Mind from Matter? – Via Brain and Behavior
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Martin Heisenberg
Martin Heisenberg, born 1940 in Munich, studied Chemistry, Biochemistry and Genetics in Munich and Tübingen. As a postdoc he worked with Max Delbrück, California Institute of Technology, Pasadena (1966–1968), before he joined the group of Karl G. Götz at the Max-Planck-Institute of Biological Cybernetics, Tübingen to study brain and behavior of the fly
Drosophila melanogaster . He was one of the first to introduce Genetics as a tool in neuroethology. Since 1975 he is Professor at the University of Würzburg. His early studies of the fly visual system are summarized in a book “Vision in Drosophila” (1984; with R. Wolf). Other research foci are visual pattern recognition, the localization of memory traces, the role of initiating activity in operant behavior, perception, selective attention, and motivation. His goal is to establish a basic behavioral model of the brain.
Abstract
How did the process of Darwinian evolution lead from dead matter to the human mind? Of this long, complicated process the present essay selects and discusses just one step, that from animal behavior to animal mind. The process of living has two aspects, the maintenance of the process in the organism and the interaction of the organism with the world. In animals the latter is organized as behavior. Behavior evolves, as it serves the fitness of the animal. The brain evolves because it improves the behavior in terms of the animal’s fitness. Given the richness of the world and the openness of the future, the organization of behavior can be indirect and most intricate. The animal mind can be understood as behavioral organization at a higher level, as metaorganization. This concept is documented by behavioral studies in a particular animal, the fly Drosophila.
About the author
Martin Heisenberg, born 1940 in Munich, studied Chemistry, Biochemistry and Genetics in Munich and Tübingen. As a postdoc he worked with Max Delbrück, California Institute of Technology, Pasadena (1966–1968), before he joined the group of Karl G. Götz at the Max-Planck-Institute of Biological Cybernetics, Tübingen to study brain and behavior of the fly Drosophila melanogaster. He was one of the first to introduce Genetics as a tool in neuroethology. Since 1975 he is Professor at the University of Würzburg. His early studies of the fly visual system are summarized in a book “Vision in Drosophila” (1984; with R. Wolf). Other research foci are visual pattern recognition, the localization of memory traces, the role of initiating activity in operant behavior, perception, selective attention, and motivation. His goal is to establish a basic behavioral model of the brain.
References
Anderson, D. & Adolphs, A. (2014). A framework for studying emotions across species. Cell 157, 187–200. 10.1016/j.cell.2014.03.003Suche in Google Scholar PubMed PubMed Central
Batsching, S., Wolf, R. & Heisenberg, M. (2016). Inescapable Stress Changes Walking Behavior in Flies – Learned Helplessness Revisited. PLoS ONE 11(11):e0167066. doi:1371/journal.pone.0167066. 10.1371/journal.pone.0167066Suche in Google Scholar PubMed PubMed Central
Card, G. & Dickinson, M. H. (2008). Visually mediated motor planning in the scape response of Drosophila. CurrBiol 18, 1300–1307. Suche in Google Scholar
Chouhan, N. S., Wolf, R., Helfrich-Förster, C. & Heisenberg, M. (2015). Flies Remember the Time of Day. CurrBiol 25, 1619–1624. 10.1016/j.cub.2015.04.032Suche in Google Scholar PubMed
Delbrück, M. (1986). Mind from Matter? Blackwell Scientific Pub.Suche in Google Scholar
Gorostiza, A., Colomb, J. & Brembs, B. (2015). A value-based behavioural choice underlies phototaxis in Drosophila. doi: http://dx.doi.org./10.1101/023846.http://dx.doi.org./10.1101/023846Suche in Google Scholar
Heisenberg, M. (2015). Outcome learning, outcome expectations, and intentionality in Drosophila. LearnMem 22, 294–298.10.1101/lm.037481.114Suche in Google Scholar PubMed PubMed Central
Heisenberg, M. & Wolf, R. (1984). Vision in Drosophila. Springer, Berlin. 10.1007/978-3-642-69936-8Suche in Google Scholar
Holst, E. von, & Mittelstaedt, H. (1950). Das Reafferenzprinzip. Wechselwirkungen zwischen Zentralnervensystem und Peripherie. Naturwissenschaften 37, 464–476. 10.1007/BF00622503Suche in Google Scholar
Huber, R., Hill, S., Holladay, C., Biesiadecki, M., Tonioni, G.& Cirelli, C. (2004). Sleep Homeostasis in Drosophila melanogaster. Sleep 27, 628–639.10.1093/sleep/27.4.628Suche in Google Scholar PubMed
Kaun, K. A., Devineni, A. V. & Heberlein, U. (2012). Drosophila melanogaster as a model to study drug addiction. Hum Genet 131: 959–975. 10.1007/s00439-012-1146-6Suche in Google Scholar PubMed PubMed Central
Kelemann, K., Krüttner, S., Alenius, M. & Dickson, B. (2007). Function of the Drosophila CPEB protein Orb2 in long-term courtship memory. NatNeurosci 10, 1587–1593. 10.1038/nn1996Suche in Google Scholar PubMed
Koenig, S., Wolf, R. & Heisenberg, M. (2016). Visual Attention in Flies – Dopamine in the Mushroom Bodies Mediates the After-Effect of Cueing. PLoS ONE 11(8): e0161412. doi.10.1371/journal.pone.0161412.10.1371/journal.pone.0161412Suche in Google Scholar PubMed PubMed Central
Martin, J. R., Faure, P. & Ernst, R. (2001). The power-law distribution for walking-time intervals correlates with the ellipsoid-body in Drosophila. J. Neurogenet. 15, 205–219. 10.3109/01677060109167377Suche in Google Scholar PubMed
Pick, S. & Strauss, R. (2005). Goal-driven behavioral adaptations in gap-climbing Drosophila. CurrBiol 15, 1473–14878. 10.1016/j.cub.2005.07.022Suche in Google Scholar PubMed
Reichardt, W. & Wenking, H. (1969). Optical detection and fixation of objects by fixed flying flies. Naturwissenschaften 56: 424–425. 10.1007/BF00593644Suche in Google Scholar PubMed
Ries, A.-S., Hermanns, T. Poeck, B. & Strauss, R. (2017). Serotonin modulates a depression-like state in Drosophila responsive to lithium treatment. Nature Communications (8:15738) DOI: 10.1038/ncomms15738. 10.1038/ncomms15738Suche in Google Scholar PubMed PubMed Central
Sareen, P., Wolf, R. & Heisenberg, M, (2011). Attracting the Attention of a Fly. PNAS 108, 7230–7235. 10.1073/pnas.1102522108Suche in Google Scholar PubMed PubMed Central
Seugnet, L., Suzuki, Y., Vine, L.,Gottschalk, L. & Shaw, P. J. (2008). D1 receptor activation in the mushroom bodies rescues sleep-loss-induced learning impairments in Drosophila. Curr Biol 18, 1110–1117. 10.1016/j.cub.2008.07.028Suche in Google Scholar PubMed PubMed Central
Shohat-Ophir, G., Kaun, K. R., Azanachi, R. & Heberlein, U. (2012). Sexual deprivation increases ethanol intake in Drosophila. Science 335, 1351–1354.10.1126/science.1215932Suche in Google Scholar PubMed PubMed Central
Strausfeld, N. & Hirth, F. (2013). Deep homology of arthropod central complex and vertebrate basal ganglia. Science 340, 157–161. 10.1126/science.1231828Suche in Google Scholar PubMed
Su, C.-Y. & Wang, J. W. (2014). Modulation of neural circuits: how stimulus context shapes innate behavior in Drosophila. Current Op in Neurobiol. 29, 9–16. 10.1016/j.conb.2014.04.008Suche in Google Scholar PubMed PubMed Central
Toepfer, F., Wolf, R. & Heisenberg, M. (2018). Multi-stability with ambiguous visual stimuli in Drosophila orientation behavior. PLoS Biology 16(2): e2003113. https://doi.org/10.1371/journal.pbio.2003113.10.1371/journal.pbio.2003113Suche in Google Scholar PubMed PubMed Central
Ueda, A. & Wu, C.-F. (2009). Effects of social isolation on neuromuscular excitability and agressive behaviors in Drosophila: altered responses by Hk and gsts1, two mutations implicated in redox regulation. J Neurogenet. 23(4), 378–394. 10.3109/01677060903063026Suche in Google Scholar PubMed PubMed Central
Wolf, R. & Heisenberg, M. (1986). Visual orientation in Drosophila is an operant behavior. Nature 323, 154–156. 10.1038/323154a0Suche in Google Scholar
Wolf, R & Heisenberg, M. (1997). Visual space from visual motion: Turn integration in tethered flying Drosophila. Learning & Memory 4, 318–327. 10.1101/lm.4.4.318Suche in Google Scholar PubMed
Article note
German version available at https://doi.org/10.1515/nf-2018-0002
© 2018 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Übersichtsartikel
- Gedächtnismechanismen in Drosophila
- Making Memories. On the fly.
- Bewegungssehen: Zellen, Schaltkreise und Algorithmen
- Motion detection: cells, circuits and algorithms
- Molekulare Dynamik der neuronalen Informationsübertragung
- Molecular dynamics of neuronal information transfer
- Die Rolle von Histonmethylierungen in der Entwicklung des zentralen Nervensystems und bei Neuralrohrdefekten
- Histone methylations in the developing central nervous system and in neural tube defects
- „Mind from Matter?“ – Über Verhalten und Gehirn
- Mind from Matter? – Via Brain and Behavior
- Forschungsförderung
- Sonderforschungsbereich (SFB 1280) „Extinktionslernen“
- Kollaboratives Forschungszentrum (Sonderforschungsbereich, SFB) 1286 „Quantitative Synaptologie“
- Nachruf
- Nachruf auf Prof. Dr. Dr. h. c. mult. Franz Huber
- Nachruf auf Robert F. Schmidt
- Rezension
- Norman Doidge: Neustart im Kopf – Wie sich unser Gehirn selbst repariert
- Nachrichten
- Einladung zur Mitgliederversammlung während des FENS Forum 2018 in Berlin (7.–11. Juli 2018)
Artikel in diesem Heft
- Frontmatter
- Übersichtsartikel
- Gedächtnismechanismen in Drosophila
- Making Memories. On the fly.
- Bewegungssehen: Zellen, Schaltkreise und Algorithmen
- Motion detection: cells, circuits and algorithms
- Molekulare Dynamik der neuronalen Informationsübertragung
- Molecular dynamics of neuronal information transfer
- Die Rolle von Histonmethylierungen in der Entwicklung des zentralen Nervensystems und bei Neuralrohrdefekten
- Histone methylations in the developing central nervous system and in neural tube defects
- „Mind from Matter?“ – Über Verhalten und Gehirn
- Mind from Matter? – Via Brain and Behavior
- Forschungsförderung
- Sonderforschungsbereich (SFB 1280) „Extinktionslernen“
- Kollaboratives Forschungszentrum (Sonderforschungsbereich, SFB) 1286 „Quantitative Synaptologie“
- Nachruf
- Nachruf auf Prof. Dr. Dr. h. c. mult. Franz Huber
- Nachruf auf Robert F. Schmidt
- Rezension
- Norman Doidge: Neustart im Kopf – Wie sich unser Gehirn selbst repariert
- Nachrichten
- Einladung zur Mitgliederversammlung während des FENS Forum 2018 in Berlin (7.–11. Juli 2018)
