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Changes in carotid artery sonogram in premature adrenarche

  • Revi P. Mathew EMAIL logo , Marta Hernanz-Schulman , Wenli Wang , Benjamin Saville and Andrew Bremer
Published/Copyright: December 20, 2011

Abstract

Background: Premature adrenarche (PA), the appearance of pubic hair before the age of 8 years in girls and before 9 years in boys, may predict future morbidity, such as metabolic syndrome (MS).

Objective: The purpose of this study is to assess carotid artery ultrasound changes in children with PA.

Design/methods: PA children were matched with a group of prepubertal controls without PA. Subjects and controls underwent clinical and biochemical evaluation and sonograms of the carotid arteries.

Results: Twelve children with PA and their matched controls were studied. Carotid artery ultrasonography showed elevation of the inner and outer diameter of the left carotid, and the cross-sectional area of the lumen and outer wall, and the outer diameter of the right carotid artery in PA. However, none of the above results maintained statistical significance when a Hochberg correction was applied.

Conclusions: Carotid artery diameter and cross-sectional area may be useful non-invasive markers of vascular pathology and MS in premature pubarche.


Corresponding author: Revi P. Mathew, MD, FRCP, Division of Pediatric Endocrinology, Monroe Carell Jr. Children’s Hospital at Vanderbilt, 11136 DOT, 2200 Children’s Way, Nashville, TN 37232, USA Phone: +1 615 3227427, Fax: +1 615 3435845

Received: 2011-9-10
Accepted: 2011-11-15
Published Online: 2011-12-20
Published in Print: 2012-02-01

©2012 by Walter de Gruyter Berlin Boston

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