Startseite Automated insulin delivery in children with type 1 diabetes during physical activity: a meta-analysis
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Automated insulin delivery in children with type 1 diabetes during physical activity: a meta-analysis

  • Yuan-yuan Wang , Hui-min Ying , Fang Tian , Xiao-lu Qian , Zhen-feng Zhou und Chun-cong Zhou EMAIL logo
Veröffentlicht/Copyright: 3. Mai 2024
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 37 Heft 6

Abstract

Objectives

The aim of this study was to evaluate the performance of the automated insulin delivery (AID) in adolescents, and children with type 1 diabetes (T1D) during physical activity.

Methods

Relevant studies were searched electronically in the Cochrane Library, PubMed, and Embase utilizing the key words “Child”, “Insulin Infusion Systems”, and “Diabetes Mellitus” from inception to 17th March 2024 to evaluate the performance of the AID in adolescents, and children with T1D during physical activity.

Results

Twelve studies involving 514 patients were identified. AID did not show a beneficial effect on duration of hypoglycemia<70 mg/dL during study period (p>0.05; I2=96 %) and during the physical activity (p>0.99). Percentage of sensor glucose values in TIR was higher in AID than the non-AID pumps during study period (p<0.001; I2=94 %). The duration of hyperglycemic time was significantly decreased in AID group compared to the non-AID pumps group during study period (p<0.05; I2>50 %).

Conclusions

AID improved TIR and decreased the duration of hyperglycemic time, but did not appear to have a significant beneficial effect on the already low post-exercise duration of hypoglycemia achievable by open loop or sensor-augmented pumps in adolescents and children with T1D during physical activity; further research is needed to confirm the beneficial effect of AID on duration of hypoglycemia.

Keywords: child; type 1 diabetes; insulin infusion devices; physical activity
Corresponding author: Chun-cong Zhou, Department of Urolithiasis and Anorectal Surgery, Ningbo No. 2 Hospital, 41 Xibei Street, 315010, Ningbo, Zhejiang Province, P.R. China, Phone: +8657483870999, E-mail:

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: Yuan-yuan Wang and Chun-cong Zhou designed the study. Hui-min Ying, and Xiao-lu Qian did the work of data collecting, and data was analyzed by Fang Tian. Yuan-yuan Wang and Chun-cong Zhou wrote the paper. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Competing interests: The authors state no conflict of interest.

  5. Research funding: None declared.

  6. Data availability: All data analysed during this study were collected from published articles [Table 1].

  7. Trial registration: CRD42022367493; https://www.crd.york.ac.uk/PROSPERO, Principal investigator: Zhen-feng Zhou, Date of registration: October 30, 2022.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/jpem-2024-0098).

Received: 2024-02-24
Accepted: 2024-04-18
Published Online: 2024-05-03
Published in Print: 2024-06-25

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Original Articles
  3. Incidences of newly diagnosed childhood diabetes and onset severity: a multicenter regional study in Thailand over two decades and during the COVID-19 pandemic
  4. Exploring ketoacidosis frequency and risk factors in childhood-onset type 1 diabetes: an 8-year retrospective study (2011–2018) at a tertiary paediatric hospital in Tripoli, Libya
  5. Automated insulin delivery in children with type 1 diabetes during physical activity: a meta-analysis
  6. Association between maternal and cord blood thyroid hormones, and urine iodine concentration with fetal growth
  7. Post hoc subgroup analysis of Asian children with paediatric GHD from the global phase 3 efficacy and safety study of once-weekly somatrogon vs. once-daily somatropin
  8. Familial dysalbuminemic hyperthyroxinemia (FDH) due to Arg242 His variant in ALB gene in Turkish children
  9. A novel useful marker in the early discrimination of transient hyperthyrotropinemia/hypothyroxinemia and congenital hypothyroidism in preterm infants: thyroid-stimulating hormone/free thyroxine ratio
  10. Comprehensive analyses of phenylalanine hydroxylase variants and phenotypic characteristics of patients in the eastern region of Türkiye
  11. Relationship between urinary sodium excretion and bone mineral density in pediatrics: population-based study from KNHANES V 2010–2011
  12. Trajectory of the body mass index of children and adolescents attending a reference mental health center
  13. Case Reports
  14. Prenatal presentation of a hyperfunctioning thyroid nodule
  15. A very rare presentation of mitochondrial elongation factor Tu deficiency-TUFM mutation and literature review
  16. Identification of a novel homozygous NR5A1 variant in a patient with a 46,XY disorders of sex development
  17. Use of [18F]fluorocholine PET/CT in the detection of primary hyperparathyroidism in paediatrics: a case report
https://doi.org/10.1515/jpem-2024-0098
Schlagwörter für diesen Artikel
child; type 1 diabetes; insulin infusion devices; physical activity

Artikel in diesem Heft

  1. Frontmatter
  2. Original Articles
  3. Incidences of newly diagnosed childhood diabetes and onset severity: a multicenter regional study in Thailand over two decades and during the COVID-19 pandemic
  4. Exploring ketoacidosis frequency and risk factors in childhood-onset type 1 diabetes: an 8-year retrospective study (2011–2018) at a tertiary paediatric hospital in Tripoli, Libya
  5. Automated insulin delivery in children with type 1 diabetes during physical activity: a meta-analysis
  6. Association between maternal and cord blood thyroid hormones, and urine iodine concentration with fetal growth
  7. Post hoc subgroup analysis of Asian children with paediatric GHD from the global phase 3 efficacy and safety study of once-weekly somatrogon vs. once-daily somatropin
  8. Familial dysalbuminemic hyperthyroxinemia (FDH) due to Arg242 His variant in ALB gene in Turkish children
  9. A novel useful marker in the early discrimination of transient hyperthyrotropinemia/hypothyroxinemia and congenital hypothyroidism in preterm infants: thyroid-stimulating hormone/free thyroxine ratio
  10. Comprehensive analyses of phenylalanine hydroxylase variants and phenotypic characteristics of patients in the eastern region of Türkiye
  11. Relationship between urinary sodium excretion and bone mineral density in pediatrics: population-based study from KNHANES V 2010–2011
  12. Trajectory of the body mass index of children and adolescents attending a reference mental health center
  13. Case Reports
  14. Prenatal presentation of a hyperfunctioning thyroid nodule
  15. A very rare presentation of mitochondrial elongation factor Tu deficiency-TUFM mutation and literature review
  16. Identification of a novel homozygous NR5A1 variant in a patient with a 46,XY disorders of sex development
  17. Use of [18F]fluorocholine PET/CT in the detection of primary hyperparathyroidism in paediatrics: a case report
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