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Children with isolated hypospadias have different hormonal profile compared to those with associated anomalies
-
Simmi K. Ratan
,
Satish Aggarwal
Veröffentlicht/Copyright:
20. Dezember 2011
Abstract
Aim: The objective of this study is to compare the hormonal profile of children with isolated hypospadias to controls and hypospadiacs with associated anomalies.
Materials and methods: Study design: Prospective observation at a tertiary referral hospital. Study subjects: One hundred consecutive children (0–12 years) with isolated hypospadias (H), 23 with hypospadias and associated anomalies (HO). Controls: One hundred children (0–12 years) without any genitourinary/endocrine abnormalities (C). Procedure: Pre-human chorionic gonadotropin (HCG) and post-HCG fasting blood samples were drawn for estimation of serum gonadotropins, dehydroepiandrosterone sulfate (DHEA-S), estrogen (E), progesterone (P), and testosterone (T) and dihydrotestosterone (DHT). Statistical analysis: Differences in hormonal levels between controls and subjects were computed with p≤0.05 as significant.
Results: Compared with controls, “H” had significantly higher follicular stimulating hormone (FSH) (1.37 vs. 1.29 mIU/mL p=0.01), lower estrogen (8.08 vs. 13.78 pg/mL, p=0.00), and lower DHEA-S (27.34 vs. 40.24 μg/dL, p=0.03) levels; HO had higher FSH, lower basal T (0.13 vs. 0.46 ng/mL, p=0.01), and lower peak testosterone (1.53 vs. 2.32 ng/mL, p=0.01). “HO” had lower androgens (basal T, 0.13 vs. 0.29 ng/mL, p=0.03; peak T, 1.53 vs. 2.36 ng/mL, p=0.01), and higher estrogen (12.56 vs. 8.08 pg/mL, p=0.001) and progesterone (0.46 vs. 0.31 ng/mL, p=0.04) levels in comparison with H.
Conclusion: Consistently lower output of androgens among HO explains the association of other anomalies (generally undescended testes) in them. High FSH among hypospadiacs hints at the possibility of Sertoli cell dysfunction and may have long-lasting sequelae for reproductive functions during adulthood. However, Leydig cell functions are affected more among HO.
Received: 2011-9-30
Accepted: 2011-11-15
Published Online: 2011-12-20
Published in Print: 2012-02-01
©2012 by Walter de Gruyter Berlin Boston
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- Reviews
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- Congenital hypothyroidism
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- Autoimmune thyroid disease and allergic contact dermatitis: two immune-related pathologies in the same patient
- Metformin use in children with obesity and normal glucose tolerance – effects on cardiovascular markers and intrahepatic fat
- The effects of metformin on inflammatory mediators in obese adolescents with insulin resistance: controlled randomized clinical trial
- Prevalence of components of the metabolic syndrome according to birthweight among overweight and obese children and adolescents
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- Effects of a multicomponent wellness intervention on dyslipidemia among overweight adolescents
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