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Changes in growth pattern, leptin ghrelin and neuropeptide Y levels after adenotonsillectomy in prepubertal children

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Published/Copyright: April 20, 2013
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 26 Issue 7-8

Abstract

Aim: The purpose of this prospective study was to evaluate whether surgical treatment of adenotonsillar hypertrophy has an effect on growth patterns and circulating concentrations of leptin, ghrelin and neuropeptide Y, which are all significant in energy balance.

Materials and methods: The study group consisted of 20 children who underwent tonsillectomy with or without adenoidectomy due to chronic adenotonsillar hypertrophy. The ages ranged from 4.3 to 9.2 years with normal weight. The healthy control subjects consisted of 30 age- and sex-matched children (control group) with ages between 3.2 and 8.1 years. Serum levels of leptin ghrelin and neuropeptide Y were measured in the preoperative period and at the end of the postoperative period, which was 6 months in the study group, serum levels were only measured during the first examination in the control group.

Results: When the study group (preoperative) is compared with the control group, it is observed that the leptin and ghrelin levels were higher in the study group and that the neuropeptide Y levels were similar (p=0.01, p=0.005, p=0.19, respectively). When the preoperative and postoperative anthropometric data were compared, it was observed that weight, height, body mass index (BMI) and BMI-standard deviation score (SDS) values increased in the 6th month postoperatively (p<0.001, p<0.001, p=0.01, p=0.03, respectively). However, the leptin, ghrelin and neuropeptide Y levels were similar (p=0.70, p=0.12, p=0.60, respectively).

Conclusion: Following adenotonsillectomy, an increase in weight and height occurred in the children. In the postoperative period, dietary and lifestyle suggestions as well as growth monitoring might be useful.

Keywords: adenotonsillectomy; children; ghrelin; leptin; noropeptide Y; obesity
Corresponding author: Nesibe Andiran, Department of Pediatric Endocrinology, Keçiören Training and Research Hospital, Ankara, Turkey

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Received: 2012-10-13
Accepted: 2013-2-18
Published Online: 2013-04-20
Published in Print: 2013-08-01

©2013 by Walter de Gruyter Berlin Boston

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  1. Masthead
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  3. Editorials
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  5. Precocious puberty and diagnostic tests
  6. Review article
  7. The influence of carbohydrate quality on cardiovascular disease, the metabolic syndrome, type 2 diabetes, and obesity – an overview
  8. Original Articles
  9. Triptorelin depot stimulation test for central precocious puberty
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  19. Impact of inborn errors of metabolism on admission in a neonatal intensive care unit: a 4-year report
  20. Correlation between bone mineral density measured by peripheral and central dual energy X-ray absorptiometry in healthy Indian children and adolescents aged 10–18 years
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https://doi.org/10.1515/jpem-2012-0325
Keywords for this article
adenotonsillectomy; children; ghrelin; leptin; noropeptide Y; obesity

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Editorials
  4. Editorial
  5. Precocious puberty and diagnostic tests
  6. Review article
  7. The influence of carbohydrate quality on cardiovascular disease, the metabolic syndrome, type 2 diabetes, and obesity – an overview
  8. Original Articles
  9. Triptorelin depot stimulation test for central precocious puberty
  10. Umbilical cord and fifth-day serum vaspin concentrations in small-, appropriate-, and large-for-gestational age neonates
  11. Growth patterns in pubertal HIV-infected adolescents and their correlation with cytokines, IGF-1, IGFBP-1, and IGFBP-3
  12. Estrogen receptor α gene analysis in girls with central precocious puberty
  13. Trends of body composition among adolescents according to maturation stage and body mass index
  14. Oxidized low-density lipoprotein levels and carotid intima-media thickness as markers of early atherosclerosis in prepubertal obese children
  15. Interaction of bone mineral density, adipokines and hormones in obese adolescents girls submitted in an interdisciplinary therapy
  16. The contribution of art therapy in poorly controlled youth with type 1 diabetes mellitus
  17. NOX, the main regulator in oxidative stress in experimental models of phenylketonuria?
  18. Changes in growth pattern, leptin ghrelin and neuropeptide Y levels after adenotonsillectomy in prepubertal children
  19. Impact of inborn errors of metabolism on admission in a neonatal intensive care unit: a 4-year report
  20. Correlation between bone mineral density measured by peripheral and central dual energy X-ray absorptiometry in healthy Indian children and adolescents aged 10–18 years
  21. Thyroid-stimulating hormone (TSH) level in nutritionally obese children and metabolic co-morbidity
  22. Hepatocyte growth factor as an indicator of neonatal maturity
  23. Pathophysiology of critical illness hyperglycemia in children
  24. The influence of exposure to maternal diabetes in utero on the rate of decline in β-cell function among youth with diabetes
  25. Clinical and molecular characterization of Chilean patients with Léri-Weill dyschondrosteosis
  26. Abdominal aorta intima media thickness in obese children
  27. Patient reports
  28. KCNJ11 in-frame 15-bp deletion leading to glibenclamide- responsive neonatal diabetes mellitus in a Chinese child
  29. Hoffmann’s syndrome and pituitary hyperplasia in an adolescent secondary to Hashimoto thyroiditis
  30. Late diagnosis of Cushing’s disease in a child: what lessons can be learned?1)
  31. Variable phenotype in five patients with Wolcott-Rallison syndrome due to the same EIF2AK3 (c.1259delA) mutation
  32. Recurrent infantile hypoglycemia due to combined fructose-1,6-diphosphatase deficiency and growth hormone deficiency
  33. A previously undescribed mutation detected by sequence analysis of CYP21A2 gene in an infant with salt wasting congenital adrenal hyperplasia
  34. Transient neonatal hyperparathyroidism: a presenting feature of sialidosis type II
  35. Effect of recombinant insulin-like growth factor-1 treatment on short-term linear growth in a child with Majewski osteodysplastic primordial dwarfism type II and hepatic insufficiency
  36. Duplication of dosage sensitive sex reversal area in a 46, XY patient with normal sex determining region of Y causing complete sex reversal
  37. The search for ectopic ACTH production in a 9-year-old boy
  38. Development of antibodies against growth hormone (GH) during rhGH therapy in a girl with idiopathic GH deficiency: a case report
  39. Ovotesticular disorder of sexual development and a rare 46,XX/47,XXY karyotype
  40. Brachydactyly mental retardation syndrome in differential diagnosis of pseudopseudohypoparathyroidism
  41. Letters to the Editors
  42. How much truth is there in the association between endometriosis and atherosclerosis?
  43. Delayed cord clamping in plethoric term neonates of diabetic mothers: friend or foe?
  44. Meetings
  45. Meetings Calendar
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