Prediction of lung maturity through quantitative ultrasound analysis of fetal lung texture in women with diabetes during pregnancy
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Ana Carolina Rabachini Caetano
,
Luciano Marcondes Machado Nardozza
and
Rosiane Mattar
Abstract
Objectives
The present study aimed to evaluate the performance of QuantusFLM® software, which performs quantitative ultrasound analysis of fetal lung texture, in predicting lung maturity in fetuses of diabetic mothers.
Methods
The patients included in this study were between 34 and 38 weeks and 6 days gestation and were divided into two groups: (1) patients with diabetes on medication and (2) control. The ultrasound images were performed up to 48 h prior to delivery and analyzed using QuantusFLM® software, which classified each fetus as high or low risk for neonatal respiratory morbidity based on lung maturity or immaturity.
Results
A total of 111 patients were included in the study, being 55 in diabetes and 56 in control group. The pregnant women with diabetes had significantly higher body mass index (27.8 kg/m2 vs. 25.9 kg/m2, respectively, p=0.02), increased birth weight (3,135 g vs. 2,887 g, respectively, p=0.002), and a higher rate of labor induction (63.6 vs. 30.4 %, respectively, p<0.001) compared to the control group. QuantusFLM® software was able to predict lung maturity in diabetes group with 96.4 % accuracy, 96.4 % sensitivity and 100 % positive predictive value. Considering the total number of patients, the software demonstrated accuracy, sensitivity, specificity, positive predictive value and negative predictive value of 95.5 , 97.2, 33.3, 98.1 and 25 %, respectively.
Conclusions
QuantusFLM® was an accurate method for predicting lung maturity in normal and DM singleton pregnancies and has the potential to aid in deciding the timing of delivery for pregnant women with DM.
Funding source: Fundação de Amparo à Pesquisa do Estado de São Paulo
Award Identifier / Grant number: 2019/01298-0
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Research funding: This project was funded with the support of Fundação de Amparo à Pesquisa do Estado de São Paulo Foundation (FAPESP) number: 2019/01298-0 FAPESP funding was used to perform ultrasound analyzes of fetal lung texture using the QuantusFlm software®.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: Study approval statement: This study protocol was reviewed and approved by “Comitê de Ética em Pesquisa (CEP)” from Sao Paulo Federal University (UNIFESP), approval number 1341/2018.
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© 2023 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Reviews
- Covid-19 vaccination and pregnancy: a systematic review of maternal and neonatal outcomes
- Improvised bubble continuous positive airway pressure ventilation use in neonates in resource-limited settings: a systematic review and meta-analysis
- Opinion Papers
- Anger: an underappreciated destructive force in healthcare
- Severe maternal thrombocytopenia and prenatal invasive procedures: still a grey zone
- Commentary
- The care of the magic of life before and after its beginning
- Original Articles – Obstetrics
- The impact of trimester of COVID-19 infection on pregnancy outcomes after recovery
- Adverse outcomes and maternal complications in pregnant women with severe-critical COVID-19: a tertiary center experience
- Are bacteria, fungi, and archaea present in the midtrimester amniotic fluid?
- Bioavailability of the tumor necrosis factor alpha/regulated on activation, normal T cell expressed and secreted (RANTES) biosystem inside the gestational sac during the pre-immune stages of embryo development
- The role of the soluble fms-like tyrosine kinase-1/placental growth factor (sFlt-1/PIGF) – ratio in clinical practice in obstetrics: diagnostic and prognostic value
- Prenatal diagnosis of non-mosaic sex chromosome abnormalities: a 10-year experience from a tertiary referral center
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- Evaluation of an artificial intelligent algorithm (Heartassist™) to automatically assess the quality of second trimester cardiac views: a prospective study
- Original Article – Fetus
- Fetal brain activity and the free energy principle
- Predictive value of ultrasound in prenatal diagnosis of hypospadias: hints for accurate diagnosis
- The effect of maternal diabetes on the expression of gamma-aminobutyric acid and metabotropic glutamate receptors in male newborn rats’ inferior colliculi
- Original Articles – Neonates
- Respiratory function monitoring during early resuscitation and prediction of outcomes in prematurely born infants
- Quality improvement sustainability to decrease utilization drift for therapeutic hypothermia in the NICU
- Short Communication
- Use of a pocket-device point-of-care ultrasound to assess cervical dilation in labor: correlation and patient experience
- Letters to the Editor
- Correspondence on “COVID-19 vaccination and pregnancy”
- Response to the letter to the editor regarding “Covid-19 vaccination and pregnancy: a systematic review of maternal and neonatal outcomes”
Articles in the same Issue
- Frontmatter
- Reviews
- Covid-19 vaccination and pregnancy: a systematic review of maternal and neonatal outcomes
- Improvised bubble continuous positive airway pressure ventilation use in neonates in resource-limited settings: a systematic review and meta-analysis
- Opinion Papers
- Anger: an underappreciated destructive force in healthcare
- Severe maternal thrombocytopenia and prenatal invasive procedures: still a grey zone
- Commentary
- The care of the magic of life before and after its beginning
- Original Articles – Obstetrics
- The impact of trimester of COVID-19 infection on pregnancy outcomes after recovery
- Adverse outcomes and maternal complications in pregnant women with severe-critical COVID-19: a tertiary center experience
- Are bacteria, fungi, and archaea present in the midtrimester amniotic fluid?
- Bioavailability of the tumor necrosis factor alpha/regulated on activation, normal T cell expressed and secreted (RANTES) biosystem inside the gestational sac during the pre-immune stages of embryo development
- The role of the soluble fms-like tyrosine kinase-1/placental growth factor (sFlt-1/PIGF) – ratio in clinical practice in obstetrics: diagnostic and prognostic value
- Prenatal diagnosis of non-mosaic sex chromosome abnormalities: a 10-year experience from a tertiary referral center
- Prediction of lung maturity through quantitative ultrasound analysis of fetal lung texture in women with diabetes during pregnancy
- Evaluation of an artificial intelligent algorithm (Heartassist™) to automatically assess the quality of second trimester cardiac views: a prospective study
- Original Article – Fetus
- Fetal brain activity and the free energy principle
- Predictive value of ultrasound in prenatal diagnosis of hypospadias: hints for accurate diagnosis
- The effect of maternal diabetes on the expression of gamma-aminobutyric acid and metabotropic glutamate receptors in male newborn rats’ inferior colliculi
- Original Articles – Neonates
- Respiratory function monitoring during early resuscitation and prediction of outcomes in prematurely born infants
- Quality improvement sustainability to decrease utilization drift for therapeutic hypothermia in the NICU
- Short Communication
- Use of a pocket-device point-of-care ultrasound to assess cervical dilation in labor: correlation and patient experience
- Letters to the Editor
- Correspondence on “COVID-19 vaccination and pregnancy”
- Response to the letter to the editor regarding “Covid-19 vaccination and pregnancy: a systematic review of maternal and neonatal outcomes”
