Effect of antenatal betamethasone administration on Doppler velocimetry of fetal and uteroplacental vessels: a prospective study
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Atalay Ekin
, Cenk Gezer
Abstract
Objectives: To examine the effect of antenatal betamethasone administration on Doppler parameters of fetal and uteroplacental circulation.
Methods: Seventy-six singleton pregnancies that received betamethasone therapy were prospectively evaluated. Doppler measurements of pulsatility indices (PI) in fetal umbilical artery (UA), middle cerebral artery (MCA), ductus venosus and maternal uterine arteries were performed before (0 h) and 24, 48, 72 and 96 h after the first dose of betamethasone. Women with positive end-diastolic flow (EDF) in UA and those with absent or reversed EDF in UA were evaluated separately.
Results: Fifty-two women with EDF in UA and 24 women with absent or reversed flow in UA were examined. Administration of maternal betamethasone was followed by a significant decrease in the PI of the MCA at 24 h (P<0.05). Additionally, return of absent to positive, reversed to absent or from reversed to positive diastolic flow in UA was detected within 24 h in 19 (79.2%) fetuses with absent or reversed UA-EDF. All alterations were transient and maintained up to 72 h.
Conclusions: Antenatal administration of betamethasone is associated with significant but transient changes in the fetal blood flow. Hence, intensive surveillance of fetuses with Doppler ultrasonography is warranted following betamethasone therapy.
References
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The authors stated that there are no conflicts of interest regarding the publication of this article.
©2016 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Editorial
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- Recommendation and Guidelines for Perinatal Practice
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- Controversial ultrasound findings in mid trimester pregnancy. Evidence based approach
- Academy’s Corner
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- Effect of antenatal betamethasone administration on Doppler velocimetry of fetal and uteroplacental vessels: a prospective study
- Opinion paper
- Fetal cerebro-placental ratio and adverse perinatal outcome: systematic review and meta-analysis of the association and diagnostic performance
- Congress Calendar
- Congress Calendar
Artikel in diesem Heft
- Frontmatter
- Editorial
- Current topics on ultrasound in perinatology
- Recommendation and Guidelines for Perinatal Practice
- Ultrasound in Africa: what can really be done?
- 3D/4D sonography – any safety problem
- Controversial ultrasound findings in mid trimester pregnancy. Evidence based approach
- Academy’s Corner
- Sonoembryology by 3D HDlive silhouette ultrasound – what is added by the “see-through fashion”?
- Original articles – Obstetrics
- How effective is ultrasound-based screening for trisomy 18 without the addition of biochemistry at the time of late first trimester?
- Single center experience in selective feticide in high-order multiple pregnancy: clinical and ethical issues
- Diagnostic accuracy of cervical elastography in predicting labor induction success: a systematic review and meta-analysis
- Birth weight-related percentiles of brain ventricular system as a tool for assessment of posthemorrhagic hydrocephalus and ventricular enlargement
- First trimester erythropoietin (EPO) serum concentration as a potential marker for abnormal placentation disorders. Reference values for erythropoietin (EPO) concentration at 11–13+6 weeks of gestation
- Original articles – Fetus
- Nonimmune fetal ascites: identification of ultrasound findings predictive of perinatal death
- First trimester severe ductus venosus flow abnormalities in isolation or combination with other markers of aneuploidy and fetal anomalies
- Evaluation of the adequacy of reference charts for the accurate identification of fetuses with bone length below the 5th percentile
- Does ethnicity have an effect on fetal behavior? A comparison of Asian and Caucasian populations
- Accuracy of ultrasound in estimating fetal weight and growth discordancy in triplet pregnancies
- Fetal nasal bone length in the second trimester: comparison between population groups from different ethnic origins
- Pregnancy outcome and long-term follow-up of fetuses with isolated increased NT: a retrospective cohort study
- Effect of antenatal betamethasone administration on Doppler velocimetry of fetal and uteroplacental vessels: a prospective study
- Opinion paper
- Fetal cerebro-placental ratio and adverse perinatal outcome: systematic review and meta-analysis of the association and diagnostic performance
- Congress Calendar
- Congress Calendar