Metformin use in children with obesity and normal glucose tolerance – effects on cardiovascular markers and intrahepatic fat
-
Nelly Mauras
, Charles DelGiorno
, Jobayer Hossain , Keisha Bird , Kelleigh Killen , Debbie Merinbaum , Arthur Weltman , Ligeia Damaso and Prabhakaran Balagopal
Abstract
Objective: To determine if metformin improves markers of inflammation, thrombosis, and intrahepatic fat contents in children with uncomplicated obesity.
Methods: Obese children with normal glucose tolerance but elevated highly sensitive C-reactive protein (hsCRP) and/or fibrinogen concentrations (>2 standard deviations) were randomized to structured diet/exercise or diet/exercise and metformin for 6 months. Blood samples, dual energy X-ray absorptiometry data, and liver magnetic resonance images were obtained.
Results: Forty-two of 66 recruited children (7–18 years) completed 6 months. Weight loss was modest but more pronounced in the metformin group (–4.9±1.0 kg) than in the diet/exercise group (–1.7±1.1 kg, p<0.03), whereas hsCRP and fibrinogen decreased more in the diet/exercise pubertal group. Baseline intrahepatic fat was high but decreased only in the diet/exercise (not metformin) pubertal group.
Conclusions: Six months of metformin therapy improved weight loss and reduced abdominal adiposity, but did not enhance the beneficial effect of diet and exercise on markers related to inflammation, thrombosis, or hepatic fat in obese children with normal glucose tolerance.
©2012 by Walter de Gruyter Berlin Boston
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- Meetings
- Meetings Calendar
- Prelims
- Prelims
Articles in the same Issue
- Editorial
- 10.1515/jpem-2012-0999
- Reviews
- Sertoli cell markers in the diagnosis of paediatric male hypogonadism
- Congenital hypothyroidism
- Images in Pediatric Endocrinology
- Autoimmune thyroid disease and allergic contact dermatitis: two immune-related pathologies in the same patient
- Metformin use in children with obesity and normal glucose tolerance – effects on cardiovascular markers and intrahepatic fat
- The effects of metformin on inflammatory mediators in obese adolescents with insulin resistance: controlled randomized clinical trial
- Prevalence of components of the metabolic syndrome according to birthweight among overweight and obese children and adolescents
- Association of early menarche age and overweight/obesity
- Serum chitotriosidase activity: is it a new inflammatory marker in obese children?
- Newer Doppler echocardiography techniques in assessment of heart function in obese patients
- Effects of a multicomponent wellness intervention on dyslipidemia among overweight adolescents
- The relation of vitamin D deficiency with puberty and insulin resistance in obese children and adolescents
- Ultrasonographic description of brain cortex and cingulate sulcus development in Mexican neonates and infants with congenital hypothyroidism
- GH deficiency during the transition period: clinical characteristics before and after GH replacement therapy in two different subgroups of patients
- Therapy strategies in vitamin D deficiency with or without rickets: efficiency of low-dose stoss therapy
- Children with isolated hypospadias have different hormonal profile compared to those with associated anomalies
- Duplication of SOX9 is not a common cause of 46,XX testicular or 46,XX ovotesticular DSD
- Evaluation of self-assessment of pubertal maturation in boys and girls using drawings and orchidometer
- Lack of association between seroconversion and catch-up growth in children with celiac disease
- Changes in carotid artery sonogram in premature adrenarche
- Patient Reports
- Delayed diagnosis of adrenal hypoplasia congenita in a patient with a new mutation in the NR0B1 gene
- Encephalopathy and sinustachycardia in childhood a possible differential diagnosis
- Difficult treatment of consumptive hypothyroidism in a child with massive parotid hemangioma
- Androgen receptor CAG and GGN polymorphisms in boys with isolated hypospadias
- Bilateral bloody nipple discharge in a male infant: sonographic findings and proposed diagnostic approach
- 49, XXXXY syndrome: an Italian child
- Intraoperative sonographic localization of a fractured Supprelin implant in a pediatric patient: a case report
- A girl with Hajdu-Cheney syndrome and premature ovarian failure
- A case of early-onset obesity, hypocortisolism, and skin pigmentation problem due to a novel homozygous mutation in the proopiomelanocortin (POMC) gene in an Indian boy
- Hepatic dysfunction is associated with vitamin D deficiency and poor glycemic control in diabetes mellitus
- Severe hypercalcemia without hypercalciuria in a previously healthy infant
- Mucolipidosis type II (I-cell disease) masquerading as rickets: two case reports and review of literature
- A case of diabetes mellitus associated with Rett Syndrome
- Peripubertal hypoglycemia – an unusual cause
- A pediatric Conn syndrome case
- Clinical and genetic characteristics and effects of long-term growth hormone therapy in a girl with Floating-Harbor syndrome
- Lack of mutations in the gene coding for the hGR (NR3C1) in a pediatric patient with ACTH-secreting pituitary adenoma, absence of stigmata of Cushing's syndrome and unusual histologic features
- Short Communication
- Known VDR polymorphisms are not associated with bone mineral density measures in pediatric Cushing disease
- Meetings
- Meetings Calendar
- Prelims
- Prelims