Startseite Medizin Negative correlation between serum IL-6 level and cardiorespiratory fitness in 10- to 11-year-old boys with increased BMI
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Negative correlation between serum IL-6 level and cardiorespiratory fitness in 10- to 11-year-old boys with increased BMI

  • Liina Utsal EMAIL logo , Vallo Tillmann , Mihkel Zilmer , Jarek Mäestu , Priit Purge , Meeli Saar , Evelin Lätt , Katre Maasalu , Toivo Jürimäe und Jaak Jürimäe
Veröffentlicht/Copyright: 18. März 2013
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 26 Heft 5-6

Abstract

Background/Aims: Some markers of inflammation have been found to be associated with cardiorespiratory fitness levels, but only few studies have studied this in overweight children. The aim of this study was to investigate associations between markers of inflammation and the fitness levels measured by peak oxygen consumption (VO2peak and VO2peak/kg) in boys with increased body mass index (BMI) and with normal BMI.

Participants/Methods: Subjects were 38 boys with BMI above 85th percentile (OWB) and 38 boys with normal BMI (NWB) at the age of 10 to 11 years. Serum concentrations of IL-2, IL-4, IL-6, IL-8, IL-10, VEGF, IFNγ, TNF-α, IL-1α, IL-1β, MCP-1, EGF, CRP and associations with measured cardiorespiratory fitness levels were studied. High-sensitive chips were used to measure 13 markers of inflammation.

Results: Mean VO2peak was significantly higher (2.1±0.3 vs. 1.8±0.3 L/min; p<0.05) and mean VO2peak/kg significantly lower (33.7±4.7 vs. 48.9±6.4 mL/min/kg; p<0.05) in OWB than in NWB group. Out of 13 measured biochemical markers IL-6 correlated with VO2peak/kg (r=–0.37; p<0.05) and TNF-α with VO2peak (r=0.41; p<0.01) in OWB. BMI and IL-6 together explained 44.5% of the variability of VO2peak/kg in the OWB group.

Conclusions: Overweight boys had lower cardiorespiratory fitness level measured by VO2peak/kg and this was negatively correlated with serum IL-6 level. Measurement of serum IL-6 level in overweight boys may help to identify subjects who need specific exercise formats to achieve maximal beneficial health effects and to reduce their risk for the development of type 2 diabetes and atherosclerosis later in life.

Keywords: inflammation; obesity; oxygen consumption; prepubertal boys
Corresponding author: Liina Utsal, Faculty of Exercise and Sport Sciences, University of Tartu, 50090, Tartu, Estonia, Phone: +37-27375372, Fax: +37-27375373

This study was partly supported by the Estonian Ministry of Education grants TKKSP 0489 and GKKSP 9168.

Conflict of interest statement

Disclosure statement: The authors have nothing to disclose.

References

1. Meyer AA, Kundt G, Steiner M, Schuff-Werner P, Kienast W. Impaired flow-mediated vasodilation, carotid artery intima-media thickening, and elevated endothelial plasma markers in obese children: the impact of cardiovascular risk factors. Pediatrics 2006;117:1560–7.Suche in Google Scholar

2. Raj M. Obesity and cardiovascular risk in children and adolescents. Indian J Endocrinol Metab 2012;16:13–19.Suche in Google Scholar

3. Blake GJ, Ridker PM. Inflammatory biomarkers and cardiovascular risk prediction. J Int Med 2002;252:283–94.Suche in Google Scholar

4. Utsal L, Tillmann V, Zilmer M, Mäestu J, Purge P, et al. Elevated serum IL-6, IL-8, MCP-1, CRP and IFNγ levels in 10- to 11- year-old boys with increased BMI. Horm Res Paediatr 2012;78:31–9.Suche in Google Scholar

5. Glowinska B, Urban M. Selected cytokines (IL-6, IL-8, IL-10, MCP-1, TNF-alpha) in children and adolescents with atherosclerosis risk factors: obesity, hypertension, diabetes. Wiad Lek 2003;56:109–16.Suche in Google Scholar

6. Ridker PM, Rifai N, Meir J, Hennekens S, Hennekens CH. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 2000;101: 1767–72.Suche in Google Scholar

7. Pradham AD, Manson JAE, Rifai N, Buring JE, Ridker PM: C-Reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. J Am Med Assoc 2001;286:327–34.Suche in Google Scholar

8. Martins CL, Silva F, Gaya AR, Aires L, Ribeiro JC, et al. Cardiorespiratory fitness, fatness, and cardiovascular disease risk factors in children and adolescents from Porto. Eur J Sport Sci 2010;10:121–7.Suche in Google Scholar

9. Rodrigues AN, Perez AJ, Carletti R, Bissoli NS, Abreu GR. The association between cardiorespiratory fitness and cardiovascular risk in adolescents. J Pediatr 2007; 83:429–35.Suche in Google Scholar

10. Gaeni A-A, Fallahi A-A, Kazemi A, Kordi R. Association between cardiovascular fitness and inflammatory markers in boys aged 11-14 years. Iran J Pediatr 2009;19:262–70.Suche in Google Scholar

11. Nemet D, Wang P, Funahashi T, Matsuzawa Y, Tanaka S, et al. Adipocytokines, body composition, and fitness in children. Pediatr Res 2003;53:148–52.Suche in Google Scholar

12. Berndtsson G, Mattsson E, Marcus C, Larsson UE. Age and gender differences in VO2max in Swedish obese children and adolescents. Acta Paediatr 2007;96:567–571.Suche in Google Scholar

13. Rosa JS, Heydari S, Oliver SR, Rebecca LF, Pontello A, et al. Inflammatory cytokine profiles during exercise in obese, diabetic, and healthy children. J Clin Res Pediatr Endocrinol 2011;9:115–21.Suche in Google Scholar

14. Eliakim A, Swindt C, Zaldivar F, Casali P, Cooper DM. Reduced tetanus antibody titers in overweight children. Autoimmunity 2006;39:137–41.Suche in Google Scholar

15. Kullo IJ, Khaleghi M, Hensrud DD. Markers of inflammation are inversely associated with VO2max in asymptomatic men. J Appl Physiol 2007;102:1374–9.Suche in Google Scholar

16. Alvarez JA, Higgins PB, Oster RA, Fernandez JR, Darnell BE, et al. Fasting and postprandial markers of inflammation in lean and overweight children. Am J Clin Nutr 2009;89: 1138–44.Suche in Google Scholar

17. Wärnberg J, Cunningham K, Romeo J, Marcos A. Physical activity, exercise and lowgrade systemic inflammation. Proc Nutr Soc 2010;69:400–6.Suche in Google Scholar

18. Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Rimm EB. Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res 2003; 11:1055–64.Suche in Google Scholar

19. Zorba E, Cengiz T, Karacabey K. Exercise training improves body composition, blood lipid profile and serum insulin levels in obese children. J Sports Med Phys Fitness 2011;51:664–9.Suche in Google Scholar

20. McInnis KJ, Franklin BA, Rippe JM. Counseling for physical activity in overweight and obese patients. Am Fam Physician 2003;67:1249–56.Suche in Google Scholar

21. Lazzer S, Lafortuna C, Busti, C, Galli R, Agosti F, et al. Effects of low- and high-intensity exercise training on body composition and substrate metabolism in obese adolescents. J Endocrinol Invest 2011;34:45–52.Suche in Google Scholar

22. Hajer GR, Haeften TW, Visseren FLJ. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 2008;29:2959–71.Suche in Google Scholar

23. Trayhurn P, Beattie JH. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 2001;60:329–39.Suche in Google Scholar

Received: 2012-10-21
Accepted: 2013-2-4
Published Online: 2013-03-18
Published in Print: 2013-05-01

©2013 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/jpem-2012-0338
Schlagwörter für diesen Artikel
inflammation; obesity; oxygen consumption; prepubertal boys

Artikel in diesem Heft

  1. Masthead
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  3. Editorial
  4. Success has many fathers, failure is orphan
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  11. The role of uncoupling protein 2 and 3 genes polymorphism and energy expenditure in obese Indonesian children
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