The role of FTO genotype on eating behavior in obese Sardinian children and adolescents
-
Anastasia Ibba
Abstract
Aim: We aimed to study the influence of the fat mass and obesity-associated (FTO) gene on eating behavior in 412 obese Sardinian children and adolescents. Genome-wide association studies (GWAS) have identified several susceptibility loci for obesity. Among these, the polymorphisms in the intron 1 of the FTO gene has been found associated to weight gain and obesity in various populations.
Methods: All obese patients were genotyped for the FTO single nucleotide polimorphysm (SNP) rs9939609. In all subjects we evaluated eating behavior using the Child Eating Behaviour Questionnaire (CEBQ).
Results: We found no differences in eating behavior according to the genotype, either in the entire cohort, or when subjects were subdivided into four different age groups.
Conclusions: FTO genotype is associated with body mass index but does not influence eating behavior in a selected cohort of obese children from the isolated genetic population of Sardinia.
We are grateful to our nursing staff (Donatella Arghittu, Valentina Bianco, Patrizia Sanna) and our laboratory technicians (Maria Grazia Contini, Danilo Mosinu, Teresa Trogu) for their invaluable contribution and support.
Supported by a grant from Regione Autonoma della Sardegna to S. Loche.
Conflicts of interest statement
The authors have no conflicts of interest to disclose.
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©2013 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Masthead
- Masthead
- Editorial
- Success has many fathers, failure is orphan
- Review Article
- Normosmic idiopathic hypogonadotropic hypogonadism: update on the genetic background and future challenges
- Original Articles
- Temporary brittle bone disease: association with intracranial bleeding
- Asymmetric dimethylarginine (ADMA) and L-arginine levels in children with glycogen storage disease type I
- Application of liquid chromatography-tandem mass spectrometry in the diagnosis and follow-up of maple syrup urine disease in a Chinese population
- The role of uncoupling protein 2 and 3 genes polymorphism and energy expenditure in obese Indonesian children
- Thyroid dysfunctions of prematurity and their impacts on neurodevelopmental outcome1)
- Frequency of the E23K polymorphism of the KCNJ11 gene in children born small for gestational age and its influence on auxological and metabolic parameters in the prepubertal period
- Reference intervals for serum thyroid hormones in preterm hospitalized infants1)
- The clinical and biochemical presentation of vitamin D deficiency and insufficiency in children and adolescents
- A risk score for identifying overweight adolescents with dysglycemia in primary care settings1)
- Thyroid function and morphology in overweight and obese children and adolescents in a Chinese population
- Propionic acidaemia: demographic characteristics and complicationsa
- Negative correlation between serum IL-6 level and cardiorespiratory fitness in 10- to 11-year-old boys with increased BMI
- Penile length and genital anomalies in Egyptian male newborns: epidemiology and influence of endocrine disruptors
- Efficacy of vitamin D loading doses on serum 25-hydroxy vitamin D levels in school going adolescents: an open label non-randomized prospective trial
- Characteristics of infants admitted with hypoglycemia to a neonatal unit
- Increasing thyroid-stimulating hormone is associated with impaired glucose metabolism in euthyroid obese children and adolescents
- The role of FTO genotype on eating behavior in obese Sardinian children and adolescents
- Prevalence of multiple forms of autoimmunity in Egyptian patients with Turner syndrome: relation to karyotype
- A novel DAX-1 mutation presented with precocious puberty and hypogonadotropic hypogonadism in different members of a large pedigree
- Patient Reports
- Pseudohypoparathyroidism type Ia: a novel GNAS mutation in a Brazilian boy presenting with an early primary hypothyroidism
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- A case of autosomal dominant osteopetrosis type II with a novel TCIRG1 gene mutation
- The interpretation of color – an endocrine cause of skin discoloration mimicking cyanosis
- Novel heterozygous thyrotropin receptor mutation presenting with neonatal hyperthyrotropinaemia, mild thyroid hypoplasia and absent uptake on radioisotope scan
- Turner Syndrome and apparent absent uterus: a case report and review of the literature
- 10.1515/jpem-2012-0133
- Vaginal bleeding in a 4-month-old preterm girl: extreme minipuberty mimicking central precocious puberty
- A rare case of isolated Cushing syndrome in a 3-month-old boy
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- Gynecomastia in puberty is usually asymptomatic and regresses spontaneously
- Is endometriosis ultimately the end result of the interplay between interferon-γ (IFN-γ) and the HOXA10 gene network?
- Does treatment with L-selenomethionine reduce thyroid volume in euthyroid children with autoimmune thyroiditis?
- Meetings
- Meetings Calendar
