Startseite Medizin Prevalence of multiple forms of autoimmunity in Egyptian patients with Turner syndrome: relation to karyotype
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Prevalence of multiple forms of autoimmunity in Egyptian patients with Turner syndrome: relation to karyotype

  • Rasha T. Hamza EMAIL logo , Nader A. Raof und Khaled O. Abdallah
Veröffentlicht/Copyright: 26. Oktober 2012
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 26 Heft 5-6

Abstract

Our study aimed to investigate: the prevalence of autoantibodies related to organ-specific disease; the prevalence of some autoimmune diseases (AID) in Egyptian Turner syndrome (TS) patients; and the association of autoimmunity with patients’ karyotypes. Eighty TS patients were subjected to history, auxological assessment and measurement of antithyroid peroxidase antibody (ATPOAb), antithyroglobulin antibody (ATGAb), anti-tissue transglutaminase IgA antibodies (ATTIgAAb), anti-glutamic acid decarboxylase-65 antibodies (GAD-65-Ab) and anti-adrenal cortex antibodies (AACAb). Of the 80 TS patients, 54 (67.5%) were seropositive for one or more autoantibodies. Thirty-five percent were positive for ATPOAb, 15% for ATGAb, 12.5% for ATTIgAAb, 3.75% for Anti-GAD-65Ab and 1.25% for AACAb. There was a non-significant association between the 45,X karyotype and overall prevalence of autoantibodies (p=0.20), while IsoXq was associated with increased prevalence of ATPOAb (p<0.01), ATGAb (p=0.01) and anti-GAD-65Ab (p=0.02). Thus, female TS patients face a high prevalence of autoimmunity and associated AID.

Keywords: antibodies; autoimmunity; Egyptian; karyotype; Turner syndrome
Corresponding author: Rasha T. Hamza, MD, Assistant Professor of Pediatrics and Pediatric Endocrinology, Faculty of Medicine, Department of Pediatrics, Ain Shams University, 36 Hisham Labib street, off Makram Ebeid street, Nasr City, Cairo, 11371, Egypt, Phone: +202 22734727, Fax: +202 26904430

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Received: 2012-8-13
Accepted: 2012-9-17
Published Online: 2012-10-26
Published in Print: 2013-05-01

©2013 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/jpem-2012-0265
Schlagwörter für diesen Artikel
antibodies; autoimmunity; Egyptian; karyotype; Turner syndrome

Artikel in diesem Heft

  1. Masthead
  2. Masthead
  3. Editorial
  4. Success has many fathers, failure is orphan
  5. Review Article
  6. Normosmic idiopathic hypogonadotropic hypogonadism: update on the genetic background and future challenges
  7. Original Articles
  8. Temporary brittle bone disease: association with intracranial bleeding
  9. Asymmetric dimethylarginine (ADMA) and L-arginine levels in children with glycogen storage disease type I
  10. Application of liquid chromatography-tandem mass spectrometry in the diagnosis and follow-up of maple syrup urine disease in a Chinese population
  11. The role of uncoupling protein 2 and 3 genes polymorphism and energy expenditure in obese Indonesian children
  12. Thyroid dysfunctions of prematurity and their impacts on neurodevelopmental outcome1)
  13. Frequency of the E23K polymorphism of the KCNJ11 gene in children born small for gestational age and its influence on auxological and metabolic parameters in the prepubertal period
  14. Reference intervals for serum thyroid hormones in preterm hospitalized infants1)
  15. The clinical and biochemical presentation of vitamin D deficiency and insufficiency in children and adolescents
  16. A risk score for identifying overweight adolescents with dysglycemia in primary care settings1)
  17. Thyroid function and morphology in overweight and obese children and adolescents in a Chinese population
  18. Propionic acidaemia: demographic characteristics and complicationsa
  19. Negative correlation between serum IL-6 level and cardiorespiratory fitness in 10- to 11-year-old boys with increased BMI
  20. Penile length and genital anomalies in Egyptian male newborns: epidemiology and influence of endocrine disruptors
  21. Efficacy of vitamin D loading doses on serum 25-hydroxy vitamin D levels in school going adolescents: an open label non-randomized prospective trial
  22. Characteristics of infants admitted with hypoglycemia to a neonatal unit
  23. Increasing thyroid-stimulating hormone is associated with impaired glucose metabolism in euthyroid obese children and adolescents
  24. The role of FTO genotype on eating behavior in obese Sardinian children and adolescents
  25. Prevalence of multiple forms of autoimmunity in Egyptian patients with Turner syndrome: relation to karyotype
  26. A novel DAX-1 mutation presented with precocious puberty and hypogonadotropic hypogonadism in different members of a large pedigree
  27. Patient Reports
  28. Pseudohypoparathyroidism type Ia: a novel GNAS mutation in a Brazilian boy presenting with an early primary hypothyroidism
  29. Diabetic ketoacidosis with cerebral hemorrhage and alpha coma in an adolescent female
  30. A novel mutation in thyrotropin (thyroid-stimulating hormone) gene in congenital hypothyroidism
  31. Citric acid as the last therapeutic approach in an acute life-threatening metabolic decompensation of propionic acidaemia
  32. A case of autosomal dominant osteopetrosis type II with a novel TCIRG1 gene mutation
  33. The interpretation of color – an endocrine cause of skin discoloration mimicking cyanosis
  34. Novel heterozygous thyrotropin receptor mutation presenting with neonatal hyperthyrotropinaemia, mild thyroid hypoplasia and absent uptake on radioisotope scan
  35. Turner Syndrome and apparent absent uterus: a case report and review of the literature
  36. 10.1515/jpem-2012-0133
  37. Vaginal bleeding in a 4-month-old preterm girl: extreme minipuberty mimicking central precocious puberty
  38. A rare case of isolated Cushing syndrome in a 3-month-old boy
  39. Letters to the Editors
  40. Gynecomastia in puberty is usually asymptomatic and regresses spontaneously
  41. Is endometriosis ultimately the end result of the interplay between interferon-γ (IFN-γ) and the HOXA10 gene network?
  42. Does treatment with L-selenomethionine reduce thyroid volume in euthyroid children with autoimmune thyroiditis?
  43. Meetings
  44. Meetings Calendar
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