Anti-inflammatory and immunomodulatory activities of Inula cappa roots (Compositae)
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Jyoti Kalola
Abstract
Background
The medicinal properties of Inula cappa, a perennial shrub, are ascribed to its roots. In this article, we study the anti-inflammatory and immunomodulatory activities of I. cappa root extracts based on its utilization in traditional medicine-treatment of rheumatoid arthritis, menoxenia, fever, jaundice and many others.
Methods
Anti-inflammatory and immunomodulatory activities of I. cappa extracts were studied. The anti-inflammatory activity was determined by carrageenan-induced rat paw edema and cotton pellet-induced granulation method while the immunomodulatory activity was estimated by phagocytic assay method, hemagglutinating antibody (HA) titer assay, delayed-type hypersensitivity assay method, plaque forming cell assay and determination of immunoprophylatic activity.
Results
The methanolic extract showed maximum reduction in the rat paw edema and showed significant inhibition of the cotton pellet-induced granulomas in rats. The methanolic extract also showed potential immunomodulatory activity in all the assays performed. Two sesquiterpenes, isoalantolactone and germacranolide were also isolated from the methanolic extract.
Conclusions
The present study supports the evidence that the roots of I. cappa can be used as a potent anti-inflammatory and immunomodulatory agent.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
1. Hooker JD. The flora of British India Vol. 3. London:L. Reeve & Co., 1882:291–296.Search in Google Scholar
2. Manandhar NP. An Inventory of some vegetable drug resources of Makwanpur district, Nepal. Fitoterapia. 1995;66:231–238.Search in Google Scholar
3. Bohlmann F, Ahmed M, Jakupovic J. Inositol angelates from Inula cappa. Phytochemistry. 1982;21:780–782.10.1016/0031-9422(82)83188-9Search in Google Scholar
4. Goswami AC, Baruah RN, Sharma RP, Baruah JN, Kulanthaivel P, Herz W. Germacranolides from Inula cappa. Phytochemistry. 1984;23:367–372.10.1016/S0031-9422(00)80334-9Search in Google Scholar
5. Zheng LH, Hoa XJ, Yuan CM, Huang LJ, Zhang JX, Dong F,et al. Study on chemical constituents of Inula cappa. Zhongguo Zhong Yao Za Zhi. 2015;40:672–678.Search in Google Scholar
6. Guo QL, Yang JS, Lui JX. Studies on the chemical constituents from Inula cappa (II). Zhong Yao Cai. 2007;30:35–37.Search in Google Scholar
7. Wu Z, Shan L, Lu M, Shen Y, Tang J, Zhang W. Chemical constituents from Inula cappa. Chem Nat Compd. 2010;46:298–300.10.1007/s10600-010-9595-4Search in Google Scholar
8. Wang F, Li X, Sun Q, Yao S, Ke C, Tang C,et al. Sesquiterpene lactones from Inula cappa. Phytochem Lett. 2012;5:639–642.10.1016/j.phytol.2012.06.012Search in Google Scholar
9. Zou Z, Xie H, Zhang H, Xu LZ. Inositolangelates from the whole herb of Inula cappa. Fitoterapia. 2008;79:393–394.10.1016/j.fitote.2007.11.031Search in Google Scholar
10. Yesilada E, Kupeli E. Berberis crataegina DC root exhibits potent anti-inflammatory, analgesic and febrifuge effects in mice and rats. J Ethnopharmacol. 2002;79:237–248.10.1016/S0378-8741(01)00387-7Search in Google Scholar
11. Winter CA, Risley EA, Nuss GW. Anti-inflammatory and antipyretic activities of indomethacin l-{p-chlorobenzoyl}-5-methoxy-2-methyl-indole-3-acetic acid. J Pharmacol Exp Ther. 1963;141:369–376.10.1016/S0022-3565(25)26625-3Search in Google Scholar
12. DiCarlo J, Haynes LJ, Sliver NJ, Phillips GH. Reticuloendothelial system stimulants of botanical origin. J Reticuloendoth Soc. 1964;1:224–23.Search in Google Scholar
13. Nelson DS, Mildenhall P. Studies on cytophilic antibodies. The production by mice of macrophage cytophilic antibodies to sheep erythrocytes: Relationship to the production of other antibodies and development of delayed type hypersensitivity. Aust J Exp Biol Med Sci. 1967;45:113–130.10.1038/icb.1967.9Search in Google Scholar
14. Doherty NS. Selective effect of immunosuppressive agents against the delayed hypersensitivity response and humoral response to sheep red blood cells in mice. Agents Actions. 1981;11:237–242.10.1007/BF01967620Search in Google Scholar PubMed
15. Jerne NK, Nordin AA. Plaque forming in agar by single antibody producing cells. Science. 1963;140:405.10.1126/science.140.3565.405.aSearch in Google Scholar
16. Pallabi SC, Gomes A. Immunopotentiating and immunoprophylactic activities of immune 21, a polyherbal product. Indian J Pharmacol. 1998;30:163–168.Search in Google Scholar
17. Roth L, Rupp G. Roth collection of natural products data. Weinheim:VCH Verlagsgesellschaft mbH, 1995.10.1002/9783527615513Search in Google Scholar
18. Xie HG, Chen H, Chao B, Zhang HW, Zou ZM. Cytotoxic germacranolide sesquiterpene from Inula cappa. Chem Pharm Bull. 2007;55:1258–1260.10.1248/cpb.55.1258Search in Google Scholar PubMed
19. Kulinsky VI. Biochemical aspects of inflammation. Biochem. 2007;72:733–746.10.1134/S0006297907060028Search in Google Scholar
20. Kalola J, Shah M. Free radical scavenging activity of Inula cappa. Ars Pharmaceutica. 2006;47:385–401.Search in Google Scholar
21. Spector WG. The granulomatous inflammatory exudate. Int Rev Expt Pathol. 1969;8:1–55.Search in Google Scholar
22. Recio MC, Giner RM, Manez S, Ros JL. Structural requirements for the anti-inflammatory activity of natural triterpenoids. Planta Med. 1995;6:182–185.10.1055/s-2006-958045Search in Google Scholar PubMed
23. Seca A, Grigore A, Pinto D, Silva A. The genus Inula and their metabolites: From ethnopharmacological to medicinal uses. J Ethnopharmacol. 2014;154:286–310.10.1016/j.jep.2014.04.010Search in Google Scholar PubMed
24. Gasser O, Schifferli A. Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis. Blood. 2004;104:2543–2548.10.1182/blood-2004-01-0361Search in Google Scholar PubMed
25. Dua PR, Shankar G, Srimal RC, Saxena KC, Saxena RP, Puri A,et al. Adaptogenic activity of Indian panax pseudoginseng. Indian J Expt Biol. 1989;27:631–634.Search in Google Scholar
26. Puri A, Saxena RP, Saxena KC, Srivastava V, Tandon JS. Immunostimulating agents from Andrographis paniculata. J Nat Prod. 1993;56:995–999.10.1021/np50097a002Search in Google Scholar PubMed
27. Wu ZJ, Shen YH, Zhang WD. Two new phenolic glycosides from Inula cappa DC. Nat Prod Res. 2012;27:1–4.10.1080/14786419.2012.691496Search in Google Scholar
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Articles in the same Issue
- Review
- Cornus mas: a review on traditional uses and pharmacological properties
- Preclinical Studies
- Anti-inflammatory and immunomodulatory activities of Inula cappa roots (Compositae)
- Effects of water extract of Curcuma longa (L.) roots on immunity and telomerase function
- Garcinia kola seeds may prevent cognitive and motor dysfunctions in a type 1 diabetes mellitus rat model partly by mitigating neuroinflammation
- Changes in some biochemical parameters of alloxanized rats administered with varying concentrations of quail egg solution
- Ameliorative potential of Blighia sapida K.D. Koenig bark against pancreatic β-cell dysfunction in alloxan-induced diabetic rats
- Comparative evaluation of hypoglycemic and hypolipidemic activity of various extract of Anogeissus latifolia bark in streptozotocin-induced diabetic rats
- Gentiana kurroo Royle attenuates the metabolic aberrations in diabetic rats; Swertiamarin, swertisin and lupeol being the possible bioactive principles
- Biochemical and electrocardiographic studies on the beneficial effects of gallic acid in cyclophosphamide-induced cardiorenal dysfunction
- Clinical Studies
- Development and validation of a yoga module for Parkinson disease
- Case Report
- Return to work program efficacy with Self-Regulation Therapy (SRT®): Case study with complex trauma and concurrent disorders
