Startseite Management of biofilm-associated infections in diabetic wounds – from bench to bedside
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Management of biofilm-associated infections in diabetic wounds – from bench to bedside

  • Subhasri Bogadi , Pooja Rao , Vasudha KU , Gowthamarajan Kuppusamy , SubbaRao V. Madhunapantula , Vetriselvan Subramaniyan , Veera Venkata Satyanarayana Reddy Karri EMAIL logo und Jamuna Bai Aswathanarayan EMAIL logo
Veröffentlicht/Copyright: 14. Mai 2024
Pure and Applied Chemistry
Aus der Zeitschrift Pure and Applied Chemistry Band 96 Heft 10

Abstract

Biofilms are complex bacterial colonies embedded in an extracellular matrix. These pose a major obstacle to wound healing and are noticeable in chronic wounds. It protects the bacteria from the host’s immune system and conventional antibiotic treatments. The biofilm’s protective matrix prevents essential nutrients and oxygen from diffusing into the surrounding healthy tissue. In addition, microbes living in biofilms naturally have increased resistance to antibiotics, which reduces the effectiveness of traditional therapies. As such, biofilms serve as persistent reservoirs of infection, which further disrupts the normal course of wound healing. In this review, the current formulation strategies such as hydrogels, polymeric nanoparticles, and nanofibers that are used in wound healing to counteract biofilms have been comprehensively discussed. The formulations have been meticulously designed and developed to disturb the biofilm matrix, prevent the growth of microorganisms, and increase the potency of antimicrobials and antibiotics. The mechanism of action, advantages and limitations associated with the existing formulation strategies have been reviewed. The formulation strategies that have been translated into clinical applications and patented are also discussed in this paper.

Keywords: Advanced wound care; antibiofilm; biofilm; formulation strategies; VCCA-2023; wound healing
Corresponding authors: Veera Venkata Satyanarayana Reddy Karri, Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, Tamil Nadu – 643001, India, e-mail: ; and Jamuna Bai Aswathanarayan, Department of Microbiology, JSS Academy of Higher Education & Research, Mysuru, Karnataka – 570015, India, e-mail:
Article note: A collection of invited papers based on presentations at the Virtual Conference on Chemistry and its Applications 2023.

Funding source: University Grants Commission

Acknowledgments

The authors would like to thank the UGC BSR Start-up Research Grant, Department of Science and Technology – Fund for Improvement of Science and Technology Infrastructure (DST-FIST), Promotion of University Research and Scientific Excellence (DST-PURSE), SIG In Biofilms in Clinical Settings & their Control, JSS AHER for the facilities provided for conducting the research.

  1. Research funding: The authors, Ms. Bogadi Subhasri, wish to express their gratitude to the Department of Science and Technology (DST-INSPIRE) Fellowship (ID IF200201) application reference no DST/INSPIRE/03/20 21/001920. New Delhi and technically approved by ICMR (Indian council of medical research) with Fellowship ID 2021–8531. The authors would like to acknowledge JSS AHER for the SIG grant – Biofilms in Clinical Settings & their Control and to UGC-BSR for Start-up Research Grant.

Abbreviations

PRRs

Pattern recognition receptors

PAMPs

Pathogen-associated molecular patterns

TLRs

Toll-like receptors

NLRs

NOD-like receptors

CLRs

C-type lectin receptors

ROS

Reactive oxygen species

ZnO

Zinc oxide

TiO2

Titanium dioxide

MgO

Magnesium oxide

GO

Graphene oxide

Cu

Copper

Ag

Silver

Fe3O4

Magnetite as catalysts

Fe2O3

Hematite as catalysts

SPIONs

Supra-paramagnetic iron oxide nanoparticles

EPS

Extracellular polymeric substances

PDT

Photodynamic therapy

UV

Ultraviolet irradiation

NPWT

Negative Pressure Wound Therapy

LLLT

Low-level laser therapy

LEDs

Low-intensity laser or light-emitting diodes

ATP

Adenosine triphosphate

HPWT

High-pressure wound therapy

Nrf2

Nuclear factor erythroid 2-related factor 2

MAPK

Mitogen-activated protein kinase

SOD

Superoxide dismutase

GSTs

Glutathione S-transferases

NAD(P)H:

Quinone oxidoreductase 1

TNF-alpha

Necrosis factor-alpha

FGF

Fibroblast growth factor

VEGF

Vascular endothelial growth factor

PDGF

Platelet-derived growth factor

TGF

Transforming growth factor-beta

IL-1

Interleukin-1

IL-6

Interleukin-6

ECM

Extracellular matrix

MMPs

Matrix metalloproteinases

QSIs

Quorum sensing inhibitors

QS

Quorum sensing

EDTA

Ethylenediaminetetraacetic acid

PEGs

Polyethene glycols

SLS

Sodium lauryl sulfate

SDS

Sodium dodecyl sulfate

BAC

Benzalkonium chloride

CAPB

Cocamidopropyl betaine

COOH

Carboxyl group

MRSA

Methicillin-resistant Staphylococcus aureus

disodium EDTA

Disodium-ethylene-diamine tetraacetate

NO

Nitric oxide

GAGs

Glycosaminoglycans

NAC

N-acetylcysteine

HBT

Hyperbaric oxygen therapy

BNC

Bacterial nanocellulose

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Published Online: 2024-05-14
Published in Print: 2024-10-28

© 2024 IUPAC & De Gruyter

Artikel in diesem Heft

  1. Frontmatter
  2. In this issue
  3. Special topic papers
  4. An innovative method using data acquisition and MATLAB for the electrochemical oxidation of formalin and the conversion of the oxidized products into a sound signal
  5. Evaluation of in vitro antioxidant activities, total phenolic and elemental contents of common herbs and spices (Moringa oleifera leaves, Allium sativum (Garlic) and Momordica charantia (ejinrin) leaves) in South-West Nigeria
  6. Management of biofilm-associated infections in diabetic wounds – from bench to bedside
  7. Biodegradation of naphthalene using Kocuria rosea isolated from a Sawmill in Ikenne, Southwestern Nigeria
  8. Production of green hydrogen through PEM water electrolysis
  9. Synthesis of potash alum from waste aluminum cans for the purification of river water
  10. Current advances in QuEChERS extraction of mycotoxins in various food and feed matrices
  11. Biological potentials of Landolphia owariensis leaf methanolic extract against pathogenic fungi isolates from different Dioscorea species
  12. Nitrogen leaching mitigation by tithonia biochar (Tithochar) in urea fertilizer treated sandy soil
  13. Phytochemicals as potential active principal components for formulation of alternative antifungal remedies against Trichophyton spp.: a systematic review
  14. A review on the green chemistry perspective of multipurpose use of cow urine
  15. Reactions of trans-[PtX2(pic)2] (Pic = γ-PICOLINE, X = Cl−, NO3 −) with N-acetyl-l-cysteine and glutathione
https://doi.org/10.1515/pac-2023-1117
Schlagwörter für diesen Artikel
Advanced wound care; antibiofilm; biofilm; formulation strategies; VCCA-2023; wound healing

Artikel in diesem Heft

  1. Frontmatter
  2. In this issue
  3. Special topic papers
  4. An innovative method using data acquisition and MATLAB for the electrochemical oxidation of formalin and the conversion of the oxidized products into a sound signal
  5. Evaluation of in vitro antioxidant activities, total phenolic and elemental contents of common herbs and spices (Moringa oleifera leaves, Allium sativum (Garlic) and Momordica charantia (ejinrin) leaves) in South-West Nigeria
  6. Management of biofilm-associated infections in diabetic wounds – from bench to bedside
  7. Biodegradation of naphthalene using Kocuria rosea isolated from a Sawmill in Ikenne, Southwestern Nigeria
  8. Production of green hydrogen through PEM water electrolysis
  9. Synthesis of potash alum from waste aluminum cans for the purification of river water
  10. Current advances in QuEChERS extraction of mycotoxins in various food and feed matrices
  11. Biological potentials of Landolphia owariensis leaf methanolic extract against pathogenic fungi isolates from different Dioscorea species
  12. Nitrogen leaching mitigation by tithonia biochar (Tithochar) in urea fertilizer treated sandy soil
  13. Phytochemicals as potential active principal components for formulation of alternative antifungal remedies against Trichophyton spp.: a systematic review
  14. A review on the green chemistry perspective of multipurpose use of cow urine
  15. Reactions of trans-[PtX2(pic)2] (Pic = γ-PICOLINE, X = Cl−, NO3 −) with N-acetyl-l-cysteine and glutathione
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