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Trajectory of the body mass index of children and adolescents attending a reference mental health center

  • Juliana Echeveste-Navarrete , Patricia Zavaleta-Ramírez and Maria Fernanda Castilla-Peon ORCID logo EMAIL logo
Published/Copyright: April 19, 2024
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 37 Issue 6

Abstract

Objectives

The primary objective was to describe the standardized body mass index (z-BMI) trajectory of children and adolescents admitted to a psychiatric reference center in Mexico City according to their diagnosis and medication use. The secondary objective was to compare z-BMI between antipsychotic users and non-users.

Methods

This is a retrospective cohort study. The psychiatric diagnosis, prescribed medications, serial heights, and weights were collected from the medical records.

Results

The median baseline z-BMI of the 129 analyzed cases was 0.88 (interquartile range [IQR]: 0–1.92), and the prevalence of excessive weight (obesity or overweight) was 46.8 %. At the end of follow-up (median 50.3 weeks), the median change in z-BMI was −0.09 (IQR: −0.68 to 0.42). New long-term users of antipsychotics (n=29) had an increase in their z-BMI, in contrast to never-users (median difference 0.73, p=0.01) and to previous users (median difference 0.92, p=0.047). The 59 subjects with excessive weight at admission had a median z-BMI change of −0.39 (IQR: −0.81 to −0.04). Among patients with excessive weight and depression, there was a greater decrease in z-BMI in sertraline users (n=13) compared with fluoxetine users (n=15) (median −0.65 vs. 0.21, p<0.001).

Conclusions

New long-term users of antipsychotics showed a significant increase in their z-BMI. Patients with depressive disorders and obesity on sertraline therapy tended to show a decrease in their z-BMI.

Keywords: antipsychotic agents; body mass index; children; cohort studies; mental disorder; obesity
Corresponding author: Maria Fernanda Castilla-Peon, Pediatric Endocrinologist, Researcher at Hospital Psiquiátrico Infantil ‘Dr. Juan N. Navarro’, Comisión Nacional de Salud Mental y Adicciones, Av. San Fernando 86, Belisario Domínguez Secc 16, Tlalpan, 14080, Mexico City, México, E-mail:
Maria Fernanda Castilla-Peon and Patricia Zavaleta-Ramírez share senior authorship.

  1. Research ethics: The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The Ethics and Research Board of the Psychiatric Children Hospital’s “Dr. Juan N. Navarro” approved the study with the registration number OI1/02/1122 on February 18th, 2023.

  2. Informed consent: Not applicable.

  3. Author contributions: Juliana Echeveste-Navarrete collected data, Patricia Zavaleta-Ramírez contributed to the interpretation and writing of the manuscript, Maria Fernanda Castilla-Peon participated in the design, data analysis and writing. All the authors participated in drafting the work, and critical review. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Competing interests: The authors state no conflict of interest.

  5. Research funding: None declared.

  6. Data availability: The raw data can be obtained on request from the corresponding author.

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Received: 2024-01-19
Accepted: 2024-03-29
Published Online: 2024-04-19
Published in Print: 2024-06-25

© 2024 Walter de Gruyter GmbH, Berlin/Boston

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  12. Trajectory of the body mass index of children and adolescents attending a reference mental health center
  13. Case Reports
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  15. A very rare presentation of mitochondrial elongation factor Tu deficiency-TUFM mutation and literature review
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https://doi.org/10.1515/jpem-2024-0039
Keywords for this article
antipsychotic agents; body mass index; children; cohort studies; mental disorder; obesity

Articles in the same Issue

  1. Frontmatter
  2. Original Articles
  3. Incidences of newly diagnosed childhood diabetes and onset severity: a multicenter regional study in Thailand over two decades and during the COVID-19 pandemic
  4. Exploring ketoacidosis frequency and risk factors in childhood-onset type 1 diabetes: an 8-year retrospective study (2011–2018) at a tertiary paediatric hospital in Tripoli, Libya
  5. Automated insulin delivery in children with type 1 diabetes during physical activity: a meta-analysis
  6. Association between maternal and cord blood thyroid hormones, and urine iodine concentration with fetal growth
  7. Post hoc subgroup analysis of Asian children with paediatric GHD from the global phase 3 efficacy and safety study of once-weekly somatrogon vs. once-daily somatropin
  8. Familial dysalbuminemic hyperthyroxinemia (FDH) due to Arg242 His variant in ALB gene in Turkish children
  9. A novel useful marker in the early discrimination of transient hyperthyrotropinemia/hypothyroxinemia and congenital hypothyroidism in preterm infants: thyroid-stimulating hormone/free thyroxine ratio
  10. Comprehensive analyses of phenylalanine hydroxylase variants and phenotypic characteristics of patients in the eastern region of Türkiye
  11. Relationship between urinary sodium excretion and bone mineral density in pediatrics: population-based study from KNHANES V 2010–2011
  12. Trajectory of the body mass index of children and adolescents attending a reference mental health center
  13. Case Reports
  14. Prenatal presentation of a hyperfunctioning thyroid nodule
  15. A very rare presentation of mitochondrial elongation factor Tu deficiency-TUFM mutation and literature review
  16. Identification of a novel homozygous NR5A1 variant in a patient with a 46,XY disorders of sex development
  17. Use of [18F]fluorocholine PET/CT in the detection of primary hyperparathyroidism in paediatrics: a case report
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