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Abdominal aorta intima media thickness in obese children

  • Oya Yücel EMAIL logo , Halime Cevik , Sibel Tulgar Kinik , Kursad Tokel , Sibel Aka und Feyza Dinc
Veröffentlicht/Copyright: 10. Mai 2013
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 26 Heft 7-8

Abstract

The aim of this study is to investigate whether abdominal aorta intima media thickness (aIMT), increases in obese children and to determine risk factors. Ninety-six children aged 5–16 (51 obese and 45 non-obese) were enrolled in this prospective and cross-sectional study. Age, gender, and relative body mass index (BMI) were recorded. Their serum lipids, thyrotropin, fasting glucose and insulin levels were analyzed. The homeostasis model assessment (HOMA-IR) score was calculated for insulin resistance. Anthropometric and biochemical data were assessed along with aIMT. Findings in obese children were compared with those of non-obese control subjects. The aIMT was significantly greater in obese children. Similar trends were observed in both prepubertal children and adolescents. In obese children, the mean aIMT (mm) was 0.021 (years of age) +0.519. In non-obese children, the mean aIMT (mm) was 0.017 (years of age) +0.381. Our data suggests a relationship between glucose metabolism and aIMT in obese children. BMI was an independent risk factor for increasing aIMT. In conclusion, when compared with non-obese controls, obese children demonstrated significantly increased aIMT. Higher BMI, insulin, HOMA-IR and increased systolic blood pressure seem to be the main factors contributing to increased aIMT and risk for developing vascular disease. Childhood obesity contributes to the development of an increased aIMT.

Keywords: aorta intima media thickness; children; obesity
Corresponding author: Oya Yücel, Kosuyolu. Veysi Pasa Sok. 100.Yıl sitesi. H-Blok No:22, Usküdar, 34664 Istanbul, Turkey

Statistical analysis was made in a Professional bureau by Emire Bor.

Conflict of interest statement:

This study was supported by Baskent University Reasearch Foundation, Ankara, Turkey.

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Received: 2012-9-15
Accepted: 2013-4-1
Published Online: 2013-05-10
Published in Print: 2013-08-01

©2013 by Walter de Gruyter Berlin Boston

Artikel in diesem Heft

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  4. Editorial
  5. Precocious puberty and diagnostic tests
  6. Review article
  7. The influence of carbohydrate quality on cardiovascular disease, the metabolic syndrome, type 2 diabetes, and obesity – an overview
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  26. Abdominal aorta intima media thickness in obese children
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  31. Variable phenotype in five patients with Wolcott-Rallison syndrome due to the same EIF2AK3 (c.1259delA) mutation
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  41. Letters to the Editors
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https://doi.org/10.1515/jpem-2012-0297
Schlagwörter für diesen Artikel
aorta intima media thickness; children; obesity

Artikel in diesem Heft

  1. Masthead
  2. Masthead
  3. Editorials
  4. Editorial
  5. Precocious puberty and diagnostic tests
  6. Review article
  7. The influence of carbohydrate quality on cardiovascular disease, the metabolic syndrome, type 2 diabetes, and obesity – an overview
  8. Original Articles
  9. Triptorelin depot stimulation test for central precocious puberty
  10. Umbilical cord and fifth-day serum vaspin concentrations in small-, appropriate-, and large-for-gestational age neonates
  11. Growth patterns in pubertal HIV-infected adolescents and their correlation with cytokines, IGF-1, IGFBP-1, and IGFBP-3
  12. Estrogen receptor α gene analysis in girls with central precocious puberty
  13. Trends of body composition among adolescents according to maturation stage and body mass index
  14. Oxidized low-density lipoprotein levels and carotid intima-media thickness as markers of early atherosclerosis in prepubertal obese children
  15. Interaction of bone mineral density, adipokines and hormones in obese adolescents girls submitted in an interdisciplinary therapy
  16. The contribution of art therapy in poorly controlled youth with type 1 diabetes mellitus
  17. NOX, the main regulator in oxidative stress in experimental models of phenylketonuria?
  18. Changes in growth pattern, leptin ghrelin and neuropeptide Y levels after adenotonsillectomy in prepubertal children
  19. Impact of inborn errors of metabolism on admission in a neonatal intensive care unit: a 4-year report
  20. Correlation between bone mineral density measured by peripheral and central dual energy X-ray absorptiometry in healthy Indian children and adolescents aged 10–18 years
  21. Thyroid-stimulating hormone (TSH) level in nutritionally obese children and metabolic co-morbidity
  22. Hepatocyte growth factor as an indicator of neonatal maturity
  23. Pathophysiology of critical illness hyperglycemia in children
  24. The influence of exposure to maternal diabetes in utero on the rate of decline in β-cell function among youth with diabetes
  25. Clinical and molecular characterization of Chilean patients with Léri-Weill dyschondrosteosis
  26. Abdominal aorta intima media thickness in obese children
  27. Patient reports
  28. KCNJ11 in-frame 15-bp deletion leading to glibenclamide- responsive neonatal diabetes mellitus in a Chinese child
  29. Hoffmann’s syndrome and pituitary hyperplasia in an adolescent secondary to Hashimoto thyroiditis
  30. Late diagnosis of Cushing’s disease in a child: what lessons can be learned?1)
  31. Variable phenotype in five patients with Wolcott-Rallison syndrome due to the same EIF2AK3 (c.1259delA) mutation
  32. Recurrent infantile hypoglycemia due to combined fructose-1,6-diphosphatase deficiency and growth hormone deficiency
  33. A previously undescribed mutation detected by sequence analysis of CYP21A2 gene in an infant with salt wasting congenital adrenal hyperplasia
  34. Transient neonatal hyperparathyroidism: a presenting feature of sialidosis type II
  35. Effect of recombinant insulin-like growth factor-1 treatment on short-term linear growth in a child with Majewski osteodysplastic primordial dwarfism type II and hepatic insufficiency
  36. Duplication of dosage sensitive sex reversal area in a 46, XY patient with normal sex determining region of Y causing complete sex reversal
  37. The search for ectopic ACTH production in a 9-year-old boy
  38. Development of antibodies against growth hormone (GH) during rhGH therapy in a girl with idiopathic GH deficiency: a case report
  39. Ovotesticular disorder of sexual development and a rare 46,XX/47,XXY karyotype
  40. Brachydactyly mental retardation syndrome in differential diagnosis of pseudopseudohypoparathyroidism
  41. Letters to the Editors
  42. How much truth is there in the association between endometriosis and atherosclerosis?
  43. Delayed cord clamping in plethoric term neonates of diabetic mothers: friend or foe?
  44. Meetings
  45. Meetings Calendar
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