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Frequency of the E23K polymorphism of the KCNJ11 gene in children born small for gestational age and its influence on auxological and metabolic parameters in the prepubertal period

  • Renata Stawerska , Małgorzata Szałapska , Maciej Borowiec , Wojciech Młynarski , Karolina Antosik , Maciej Hilczer and Andrzej Lewiński EMAIL logo
Published/Copyright: February 15, 2013
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 26 Issue 5-6

Abstract

Background: The E23K variant of the KCNJ11 gene is possibly responsible for changes in insulin secretion during the fetal life. We tried to assess the influence of the E23K variant on birth weight and metabolic profile in prepubertal children born small for gestational age (SGA).

Subjects: One hundred and twenty-three SGA and 132 born appropriate for gestational age (AGA) children were genotyped for the E23K variant. Lipids, glucose, and insulin concentrations during oral glucose tolerance test were assessed in 112 SGA prepubertal children.

Results: There were no significant differences between the frequency of the E23K variant in SGA and AGA children. In SGA children with E23K, the mean birth weight was significantly higher than in the E23E group. Body mass index, glucose, insulin, and lipids were not different between the E23K, E23E, and K23K groups.

Conclusions: The higher birth weight in SGA children with the E23K variant may be related to higher insulin concentrations in the fetal period. The E23K variant did not affect metabolic disorders in prepubertal SGA children.

Keywords: insulin; Kir6.2; lipids; polymorphism E23K; prepubertal children; small for gestational age
Corresponding author: Andrzej Lewiński, Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital Research Institute, 93-338 Lodz, Rzgowska 281/289, Poland, Phone/Fax: +48 42 271 13 43

This study was supported by funds from the Ministry of Scientific Research and Information Technology of Poland, project no. 2751/P01/2007/32.

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Received: 2012-6-20
Accepted: 2012-12-22
Published Online: 2013-02-15
Published in Print: 2013-05-01

©2013 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/jpem-2012-0196
Keywords for this article
insulin; Kir6.2; lipids; polymorphism E23K; prepubertal children; small for gestational age

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Editorial
  4. Success has many fathers, failure is orphan
  5. Review Article
  6. Normosmic idiopathic hypogonadotropic hypogonadism: update on the genetic background and future challenges
  7. Original Articles
  8. Temporary brittle bone disease: association with intracranial bleeding
  9. Asymmetric dimethylarginine (ADMA) and L-arginine levels in children with glycogen storage disease type I
  10. Application of liquid chromatography-tandem mass spectrometry in the diagnosis and follow-up of maple syrup urine disease in a Chinese population
  11. The role of uncoupling protein 2 and 3 genes polymorphism and energy expenditure in obese Indonesian children
  12. Thyroid dysfunctions of prematurity and their impacts on neurodevelopmental outcome1)
  13. Frequency of the E23K polymorphism of the KCNJ11 gene in children born small for gestational age and its influence on auxological and metabolic parameters in the prepubertal period
  14. Reference intervals for serum thyroid hormones in preterm hospitalized infants1)
  15. The clinical and biochemical presentation of vitamin D deficiency and insufficiency in children and adolescents
  16. A risk score for identifying overweight adolescents with dysglycemia in primary care settings1)
  17. Thyroid function and morphology in overweight and obese children and adolescents in a Chinese population
  18. Propionic acidaemia: demographic characteristics and complicationsa
  19. Negative correlation between serum IL-6 level and cardiorespiratory fitness in 10- to 11-year-old boys with increased BMI
  20. Penile length and genital anomalies in Egyptian male newborns: epidemiology and influence of endocrine disruptors
  21. Efficacy of vitamin D loading doses on serum 25-hydroxy vitamin D levels in school going adolescents: an open label non-randomized prospective trial
  22. Characteristics of infants admitted with hypoglycemia to a neonatal unit
  23. Increasing thyroid-stimulating hormone is associated with impaired glucose metabolism in euthyroid obese children and adolescents
  24. The role of FTO genotype on eating behavior in obese Sardinian children and adolescents
  25. Prevalence of multiple forms of autoimmunity in Egyptian patients with Turner syndrome: relation to karyotype
  26. A novel DAX-1 mutation presented with precocious puberty and hypogonadotropic hypogonadism in different members of a large pedigree
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  29. Diabetic ketoacidosis with cerebral hemorrhage and alpha coma in an adolescent female
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