artocarpus kemando Miq.
- Effects of alum, soda ash, and carbon dioxide on 40–50 year old concrete wastewater tanks
Artikel in diesem Heft
- Frontmatter
- Reviews
- Recent endeavors in microbial remediation of micro- and nanoplastics
- Metal nanoparticles and its application on phenolic and heavy metal pollutants
- The story of nitrogen
- Recent development of imidazole derivatives as potential anticancer agents
- Indole based prostate cancer agents
- Lawsone (2-hydroxy-1,4-naphthaquinone) derived anticancer agents
- Small modular nuclear reactors are mostly bad policy
- A holistic environmental investigation of complementary energy in Alberta
- Green synthesis of various saturated S-heterocyclic scaffolds: an update
- Recent advances of heterocycle based anticancer hybrids
- Molecular docking and MD: mimicking the real biological process
- Synthesis of quinazolinone and quinazoline derivatives using green chemistry approach
- Nuclear fusion: the promise of endless energy
- Finance for Green Chemistry through Currency Mix
- Synthesis of bioactive scaffolds catalyzed by agro-waste-based solvent medium
- Recent developments in the green synthesis of biologically relevant cinnolines and phthalazines
- Detection of Rapid Eye Movement Behaviour Sleep Disorder using Time and Frequency Analysis of EEG Signal Applied on C4-A1 Channels
- Recent developments in C–C bond formation catalyzed by solid supported palladium: a greener perspective
- Visible-light-mediated metal-free C–Si bond formation reactions
- An overview of quinoxaline synthesis by green methods: recent reports
- Naturally occurring, natural product inspired and synthetic heterocyclic anti-cancer drugs
- Synthesis of bioactive natural products and their analogs at room temperature – an update
- One-pot multi-component synthesis of diverse bioactive heterocyclic scaffolds involving 6-aminouracil or its N-methyl derivatives as a versatile reagent
- Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development
- Triazine based chemical entities for anticancer activity
- Modification of kaolinite/muscovite clay for the removal of Pb(II) ions from aqueous media
- In silico design of ACE2 mutants for competitive binding of SARS-CoV-2 receptor binding domain with hACE2
- Computational study of Cu n AgAu (n = 1–4) clusters invoking DFT based descriptors
- Development of an online assessment system to evaluate knowledge on chemical safety and security
- Developing a questionnaire for diabetes mellitus type 2 risk effects and precondition factors – multivariate statistical paths
- Antioxidant and antibacterial activities of two xanthones derivatives isolated from the leaves extract of Anthocleista schweinfurthii Gilg (Loganiaceae)
- The stability increase of α-amylase enzyme from Aspergillus fumigatus using dimethyladipimidate
- Sustainability of ameliorative potentials of urea spiked poultry manure biochar types in simulated sodic soils
- Cytotoxicity test and antibacterial assay on the compound produced by the isolation and modification of artonin E from Artocarpus kemando Miq.
- Effects of alum, soda ash, and carbon dioxide on 40–50 year old concrete wastewater tanks