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Umbilical cord and fifth-day serum vaspin concentrations in small-, appropriate-, and large-for-gestational age neonates

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Veröffentlicht/Copyright: 20. Juni 2012
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 26 Heft 7-8

Abstract

Background: Vaspin is a visceral adipose tissue-derived serine protease inhibitor that has an insulin-sensitizing effect. It is correlated with insulin resistance and glucose metabolism, and it improves glucose tolerance.

Aim: The aim of this study was to determine and compare serum vaspin and insulin concentrations in small-for- gestational age (SGA), appropriate-for-gestational age (AGA), and large-for-gestational age (LGA) infants at birth and fifth postnatal day.

Patients and methods: Eighty-two neonates were divided into three groups: SGA (n=22), AGA (n=30), and LGA (n=30). Mothers’ age, gestational week, mode of delivery, and maternal diseases, such as diabetes, pre-eclampsia, and eclampsia were recorded. Blood for vaspin, insulin, and glucose was collected from the cord at birth and from a peripheral vein on the fifth postnatal day.

Results: At birth, there were no statistically significant difference in serum insulin concentrations among the three groups, whereas cord serum vaspin concentrations were significantly higher in the SGA group (χ2=8.158, p<0.05). Serum glucose and vaspin levels on the fifth postnatal day had no significant difference among three groups (p<0.05). Circulating vaspin concentrations were not associated with the sex of the infant and delivery route.

Conclusion: Cord vaspin levels are significantly higher in SGA neonates than in AGA or LGA neonates. The fetal programming hypothesis proposes that many adulthood diseases originate from the adaptation that the fetus makes when it is undernourished. High cord-vaspin levels in SGA infants may be one of the adaptations for increased risk for adult metabolic diseases.

Keywords: appropriate for gestational age; insulin; large for gestational age; newborn; small for gestational age; vaspin
Ahmet Akcay and Melek Akar collected the data, Gamze Demirel wrote the manuscript, Fuat Emre Canpolat critically reviewed and evaluated the statistical data, and Omer Erdeve and Ugur Dilmen reviewed the manuscript.
Corresponding author: Gamze Demirel, MD, Neonatal Intensive Care Unit, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey, Phone: +90 532 4540156, +90 312 3065271, Fax: +90 312 2362101

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Received: 2012-4-7
Accepted: 2012-5-6
Published Online: 2012-06-20
Published in Print: 2013-08-01

©2013 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/jpem-2012-0111
Schlagwörter für diesen Artikel
appropriate for gestational age; insulin; large for gestational age; newborn; small for gestational age; vaspin

Artikel in diesem Heft

  1. Masthead
  2. Masthead
  3. Editorials
  4. Editorial
  5. Precocious puberty and diagnostic tests
  6. Review article
  7. The influence of carbohydrate quality on cardiovascular disease, the metabolic syndrome, type 2 diabetes, and obesity – an overview
  8. Original Articles
  9. Triptorelin depot stimulation test for central precocious puberty
  10. Umbilical cord and fifth-day serum vaspin concentrations in small-, appropriate-, and large-for-gestational age neonates
  11. Growth patterns in pubertal HIV-infected adolescents and their correlation with cytokines, IGF-1, IGFBP-1, and IGFBP-3
  12. Estrogen receptor α gene analysis in girls with central precocious puberty
  13. Trends of body composition among adolescents according to maturation stage and body mass index
  14. Oxidized low-density lipoprotein levels and carotid intima-media thickness as markers of early atherosclerosis in prepubertal obese children
  15. Interaction of bone mineral density, adipokines and hormones in obese adolescents girls submitted in an interdisciplinary therapy
  16. The contribution of art therapy in poorly controlled youth with type 1 diabetes mellitus
  17. NOX, the main regulator in oxidative stress in experimental models of phenylketonuria?
  18. Changes in growth pattern, leptin ghrelin and neuropeptide Y levels after adenotonsillectomy in prepubertal children
  19. Impact of inborn errors of metabolism on admission in a neonatal intensive care unit: a 4-year report
  20. Correlation between bone mineral density measured by peripheral and central dual energy X-ray absorptiometry in healthy Indian children and adolescents aged 10–18 years
  21. Thyroid-stimulating hormone (TSH) level in nutritionally obese children and metabolic co-morbidity
  22. Hepatocyte growth factor as an indicator of neonatal maturity
  23. Pathophysiology of critical illness hyperglycemia in children
  24. The influence of exposure to maternal diabetes in utero on the rate of decline in β-cell function among youth with diabetes
  25. Clinical and molecular characterization of Chilean patients with Léri-Weill dyschondrosteosis
  26. Abdominal aorta intima media thickness in obese children
  27. Patient reports
  28. KCNJ11 in-frame 15-bp deletion leading to glibenclamide- responsive neonatal diabetes mellitus in a Chinese child
  29. Hoffmann’s syndrome and pituitary hyperplasia in an adolescent secondary to Hashimoto thyroiditis
  30. Late diagnosis of Cushing’s disease in a child: what lessons can be learned?1)
  31. Variable phenotype in five patients with Wolcott-Rallison syndrome due to the same EIF2AK3 (c.1259delA) mutation
  32. Recurrent infantile hypoglycemia due to combined fructose-1,6-diphosphatase deficiency and growth hormone deficiency
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  37. The search for ectopic ACTH production in a 9-year-old boy
  38. Development of antibodies against growth hormone (GH) during rhGH therapy in a girl with idiopathic GH deficiency: a case report
  39. Ovotesticular disorder of sexual development and a rare 46,XX/47,XXY karyotype
  40. Brachydactyly mental retardation syndrome in differential diagnosis of pseudopseudohypoparathyroidism
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  42. How much truth is there in the association between endometriosis and atherosclerosis?
  43. Delayed cord clamping in plethoric term neonates of diabetic mothers: friend or foe?
  44. Meetings
  45. Meetings Calendar
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