ABSTRACT
Background
Adiantum lunulatum Burm. F. leaf (AL) and its related species have been used traditionally for the treatment of various diseases.
Objective
The present study evaluated the hepatoprotective, and antioxidant activities of ethanolic extract of AL.
Methodology and Result
The hepatoprotective effect of AL was evaluated against ethanol-induced hepatotoxicity in rats. Administration of ethanol (2 g/kg) showed a significant biochemical and histological deterioration in the liver of experimental animals. Pretreatment with ethanolic extract of AL (250 and 500 mg/kg b.wt. p.o) significantly reduced the elevated levels of serum enzymes like serum glutamic-oxaloacetic transaminase (AST), serum glutamic-pyruvic transaminase (ALT), alkaline phosphatase (ALP), total protein, total bilirubin and reversed the hepatic damage in the liver which evidenced the hepatoprotective activity. The superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) level notably increased due to doses of AL.
Conclusion
The results of the present study demonstrate that the ethanolic extract of AL possesses hepatoprotective and antioxidant activities.
Graphical Abstract
Abbreviations
- AL
Adiantum lunulatum Burm. F.
- ALP
Alkaline phosphatase
- ALT 250
Treatment with 250 mg/kg EAL
- ALT 500
Treatment with 500 mg/kg EAL
- ALT
alanine aminotransferase
- AST
Aspartate aminotransferase
- CAT
Catalase
- EAL
Ethanolic extract of Adiantum lunulatum Burm. F.
- GPx
Glutathione peroxidase
- HAI
Hepatic activity index
- IEAC
Institutional animal ethics committee
- KBIPER
K.B. Institute of Pharmaceutical Education and Research
- SGOT
serum glutamic-oxaloacetic transaminase
- SGPT
serum glutamic-pyruvic transaminase
- SOD
Superoxide dismutase
Acknowledgment
We acknowledged K. B. Institute of Pharmaceutical Education and Research, Gandhinagar for funding this project.
Author contributions: None declared.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The authors declare no conflicts of interest.
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- Assessment the studies on the concept of Mizaj (temperament) in Persian Medicine
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