Startseite First trimester erythropoietin (EPO) serum concentration as a potential marker for abnormal placentation disorders. Reference values for erythropoietin (EPO) concentration at 11–13+6 weeks of gestation
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First trimester erythropoietin (EPO) serum concentration as a potential marker for abnormal placentation disorders. Reference values for erythropoietin (EPO) concentration at 11–13+6 weeks of gestation

  • Przemysław Kosiński EMAIL logo , Dorota A. Bomba-Opoń und Mirosław Wielgoś
Veröffentlicht/Copyright: 1. Mai 2015
Journal of Perinatal Medicine
Aus der Zeitschrift Journal of Perinatal Medicine Band 44 Heft 2

Abstract

Objectives: To investigate the possible effect of abnormal placentation disorders such as preeclampsia (PE), pregnancy induced hypertension (PIH) and intrauterine growth restriction (IUGR) on erythropoietin (EPO) serum concentration in women in the first trimester of pregnancy.

Material and methods: A prospective study was performed in a group of pregnant women between 11 and 13+6 weeks’ gestation. Serum concentration of EPO, beta HCG, PAPP-A and PlGF was measured. Mean arterial pressure (MAP) and uterine artery pulsatility index was calculated.

Results: A group of 198 analyzed patients was divided into three groups depending on pregnancy outcome: abnormal placentation group (n=30), macrosomia (n=13) and control group (n=155). EPO concentrations between the three groups of patients revealed that they differ significantly (F=15.172, P<0.001). EPO concentration is significantly higher in abnormal placentation patients compared to the control group (P<0.001) and macrosomia group (P=0.004). The most significant increase in EPO concentration was detected within patients with PIH. Also the uterine artery pulsatility index was positively correlated with EPO concentration (P<0.01).

Conclusions: First-trimester maternal EPO concentration might be considered as a possible marker of abnormal placentation disorders and should be given more attention in future prospective studies.

Keywords: Doppler studies; erythropoietin (EPO); placental growth factor; preeclampsia screening; uterine artery pulsatility index
Corresponding author: Przemysław Kosiński, First Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza 1/3, 02-015 Warsaw, Poland, Tel.: +48 22 583 03 01, Fax: +48 22 583 03 02, E-mail:

Acknowledgments

The study was supported by the Ministry of Science and Higher Education scientific grant number NN407115640.

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The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2015-2-25
Accepted: 2015-3-20
Published Online: 2015-5-1
Published in Print: 2016-3-1

©2016 by De Gruyter

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Current topics on ultrasound in perinatology
  4. Recommendation and Guidelines for Perinatal Practice
  5. Ultrasound in Africa: what can really be done?
  6. 3D/4D sonography – any safety problem
  7. Controversial ultrasound findings in mid trimester pregnancy. Evidence based approach
  8. Academy’s Corner
  9. Sonoembryology by 3D HDlive silhouette ultrasound – what is added by the “see-through fashion”?
  10. Original articles – Obstetrics
  11. How effective is ultrasound-based screening for trisomy 18 without the addition of biochemistry at the time of late first trimester?
  12. Single center experience in selective feticide in high-order multiple pregnancy: clinical and ethical issues
  13. Diagnostic accuracy of cervical elastography in predicting labor induction success: a systematic review and meta-analysis
  14. Birth weight-related percentiles of brain ventricular system as a tool for assessment of posthemorrhagic hydrocephalus and ventricular enlargement
  15. First trimester erythropoietin (EPO) serum concentration as a potential marker for abnormal placentation disorders. Reference values for erythropoietin (EPO) concentration at 11–13+6 weeks of gestation
  16. Original articles – Fetus
  17. Nonimmune fetal ascites: identification of ultrasound findings predictive of perinatal death
  18. First trimester severe ductus venosus flow abnormalities in isolation or combination with other markers of aneuploidy and fetal anomalies
  19. Evaluation of the adequacy of reference charts for the accurate identification of fetuses with bone length below the 5th percentile
  20. Does ethnicity have an effect on fetal behavior? A comparison of Asian and Caucasian populations
  21. Accuracy of ultrasound in estimating fetal weight and growth discordancy in triplet pregnancies
  22. Fetal nasal bone length in the second trimester: comparison between population groups from different ethnic origins
  23. Pregnancy outcome and long-term follow-up of fetuses with isolated increased NT: a retrospective cohort study
  24. Effect of antenatal betamethasone administration on Doppler velocimetry of fetal and uteroplacental vessels: a prospective study
  25. Opinion paper
  26. Fetal cerebro-placental ratio and adverse perinatal outcome: systematic review and meta-analysis of the association and diagnostic performance
  27. Congress Calendar
  28. Congress Calendar
https://doi.org/10.1515/jpm-2015-0079
Schlagwörter für diesen Artikel
Doppler studies; erythropoietin (EPO); placental growth factor; preeclampsia screening; uterine artery pulsatility index

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Current topics on ultrasound in perinatology
  4. Recommendation and Guidelines for Perinatal Practice
  5. Ultrasound in Africa: what can really be done?
  6. 3D/4D sonography – any safety problem
  7. Controversial ultrasound findings in mid trimester pregnancy. Evidence based approach
  8. Academy’s Corner
  9. Sonoembryology by 3D HDlive silhouette ultrasound – what is added by the “see-through fashion”?
  10. Original articles – Obstetrics
  11. How effective is ultrasound-based screening for trisomy 18 without the addition of biochemistry at the time of late first trimester?
  12. Single center experience in selective feticide in high-order multiple pregnancy: clinical and ethical issues
  13. Diagnostic accuracy of cervical elastography in predicting labor induction success: a systematic review and meta-analysis
  14. Birth weight-related percentiles of brain ventricular system as a tool for assessment of posthemorrhagic hydrocephalus and ventricular enlargement
  15. First trimester erythropoietin (EPO) serum concentration as a potential marker for abnormal placentation disorders. Reference values for erythropoietin (EPO) concentration at 11–13+6 weeks of gestation
  16. Original articles – Fetus
  17. Nonimmune fetal ascites: identification of ultrasound findings predictive of perinatal death
  18. First trimester severe ductus venosus flow abnormalities in isolation or combination with other markers of aneuploidy and fetal anomalies
  19. Evaluation of the adequacy of reference charts for the accurate identification of fetuses with bone length below the 5th percentile
  20. Does ethnicity have an effect on fetal behavior? A comparison of Asian and Caucasian populations
  21. Accuracy of ultrasound in estimating fetal weight and growth discordancy in triplet pregnancies
  22. Fetal nasal bone length in the second trimester: comparison between population groups from different ethnic origins
  23. Pregnancy outcome and long-term follow-up of fetuses with isolated increased NT: a retrospective cohort study
  24. Effect of antenatal betamethasone administration on Doppler velocimetry of fetal and uteroplacental vessels: a prospective study
  25. Opinion paper
  26. Fetal cerebro-placental ratio and adverse perinatal outcome: systematic review and meta-analysis of the association and diagnostic performance
  27. Congress Calendar
  28. Congress Calendar
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