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Thyroid-stimulating hormone (TSH) level in nutritionally obese children and metabolic co-morbidity

  • Cenk Aypak EMAIL logo , Özlem Türedi , Adnan Yüce and Süleyman Görpelioğlu
Published/Copyright: April 22, 2013
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 26 Issue 7-8

Abstract

Objective: In recent years, there has been increasing focus on thyroid function in pediatric obese patients. Our aims were to investigate whether there is an association between serum thyroid-stimulating hormone (TSH) within the normal range and body mass index (BMI), and to determine if TSH levels correlate with metabolic risk factors in children.

Methods: A retrospective cross-sectional analysis was carried out on 528 euthyroid, age- and sex-matched lean, overweight, or obese children. Anthropometric indices, blood pressure, fasting blood glucose, hepatic enzymes, lipid profiles, TSH, free triiodothyronine (fT3), and free thyroxine (fT4) were assessed from medical records and compared among groups. Subjects with known presence of diabetes, using medications altering blood pressure and glucose or lipid metabolism, with TSH levels >97.5 or <2.5 percentile, or with autoimmune thyroid disease were excluded.

Results: Hypertension, dyslipidemia, and elevated levels of hepatic enzymes were found to be more common in overweight and obese children (p<0.001), and those metabolic changes were significantly correlated with the increase in BMI (p<0.05). Serum concentrations of TSH and fT3 within the normal range were higher in overweight and obese children (p<0.01), and TSH was positively correlated with total cholesterol, triglycerides, and systolic blood pressure (p<0.05).

Conclusion: Our findings suggest that obese children have higher serum TSH and fT3 levels even within the normal range, and that an increase in TSH is associated with dyslipidemia and higher systolic blood pressure. It remains to be seen whether TSH might serve as a potential marker of metabolic risk factors in obese pediatric patients.

Keywords: children; dyslipidemia; hypertension; obesity; thyroid hormones; thyrotropin
Corresponding author: Cenk Aypak, MD, Department of Family Medicine, Diskapi Training and Research Hospital, Ankara 06110, Turkey, Phone: +903123186981-514, Fax: +903123170287

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Received: 2012-12-3
Accepted: 2013-3-5
Published Online: 2013-04-22
Published in Print: 2013-08-01

©2013 by Walter de Gruyter Berlin Boston

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Editorials
  4. Editorial
  5. Precocious puberty and diagnostic tests
  6. Review article
  7. The influence of carbohydrate quality on cardiovascular disease, the metabolic syndrome, type 2 diabetes, and obesity – an overview
  8. Original Articles
  9. Triptorelin depot stimulation test for central precocious puberty
  10. Umbilical cord and fifth-day serum vaspin concentrations in small-, appropriate-, and large-for-gestational age neonates
  11. Growth patterns in pubertal HIV-infected adolescents and their correlation with cytokines, IGF-1, IGFBP-1, and IGFBP-3
  12. Estrogen receptor α gene analysis in girls with central precocious puberty
  13. Trends of body composition among adolescents according to maturation stage and body mass index
  14. Oxidized low-density lipoprotein levels and carotid intima-media thickness as markers of early atherosclerosis in prepubertal obese children
  15. Interaction of bone mineral density, adipokines and hormones in obese adolescents girls submitted in an interdisciplinary therapy
  16. The contribution of art therapy in poorly controlled youth with type 1 diabetes mellitus
  17. NOX, the main regulator in oxidative stress in experimental models of phenylketonuria?
  18. Changes in growth pattern, leptin ghrelin and neuropeptide Y levels after adenotonsillectomy in prepubertal children
  19. Impact of inborn errors of metabolism on admission in a neonatal intensive care unit: a 4-year report
  20. Correlation between bone mineral density measured by peripheral and central dual energy X-ray absorptiometry in healthy Indian children and adolescents aged 10–18 years
  21. Thyroid-stimulating hormone (TSH) level in nutritionally obese children and metabolic co-morbidity
  22. Hepatocyte growth factor as an indicator of neonatal maturity
  23. Pathophysiology of critical illness hyperglycemia in children
  24. The influence of exposure to maternal diabetes in utero on the rate of decline in β-cell function among youth with diabetes
  25. Clinical and molecular characterization of Chilean patients with Léri-Weill dyschondrosteosis
  26. Abdominal aorta intima media thickness in obese children
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  28. KCNJ11 in-frame 15-bp deletion leading to glibenclamide- responsive neonatal diabetes mellitus in a Chinese child
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  30. Late diagnosis of Cushing’s disease in a child: what lessons can be learned?1)
  31. Variable phenotype in five patients with Wolcott-Rallison syndrome due to the same EIF2AK3 (c.1259delA) mutation
  32. Recurrent infantile hypoglycemia due to combined fructose-1,6-diphosphatase deficiency and growth hormone deficiency
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  35. Effect of recombinant insulin-like growth factor-1 treatment on short-term linear growth in a child with Majewski osteodysplastic primordial dwarfism type II and hepatic insufficiency
  36. Duplication of dosage sensitive sex reversal area in a 46, XY patient with normal sex determining region of Y causing complete sex reversal
  37. The search for ectopic ACTH production in a 9-year-old boy
  38. Development of antibodies against growth hormone (GH) during rhGH therapy in a girl with idiopathic GH deficiency: a case report
  39. Ovotesticular disorder of sexual development and a rare 46,XX/47,XXY karyotype
  40. Brachydactyly mental retardation syndrome in differential diagnosis of pseudopseudohypoparathyroidism
  41. Letters to the Editors
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  43. Delayed cord clamping in plethoric term neonates of diabetic mothers: friend or foe?
  44. Meetings
  45. Meetings Calendar
https://doi.org/10.1515/jpem-2012-0384
Keywords for this article
children; dyslipidemia; hypertension; obesity; thyroid hormones; thyrotropin

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Editorials
  4. Editorial
  5. Precocious puberty and diagnostic tests
  6. Review article
  7. The influence of carbohydrate quality on cardiovascular disease, the metabolic syndrome, type 2 diabetes, and obesity – an overview
  8. Original Articles
  9. Triptorelin depot stimulation test for central precocious puberty
  10. Umbilical cord and fifth-day serum vaspin concentrations in small-, appropriate-, and large-for-gestational age neonates
  11. Growth patterns in pubertal HIV-infected adolescents and their correlation with cytokines, IGF-1, IGFBP-1, and IGFBP-3
  12. Estrogen receptor α gene analysis in girls with central precocious puberty
  13. Trends of body composition among adolescents according to maturation stage and body mass index
  14. Oxidized low-density lipoprotein levels and carotid intima-media thickness as markers of early atherosclerosis in prepubertal obese children
  15. Interaction of bone mineral density, adipokines and hormones in obese adolescents girls submitted in an interdisciplinary therapy
  16. The contribution of art therapy in poorly controlled youth with type 1 diabetes mellitus
  17. NOX, the main regulator in oxidative stress in experimental models of phenylketonuria?
  18. Changes in growth pattern, leptin ghrelin and neuropeptide Y levels after adenotonsillectomy in prepubertal children
  19. Impact of inborn errors of metabolism on admission in a neonatal intensive care unit: a 4-year report
  20. Correlation between bone mineral density measured by peripheral and central dual energy X-ray absorptiometry in healthy Indian children and adolescents aged 10–18 years
  21. Thyroid-stimulating hormone (TSH) level in nutritionally obese children and metabolic co-morbidity
  22. Hepatocyte growth factor as an indicator of neonatal maturity
  23. Pathophysiology of critical illness hyperglycemia in children
  24. The influence of exposure to maternal diabetes in utero on the rate of decline in β-cell function among youth with diabetes
  25. Clinical and molecular characterization of Chilean patients with Léri-Weill dyschondrosteosis
  26. Abdominal aorta intima media thickness in obese children
  27. Patient reports
  28. KCNJ11 in-frame 15-bp deletion leading to glibenclamide- responsive neonatal diabetes mellitus in a Chinese child
  29. Hoffmann’s syndrome and pituitary hyperplasia in an adolescent secondary to Hashimoto thyroiditis
  30. Late diagnosis of Cushing’s disease in a child: what lessons can be learned?1)
  31. Variable phenotype in five patients with Wolcott-Rallison syndrome due to the same EIF2AK3 (c.1259delA) mutation
  32. Recurrent infantile hypoglycemia due to combined fructose-1,6-diphosphatase deficiency and growth hormone deficiency
  33. A previously undescribed mutation detected by sequence analysis of CYP21A2 gene in an infant with salt wasting congenital adrenal hyperplasia
  34. Transient neonatal hyperparathyroidism: a presenting feature of sialidosis type II
  35. Effect of recombinant insulin-like growth factor-1 treatment on short-term linear growth in a child with Majewski osteodysplastic primordial dwarfism type II and hepatic insufficiency
  36. Duplication of dosage sensitive sex reversal area in a 46, XY patient with normal sex determining region of Y causing complete sex reversal
  37. The search for ectopic ACTH production in a 9-year-old boy
  38. Development of antibodies against growth hormone (GH) during rhGH therapy in a girl with idiopathic GH deficiency: a case report
  39. Ovotesticular disorder of sexual development and a rare 46,XX/47,XXY karyotype
  40. Brachydactyly mental retardation syndrome in differential diagnosis of pseudopseudohypoparathyroidism
  41. Letters to the Editors
  42. How much truth is there in the association between endometriosis and atherosclerosis?
  43. Delayed cord clamping in plethoric term neonates of diabetic mothers: friend or foe?
  44. Meetings
  45. Meetings Calendar
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