Abstract
Objective: To assess the association between seroconversion and catch-up growth during the first year of a gluten-free diet (GFD) program in children with celiac disease (CD).
Methods: All prepubertal and biopsy-proven children diagnosed with CD between January 1999 and August 2009 were included in a retrospective study (n=55). Growth parameters and celiac antibodies were documented before and after 6 (period 1) and 12 months (period 2) of GFD, respectively.
Results: Mean height velocity-standard deviation score (SDS) was significantly higher in period 1 compared with that in period 2 (2.90±3.20 vs. 0.20±2.08, p<0.001) irrespective of the serology status, with marginal difference in mean weight-SDS gain (p=0.074). Mean levels of height velocity-SDS and the weight-SDS gain were similar in the seropositive and seronegative groups in both periods of the study. Mean height-SDS and weight-SDS levels after 6 months were higher than those in baseline levels, both in seropositive (–0.47±0.91 vs. –0.82±0.82, p<0.001 and –0.59±1.17 vs. –1.11±1.33, p<0.001, respectively) and seronegative patients (–1.02±1.14 vs. –1.50±1.12, p<0.001 and –1.19±1.27 vs. –1.45±1.40, p=0.048, respectively). These growth parameters were higher at the end compared with the beginning of period 2, but only in seropositive patients.
Conclusions: The most remarkable catch-up growth in children with CD can be expected during the first 6 months of GFD, irrespective of the serology status.
©2012 by Walter de Gruyter Berlin Boston
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- Meetings
- Meetings Calendar
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