Correspondence on “COVID-19 vaccination and pregnancy”
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and
To the Editor,
We would like to share ideas on the publication “Covid-19 vaccination and pregnancy: a systematic review of maternal and neonatal outcomes [1]”. The effectiveness and safety of the Covid-19 immunization during pregnancy have been the subject of published observational studies, which Kontovazainitis et al. compiled in their summary [1]. The SARS Cov-2 immunization is safe and efficacious for pregnant women, according to Kontovazainitis et al. [1]. The findings are encouraging, but caution is advised due to some limitations, according to Kontovazainitis et al. [1]: only observational studies addressing this issue were found, and concurrently, the enrolled populations and the intervention (vaccination type and number of doses) were not homogeneous.
We both believe that the COVID-19 immunization may be beneficial for expectant mothers. As Kontovazainitis et al. pointed out, there is not yet enough information to draw a firm conclusion. In order to completely understand the findings, a variety of things must be taken into account. A distinctly negative reaction was one of the potential complicating elements that might have altered how the vaccine behaved. In a nutshell, a pregnant woman may experience concomitant medical issues including diabetes and anemia that could be caused by the body’s reaction to the immunization. It is impossible to draw a connection between asymptomatic COVID-19 and the lack of symptoms without specialist laboratory investigations. There may be a connection between asymptomatic COVID-19 and a lack of clinical symptoms in the absence of specialized laboratory investigations [2]. A silent COVID-19 must be ruled out if neither the recent clinical symptoms nor the current clinical signs are present. Different people’s immune systems appear to react to COVID-19 differently depending on inherited genetic variation [3].
The findings of the investigation need to be supported by additional clinical research. If additional research is conducted, it should include a thorough examination for the concurrent and prior-asymptomatic COVID-19, the exclusion of any cases involving concurrent medical issues (such as anemia and metabolic syndrome), and, if practical, a review of the genetic history.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors have no conflict of interest.
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Informed consent: Not applicable.
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Ethical approval: Not applicable.
References
1. Kontovazainitis, CG, Katsaras, GN, Gialamprinou, D, Mitsiakos, G. Covid-19 vaccination and pregnancy: a systematic review of maternal and neonatal outcomes. J Perinat Med 2023;51:823–39. https://doi.org/10.1515/jpm-2022-0463.Search in Google Scholar PubMed
2. Joob, B, Wiwanitkit, V. Letter to the editor: coronavirus disease 2019 (COVID-19), infectivity, and the incubation period. J Prev Med Public Health 2020;53:70.10.3961/jpmph.20.065Search in Google Scholar PubMed PubMed Central
3. Čiučiulkaitė, I, Möhlendick, B, Thümmler, L, Fisenkci, N, Elsner, C, Dittmer, U, et al.. GNB3 c.825c>T polymorphism influences T-cell but not antibody response following vaccination with the mRNA-1273 vaccine. Front Genet 2022;13:932043. https://doi.org/10.3389/fgene.2022.932043.Search in Google Scholar PubMed PubMed Central
© 2023 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Reviews
- Covid-19 vaccination and pregnancy: a systematic review of maternal and neonatal outcomes
- Improvised bubble continuous positive airway pressure ventilation use in neonates in resource-limited settings: a systematic review and meta-analysis
- Opinion Papers
- Anger: an underappreciated destructive force in healthcare
- Severe maternal thrombocytopenia and prenatal invasive procedures: still a grey zone
- Commentary
- The care of the magic of life before and after its beginning
- Original Articles – Obstetrics
- The impact of trimester of COVID-19 infection on pregnancy outcomes after recovery
- Adverse outcomes and maternal complications in pregnant women with severe-critical COVID-19: a tertiary center experience
- Are bacteria, fungi, and archaea present in the midtrimester amniotic fluid?
- Bioavailability of the tumor necrosis factor alpha/regulated on activation, normal T cell expressed and secreted (RANTES) biosystem inside the gestational sac during the pre-immune stages of embryo development
- The role of the soluble fms-like tyrosine kinase-1/placental growth factor (sFlt-1/PIGF) – ratio in clinical practice in obstetrics: diagnostic and prognostic value
- Prenatal diagnosis of non-mosaic sex chromosome abnormalities: a 10-year experience from a tertiary referral center
- Prediction of lung maturity through quantitative ultrasound analysis of fetal lung texture in women with diabetes during pregnancy
- Evaluation of an artificial intelligent algorithm (Heartassist™) to automatically assess the quality of second trimester cardiac views: a prospective study
- Original Article – Fetus
- Fetal brain activity and the free energy principle
- Predictive value of ultrasound in prenatal diagnosis of hypospadias: hints for accurate diagnosis
- The effect of maternal diabetes on the expression of gamma-aminobutyric acid and metabotropic glutamate receptors in male newborn rats’ inferior colliculi
- Original Articles – Neonates
- Respiratory function monitoring during early resuscitation and prediction of outcomes in prematurely born infants
- Quality improvement sustainability to decrease utilization drift for therapeutic hypothermia in the NICU
- Short Communication
- Use of a pocket-device point-of-care ultrasound to assess cervical dilation in labor: correlation and patient experience
- Letters to the Editor
- Correspondence on “COVID-19 vaccination and pregnancy”
- Response to the letter to the editor regarding “Covid-19 vaccination and pregnancy: a systematic review of maternal and neonatal outcomes”
Articles in the same Issue
- Frontmatter
- Reviews
- Covid-19 vaccination and pregnancy: a systematic review of maternal and neonatal outcomes
- Improvised bubble continuous positive airway pressure ventilation use in neonates in resource-limited settings: a systematic review and meta-analysis
- Opinion Papers
- Anger: an underappreciated destructive force in healthcare
- Severe maternal thrombocytopenia and prenatal invasive procedures: still a grey zone
- Commentary
- The care of the magic of life before and after its beginning
- Original Articles – Obstetrics
- The impact of trimester of COVID-19 infection on pregnancy outcomes after recovery
- Adverse outcomes and maternal complications in pregnant women with severe-critical COVID-19: a tertiary center experience
- Are bacteria, fungi, and archaea present in the midtrimester amniotic fluid?
- Bioavailability of the tumor necrosis factor alpha/regulated on activation, normal T cell expressed and secreted (RANTES) biosystem inside the gestational sac during the pre-immune stages of embryo development
- The role of the soluble fms-like tyrosine kinase-1/placental growth factor (sFlt-1/PIGF) – ratio in clinical practice in obstetrics: diagnostic and prognostic value
- Prenatal diagnosis of non-mosaic sex chromosome abnormalities: a 10-year experience from a tertiary referral center
- Prediction of lung maturity through quantitative ultrasound analysis of fetal lung texture in women with diabetes during pregnancy
- Evaluation of an artificial intelligent algorithm (Heartassist™) to automatically assess the quality of second trimester cardiac views: a prospective study
- Original Article – Fetus
- Fetal brain activity and the free energy principle
- Predictive value of ultrasound in prenatal diagnosis of hypospadias: hints for accurate diagnosis
- The effect of maternal diabetes on the expression of gamma-aminobutyric acid and metabotropic glutamate receptors in male newborn rats’ inferior colliculi
- Original Articles – Neonates
- Respiratory function monitoring during early resuscitation and prediction of outcomes in prematurely born infants
- Quality improvement sustainability to decrease utilization drift for therapeutic hypothermia in the NICU
- Short Communication
- Use of a pocket-device point-of-care ultrasound to assess cervical dilation in labor: correlation and patient experience
- Letters to the Editor
- Correspondence on “COVID-19 vaccination and pregnancy”
- Response to the letter to the editor regarding “Covid-19 vaccination and pregnancy: a systematic review of maternal and neonatal outcomes”
