Hoffmann’s syndrome and pituitary hyperplasia in an adolescent secondary to Hashimoto thyroiditis
-
Ayse Nurcan Cebeci
,
Ayla Güven
Abstract
Background: Diffuse muscle hypertrophy is a rare complication of acquired hypothyroidism. When accompanied by stiffness, weakness, and painful muscle cramps, the condition is known as Hoffmann’s syndrome (HS). HS is usually seen in young adults due to long-standing untreated primary hypothyroidism. We report a very rare case of HS with muscle hypertrophy and pituitary hyperplasia complicating hypothyroidism in an adolescent.
Case: A 12-year-old male admitted with muscle pain, headache, and fatigue. He had marked hypertrophy of both calf and shoulder muscles. Laboratory tests indicated elevated muscle enzymes and lipids with an elevated thyrotropin and low thyroxine levels. Hashimoto thyroiditis was confirmed on thyroid studies. He had also papilledema bilaterally and magnetic resonance imaging showed an enlargement of the pituitary gland. Treatment with thyroid hormone resulted in complete improvement of symptoms within 3 months.
Conclusions: HS is a rare but treatable form of acquired myopathies and can be seen in children due to untreated hypothyroidism. All patients with an acquired myopathy and muscular pseudohypertrophy should be screened regarding thyroid hormones.
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Artikel in diesem Heft
- Masthead
- Masthead
- Editorials
- Editorial
- Precocious puberty and diagnostic tests
- Review article
- The influence of carbohydrate quality on cardiovascular disease, the metabolic syndrome, type 2 diabetes, and obesity – an overview
- Original Articles
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- Estrogen receptor α gene analysis in girls with central precocious puberty
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- Oxidized low-density lipoprotein levels and carotid intima-media thickness as markers of early atherosclerosis in prepubertal obese children
- Interaction of bone mineral density, adipokines and hormones in obese adolescents girls submitted in an interdisciplinary therapy
- The contribution of art therapy in poorly controlled youth with type 1 diabetes mellitus
- NOX, the main regulator in oxidative stress in experimental models of phenylketonuria?
- Changes in growth pattern, leptin ghrelin and neuropeptide Y levels after adenotonsillectomy in prepubertal children
- Impact of inborn errors of metabolism on admission in a neonatal intensive care unit: a 4-year report
- Correlation between bone mineral density measured by peripheral and central dual energy X-ray absorptiometry in healthy Indian children and adolescents aged 10–18 years
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- Hepatocyte growth factor as an indicator of neonatal maturity
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- Abdominal aorta intima media thickness in obese children
- Patient reports
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- Effect of recombinant insulin-like growth factor-1 treatment on short-term linear growth in a child with Majewski osteodysplastic primordial dwarfism type II and hepatic insufficiency
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- The search for ectopic ACTH production in a 9-year-old boy
- Development of antibodies against growth hormone (GH) during rhGH therapy in a girl with idiopathic GH deficiency: a case report
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- Brachydactyly mental retardation syndrome in differential diagnosis of pseudopseudohypoparathyroidism
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