Oxidative stress in Vitiligo patients and administration of Munzij and Mushil therapy, a poly herbal Unani formulation – hospital-based study

Towseef Amin Rafeeqi; Farhat Jabeen; M A Waheed; Gulam Mohammed Husain; Alokananda Chakraborthy

doi:10.1515/jcim-2015-0111

Article

Oxidative stress in Vitiligo patients and administration of Munzij and Mushil therapy, a poly herbal Unani formulation – hospital-based study

Towseef Amin Rafeeqi , Farhat Jabeen , M A Waheed , Gulam Mohammed Husain and Alokananda Chakraborthy

Published/Copyright: September 23, 2020

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From the journal Journal of Complementary and Integrative Medicine Volume 17 Issue 3

Abstract

Background

Vitiligo, a skin disorder is viewed as a multifactorial process with major role of reactive oxygen species in concert to destroy or incapacitate melanocytes. In Unani system of medicine the treatment of Bars (Vitiligo) starts with removal of harmful materials from the body with Munzij and Mushil (MM), a poly herbal Unani formulation.

Methods

Herein, oxidative stress related parameters as MDA, SOD, GPx and CAT have been estimated in the 21 clinically diagnosed Vitiligo in-patients and subsequently these parameters were evaluated during and after administration of MM therapy and compared with 21 healthy subjects.

Results

There was significant difference in the parameters viz., SOD (p<0.001) and CAT (p<0.005) activity at the baseline with no statistical significant difference in MDA and GPx activity among Vitiligo subjects and controls. After MM therapy there was no statistical significant difference among the values of these parameters in Vitiligo subjects.

Conclusions

The results suggest that there is imbalance in the oxidant-antioxidant status of Vitiligo subjects and the MM therapy is not found to significantly change the levels of oxidative stress related parameters.

Keywords: Munzij and Mushil therapy; oxidative stress; Unani medicine; Vitiligo

Acknowledgments

We would like to acknowledge Hon'ble DG CCRUM for infrastructure support. We hereby appreciate the participation of the patients as well as the cooperation of the staff especially of Pharmacy section of CRIUM Hyderabad. Further we would like to acknowledge Mrs Nasreen and Ms Jabeen for their help during experimentation.

Author contributions: None declared.
Research funding: Central Council for Research in Unani Medicine, Ministry of AYUSH, Govt. of India and Department of Science & Technology, Ministry of Science & Technology, Govt. of India.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: None declared.

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Received: 2015-10-31

Accepted: 2019-08-29

Published Online: 2020-09-23

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Articles in the same Issue

https://doi.org/10.1515/jcim-2015-0111

Keywords for this article

Munzij and Mushil therapy; oxidative stress; Unani medicine; Vitiligo