Startseite Temporary brittle bone disease: association with intracranial bleeding
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Temporary brittle bone disease: association with intracranial bleeding

  • Colin R. Paterson EMAIL logo und Elizabeth A. Monk
Veröffentlicht/Copyright: 15. Februar 2013
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 26 Heft 5-6

Abstract

We report 20 infants aged between 1 month and 6 months found to have subdural bleeding and also multiple unexplained fractures in a pattern similar to that described earlier as temporary brittle bone disease. Child abuse seemed unlikely as a cause of the fractures as in no case was there clinical evidence of injury commensurate with the fracturing, as some patients had fractures while in hospital and as metaphyseal lesions, when present, were often symmetrical in distribution. Abuse seemed unlikely to have been the cause of the subdural bleeding in several patients; three had clear histories of accidental injury and five had evidence that the initial bleeding was likely to have taken place at birth. Abuse also seemed unlikely as the cause of the syndrome; the nine patients who were returned to their parents had no subsequent allegations of abuse with a mean follow-up period of 15.8 years. The finding of hypermobile joints in the parents of eight of the children is an additional pointer to a natural cause for this condition. The cause of this combination of fractures and subdural bleeding is not yet clear but it is important to be aware that it can result from natural disease.

Keywords: bone disease; fractures; intracranial bleeding; non-accidental injury
Corresponding author: Colin R. Paterson, Temple Oxgates, Longforgan, Dundee DD2 5HS, UK, Phone: +44 1382 360240

We thank Dr. Alistair Hunter for the initial preparation of a database of the clinical findings in these patients. We are indebted to Dr. Michael Hellier, Dr. Elspeth Paterson and Dr. Waney Squier for critical reviews of this paper in draft. We thank Miss Emma Alexander for preparing the figure and Ms Kirsteen Bovill for excellent secretarial help.

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Received: 2012-8-22
Accepted: 2012-12-18
Published Online: 2013-02-15
Published in Print: 2013-05-01

©2013 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/jpem-2012-0272
Schlagwörter für diesen Artikel
bone disease; fractures; intracranial bleeding; non-accidental injury

Artikel in diesem Heft

  1. Masthead
  2. Masthead
  3. Editorial
  4. Success has many fathers, failure is orphan
  5. Review Article
  6. Normosmic idiopathic hypogonadotropic hypogonadism: update on the genetic background and future challenges
  7. Original Articles
  8. Temporary brittle bone disease: association with intracranial bleeding
  9. Asymmetric dimethylarginine (ADMA) and L-arginine levels in children with glycogen storage disease type I
  10. Application of liquid chromatography-tandem mass spectrometry in the diagnosis and follow-up of maple syrup urine disease in a Chinese population
  11. The role of uncoupling protein 2 and 3 genes polymorphism and energy expenditure in obese Indonesian children
  12. Thyroid dysfunctions of prematurity and their impacts on neurodevelopmental outcome1)
  13. Frequency of the E23K polymorphism of the KCNJ11 gene in children born small for gestational age and its influence on auxological and metabolic parameters in the prepubertal period
  14. Reference intervals for serum thyroid hormones in preterm hospitalized infants1)
  15. The clinical and biochemical presentation of vitamin D deficiency and insufficiency in children and adolescents
  16. A risk score for identifying overweight adolescents with dysglycemia in primary care settings1)
  17. Thyroid function and morphology in overweight and obese children and adolescents in a Chinese population
  18. Propionic acidaemia: demographic characteristics and complicationsa
  19. Negative correlation between serum IL-6 level and cardiorespiratory fitness in 10- to 11-year-old boys with increased BMI
  20. Penile length and genital anomalies in Egyptian male newborns: epidemiology and influence of endocrine disruptors
  21. Efficacy of vitamin D loading doses on serum 25-hydroxy vitamin D levels in school going adolescents: an open label non-randomized prospective trial
  22. Characteristics of infants admitted with hypoglycemia to a neonatal unit
  23. Increasing thyroid-stimulating hormone is associated with impaired glucose metabolism in euthyroid obese children and adolescents
  24. The role of FTO genotype on eating behavior in obese Sardinian children and adolescents
  25. Prevalence of multiple forms of autoimmunity in Egyptian patients with Turner syndrome: relation to karyotype
  26. A novel DAX-1 mutation presented with precocious puberty and hypogonadotropic hypogonadism in different members of a large pedigree
  27. Patient Reports
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  29. Diabetic ketoacidosis with cerebral hemorrhage and alpha coma in an adolescent female
  30. A novel mutation in thyrotropin (thyroid-stimulating hormone) gene in congenital hypothyroidism
  31. Citric acid as the last therapeutic approach in an acute life-threatening metabolic decompensation of propionic acidaemia
  32. A case of autosomal dominant osteopetrosis type II with a novel TCIRG1 gene mutation
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  38. A rare case of isolated Cushing syndrome in a 3-month-old boy
  39. Letters to the Editors
  40. Gynecomastia in puberty is usually asymptomatic and regresses spontaneously
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