Startseite Ameliorative potential of Blighia sapida K.D. Koenig bark against pancreatic β-cell dysfunction in alloxan-induced diabetic rats
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Ameliorative potential of Blighia sapida K.D. Koenig bark against pancreatic β-cell dysfunction in alloxan-induced diabetic rats

  • Oluwafemi Adeleke Ojo EMAIL logo , Basiru Olaitan Ajiboye , Adebola Busola Ojo , Babatunji Emmanuel Oyinloye , Oluwatosin Debbie Imiere und Oluwatosin Adeyonu
Veröffentlicht/Copyright: 17. März 2017
Journal of Complementary and Integrative Medicine
Aus der Zeitschrift Journal of Complementary and Integrative Medicine Band 14 Heft 3

Abstract

Background

In West Africa, the fruit, seed, leaf and stem of Blighia sapida K.D. Koenig are commonly used as remedy against a variety of diseases, including diabetes mellitus. This study investigated the ameliorative potential of B. sapida K.D. Koenig stem bark ethanol extract against pancreatic β-cell dysfunction in diabetic rats.

Methods

Diabetes was induced by intraperitoneal injection of alloxan (65 mg/kg body weight) for 21 days, and orally administered with glibenclamide (5 mg/kg body weight), 50–150 mg/kg body weight of B. sapida stem bark ethanol extract once daily for 21 days.

Results

The blood glucose levels of rats induced with alloxan were significantly and gradually reduced (p<0.05) in B. sapida stem bark ethanol extract treated animals at the dose of 50–150 mg/kg body weight, and in glibenclamide-treated animals. The significant increase in the lipid peroxidation (malonaldehyde), homeostasis model assessment-insulin resistance scores (HOMA-IR) and decrease in serum insulin, pancreatic β-cell scores as well as antioxidant marker enzymes in untreated diabetic rats compared to normal control rats were reversed by the B. sapida stem bark ethanol extract and glibenclamide. Similarly, histopathological changes in the pancreas were also reversed by the extract and glibenclamide. However, these effects were most prominent in the animals treated with 150 mg/kg body weight of B. sapida bark.

Conclusions

These findings indicate that B. sapida stem bark possess anti-hyperglycemic activity and exhibits ameliorative potential in managing diabetes.

Keywords: antioxidant enzymes; Blighia sapida K.D. Koenig ethanol extract; diabetes; insulin resistance; pancreatic β-cell function

Acknowledgement

The authors wish to acknowledge the laboratory assistance of the Department of Biochemistry (Afe Babalola University) for providing the necessary facilities.

  1. Author contributions: Ojo, O. A. designed the experiments. Ojo, A. B. performed experiments, evaluated data, and performed statistical analysis. Ajiboye, B. and Oyinloye, B. directed the research and the preparation of the manuscript. Imiere, O. D. and Adeyonu, O. performed experiments. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2016-11-13
Accepted: 2017-2-9
Published Online: 2017-3-17

© 2017 Walter de Gruyter GmbH, Berlin/Boston

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  1. Review
  2. Cornus mas: a review on traditional uses and pharmacological properties
  3. Preclinical Studies
  4. Anti-inflammatory and immunomodulatory activities of Inula cappa roots (Compositae)
  5. Effects of water extract of Curcuma longa (L.) roots on immunity and telomerase function
  6. Garcinia kola seeds may prevent cognitive and motor dysfunctions in a type 1 diabetes mellitus rat model partly by mitigating neuroinflammation
  7. Changes in some biochemical parameters of alloxanized rats administered with varying concentrations of quail egg solution
  8. Ameliorative potential of Blighia sapida K.D. Koenig bark against pancreatic β-cell dysfunction in alloxan-induced diabetic rats
  9. Comparative evaluation of hypoglycemic and hypolipidemic activity of various extract of Anogeissus latifolia bark in streptozotocin-induced diabetic rats
  10. Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles
  11. Biochemical and electrocardiographic studies on the beneficial effects of gallic acid in cyclophosphamide-induced cardiorenal dysfunction
  12. Clinical Studies
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https://doi.org/10.1515/jcim-2016-0145
Schlagwörter für diesen Artikel
antioxidant enzymes; Blighia sapida K.D. Koenig ethanol extract; diabetes; insulin resistance; pancreatic β-cell function

Artikel in diesem Heft

  1. Review
  2. Cornus mas: a review on traditional uses and pharmacological properties
  3. Preclinical Studies
  4. Anti-inflammatory and immunomodulatory activities of Inula cappa roots (Compositae)
  5. Effects of water extract of Curcuma longa (L.) roots on immunity and telomerase function
  6. Garcinia kola seeds may prevent cognitive and motor dysfunctions in a type 1 diabetes mellitus rat model partly by mitigating neuroinflammation
  7. Changes in some biochemical parameters of alloxanized rats administered with varying concentrations of quail egg solution
  8. Ameliorative potential of Blighia sapida K.D. Koenig bark against pancreatic β-cell dysfunction in alloxan-induced diabetic rats
  9. Comparative evaluation of hypoglycemic and hypolipidemic activity of various extract of Anogeissus latifolia bark in streptozotocin-induced diabetic rats
  10. Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles
  11. Biochemical and electrocardiographic studies on the beneficial effects of gallic acid in cyclophosphamide-induced cardiorenal dysfunction
  12. Clinical Studies
  13. Development and validation of a yoga module for Parkinson disease
  14. Case Report
  15. Return to work program efficacy with Self-Regulation Therapy (SRT®): Case study with complex trauma and concurrent disorders
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