Prenatal presentation of a hyperfunctioning thyroid nodule
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Marinda G. Scrushy
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Christopher Liu
Abstract
Objectives
Fetal and neonatal hyperthyroidism are most commonly seen in patients whose mothers have Graves’ disease. Rarely, it can be caused by non-autoimmune conditions. As these conditions are rare, the workup and treatment is not uniform and can lead to persistent symptoms and long-term negative health effects.
Case presentation
This report describes a patient with congenital hyperthyroidism from a toxic adenoma presenting with fetal tachycardia. The patient was initially managed medically after birth, but was eventually treated with thyroidectomy.
Conclusions
This case report highlights an additional, important, differential diagnosis for fetal hyperthyroidism when maternal Graves’ disease has been ruled out.
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Research ethics: Not applicable.
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Informed consent: Informed consent was obtained.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no competing interests.
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Research funding: Funding played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
1. Leger, J, Carel, JC. Diagnosis and management of hyperthyroidism from prenatal life to adolescence. Best Pract Res Clin Endocrinol Metabol 2018;32:373–86. https://doi.org/10.1016/j.beem.2018.03.014.Search in Google Scholar PubMed
2. Namba, H, Ross, JL, Goodman, D, Fagin, JA. Solitary polyclonal autonomous thyroid nodule: a rare cause of childhood hyperthyroidism. J Clin Endocrinol Metab 1991;72:1108–12. https://doi.org/10.1210/jcem-72-5-1108.Search in Google Scholar PubMed
3. Samuels, SL, Namoc, SM, Bauer, AJ. Neonatal thyrotoxicosis. Clin Perinatol 2018;45:31–40. https://doi.org/10.1016/j.clp.2017.10.001.Search in Google Scholar PubMed
4. Kaplowitz, PB. Neonatal thyroid disease: testing and management. Pediatr Clin N Am 2019;66:343–52. https://doi.org/10.1016/j.pcl.2018.12.005.Search in Google Scholar PubMed
5. Segni, M. Neonatal hyperthyroidism. In: Feingold, KR, Anawalt, B, Boyce, A, Chrousos, G, Dungan, K, Grossman, A, et al.. editors. Endotext. South Dartmouth, MA: MDText.com, Inc; 2000.Search in Google Scholar
6. Polak, M. [Activating mutations of the TSH receptor: a synthesis highlighting certain pediatric aspects]. Arch Pediatr 1998;4:375s–9s. https://doi.org/10.1016/s0929-693x(99)80194-8.Search in Google Scholar PubMed
7. Stocco, E, Pelizzo, MR, Grassetto, G, Pagetta, C, Larizza, D, Massaro, A, et al.. Mini-invasive videoassisted thyroid lobectomy for neonatal hyperfunctioning adenoma related to a somatic TSHr gene mutation. Ann Endocrinol 2012;73:230–2. https://doi.org/10.1016/j.ando.2012.03.037.Search in Google Scholar PubMed
8. Kopp, P, Muirhead, S, Jourdain, N, Gu, WX, Jameson, JL, Rodd, C. Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation (serine281-->isoleucine) in the extracellular domain of the thyrotropin receptor. J Clin Invest 1997;100:1634–9. https://doi.org/10.1172/jci119687.Search in Google Scholar PubMed PubMed Central
9. Francis, GL, Waguespack, SG, Bauer, AJ, Angelos, P, Benvenga, S, Cerutti, JM, et al.. Management guidelines for children with thyroid nodules and differentiated thyroid cancer. Thyroid 2015;25:716–59. https://doi.org/10.1089/thy.2014.0460.Search in Google Scholar PubMed PubMed Central
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Articles in the same Issue
- Frontmatter
- Original Articles
- Incidences of newly diagnosed childhood diabetes and onset severity: a multicenter regional study in Thailand over two decades and during the COVID-19 pandemic
- Exploring ketoacidosis frequency and risk factors in childhood-onset type 1 diabetes: an 8-year retrospective study (2011–2018) at a tertiary paediatric hospital in Tripoli, Libya
- Automated insulin delivery in children with type 1 diabetes during physical activity: a meta-analysis
- Association between maternal and cord blood thyroid hormones, and urine iodine concentration with fetal growth
- Post hoc subgroup analysis of Asian children with paediatric GHD from the global phase 3 efficacy and safety study of once-weekly somatrogon vs. once-daily somatropin
- Familial dysalbuminemic hyperthyroxinemia (FDH) due to Arg242 His variant in ALB gene in Turkish children
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- Relationship between urinary sodium excretion and bone mineral density in pediatrics: population-based study from KNHANES V 2010–2011
- Trajectory of the body mass index of children and adolescents attending a reference mental health center
- Case Reports
- Prenatal presentation of a hyperfunctioning thyroid nodule
- A very rare presentation of mitochondrial elongation factor Tu deficiency-TUFM mutation and literature review
- Identification of a novel homozygous NR5A1 variant in a patient with a 46,XY disorders of sex development
- Use of [18F]fluorocholine PET/CT in the detection of primary hyperparathyroidism in paediatrics: a case report
Articles in the same Issue
- Frontmatter
- Original Articles
- Incidences of newly diagnosed childhood diabetes and onset severity: a multicenter regional study in Thailand over two decades and during the COVID-19 pandemic
- Exploring ketoacidosis frequency and risk factors in childhood-onset type 1 diabetes: an 8-year retrospective study (2011–2018) at a tertiary paediatric hospital in Tripoli, Libya
- Automated insulin delivery in children with type 1 diabetes during physical activity: a meta-analysis
- Association between maternal and cord blood thyroid hormones, and urine iodine concentration with fetal growth
- Post hoc subgroup analysis of Asian children with paediatric GHD from the global phase 3 efficacy and safety study of once-weekly somatrogon vs. once-daily somatropin
- Familial dysalbuminemic hyperthyroxinemia (FDH) due to Arg242 His variant in ALB gene in Turkish children
- A novel useful marker in the early discrimination of transient hyperthyrotropinemia/hypothyroxinemia and congenital hypothyroidism in preterm infants: thyroid-stimulating hormone/free thyroxine ratio
- Comprehensive analyses of phenylalanine hydroxylase variants and phenotypic characteristics of patients in the eastern region of Türkiye
- Relationship between urinary sodium excretion and bone mineral density in pediatrics: population-based study from KNHANES V 2010–2011
- Trajectory of the body mass index of children and adolescents attending a reference mental health center
- Case Reports
- Prenatal presentation of a hyperfunctioning thyroid nodule
- A very rare presentation of mitochondrial elongation factor Tu deficiency-TUFM mutation and literature review
- Identification of a novel homozygous NR5A1 variant in a patient with a 46,XY disorders of sex development
- Use of [18F]fluorocholine PET/CT in the detection of primary hyperparathyroidism in paediatrics: a case report
