The effect of curcuma (Curcuma xanthorrizha roxb.) extract as an adjuvant of captopril therapy on cardiac histopathology of male mice (Mus musculus) with hypertension
-
Nursela Hijriani
,
Lilik Yusetyani
Abstract
Background
Hypertension is a cardiovascular disease which has become a major health problem in Indonesia. Left ventricle hypertrophy is one of the cardiac complications of hypertension that is characterized by thickening of the left ventricle and increasing the mass of cardiac muscle.
Methods
This study was an experimental study with a posttest group design. Twenty-four mice were divided into four groups. The normal group was given distilled water, the negative control group was given L-NAME 1.75 mg/25 g BW/day, the positive control group was given L-NAME 1.75 mg/25 g BW/day + captopril 0.04875 mg/30 g BW/day, and the adjuvant captopril group was given L-NAME 1.75 mg/25 g BW/day + captopril 0.04875 mg/30 g BW/day + curcuma extract 31.25 mg/30 g BW for 30 days.
Results
The results of one-way analysis of variance (ANOVA) test analysis on the adjuvant treatment of the captopril group revealed no significant effect on cardiac muscle mass (p > 0.05), while the thickness of the left ventricle was significant (p < 0.05).
Conclusions
Captopril-Curcuma group resulted in a decrease of cardiac muscle and the thickness of the left ventricle in male mice with hypertension.
Acknowledgments
The author thanks the Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Airlangga and Pharmacy Departement, Health Science Faculty, University of Muhammadiyah Malang.
Research funding: There is no funding in this research.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Ethical approval: Research involving animals complied with all relevant national regulations and institutional policies (Animal Research Laboratory of Faculty of Medicine, Universitas Brawijaya, Malang, Idnonesia) for the care and use of animals. The study has passed the ethical clearance from Brawijaya University on 8th July 2015 with No. 370/EC/KEPK/07/2015.
References
[1] World Health Organization. A global brief on Hypertension 2013. Available at: https://www.who.int/cardiovascular_diseases/publications/global_brief_hypertension/en/. Accessed: 1 Aug 2016.Search in Google Scholar
[2] Dasar RK. Health Research and Development Agency of the Indonesian Ministry of Health. The Head of the Indonesian Ministry of Health's Health Research and Development Agency. Jakarta, 2013.Search in Google Scholar
[3] Rhian T. New insights into mechanisms of hypertension. Curr Opin Nephrol Hypertens 2012;21:119–21.10.1097/MNH.0b013e328350a50fSearch in Google Scholar
[4] Ghonimi W, Abuel-Atta AA, Bareedy MH, Balah A. Left ventricles of the mature camel heart (Camelus dromedaries) with special references to the structure and distribution of the Purkinje cardiomyocytes: microanatomy. J Cytol Histol 2014;5:3.10.4172/2157-7579.1000183Search in Google Scholar
[5] Robbins K. Buku Ajar Patologi II Ed.4. Jakarta: Buku Kedokteran EGC, 1996:562.Search in Google Scholar
[6] Tedjasukmana P. Tata Laksana Hipertensi. Departemen Kardiologi Rumah Sakit Premier Jatinegara 2012;39:251–5.Search in Google Scholar
[7] Su JZ, Chen DG, Wu KG, Chen SC, Hu WY, Yu X, et al. Inhibitory effects of captopril on C-myc expression during left ventricular hypertrophy. Acta Pharm Sinic 1998;19:535–40.Search in Google Scholar
[8] Mary Helen PA, Susheela Gomathy K, Jayasree S, Nizzy AM, Rajagopal B, Jeeva S. Phytochemical characterization and antimicrobial activity of Curcuma xanthorrhiza Roxb. Asian Pac J Trop Biomed 2012;2:S637–40.10.1016/S2221-1691(12)60288-3Search in Google Scholar
[9] Chosdu R. Gamma radiation processing on temulawak (Curcuma xanthorrhiza Roxb) and other Zingiberaceae. Sci J Appl Isot Radiat 2008;4:2.Search in Google Scholar
[10] Kapakos G, Youreva V, Srivastava AK. Cardiovascular protection by curcumin: molecular aspect. India J Biochem Biophys 2012;49:306–15.Search in Google Scholar
[11] Sunagawa Y, Morimoto T, Wada H, Takaya T, Katanasaka Y, Kawamura T, et al. A natural p300-specific histone acetyltransferase inhibitor, curcumin, in addition to angiotensin-converting enzyme inhibitor, exerts beneficial effects on left ventricular systolic function after myocardial infraction in rats. Circ J 2011;75:2150–9.10.1253/circj.CJ-10-1072Search in Google Scholar PubMed
[12] Kukongviriyapan U, Pannangpetch P, Veerapol K, Donpunha W, Sompamit K, Surawattanawan P. Curcumin protects against cadmium-induced vascular dysfunction, hypertension and tissue cadmium accumulation in mice. Nutrients 2014;6:1194–208.10.3390/nu6031194Search in Google Scholar PubMed PubMed Central
[13] Nakmareong S, Upa K, Poungrat P, Veerapol K, Bunkerd K, Parichat P, et al. Effect of curcumin on hymedynamic status and aortic elasticity in L-NAME hypertensive rat. Srinagarid Med J 2010;25:240-2.Search in Google Scholar
[14] Ghosh MN. Fundamental of experimental pharmacology. Calcutta: Scientific Book Agency, 1971:85.Search in Google Scholar
[15] Lucia C, Shesely EG, Potter DAL, Beierwaltes WH. Cardiovascular and renal phenotype in mice with one or two renin genes. Hypertension 2008;43:79-86.10.1161/01.HYP.0000107401.72456.50Search in Google Scholar
[16] Ocsan RJ, Lai YN, Prabhu KV. Chronic NG-nitro-l-arginine methyl ester (LNAME) administration in C57BL/6 mice induces a sustained decrease in c-kit positive cells during development of cardiac hypertrophy. J Physiol Pharmacol 2013;64:727–36.Search in Google Scholar
[17] Shimatsu A, Kakeya H, Imaizumi A, Morimoto T, Kanai M, Maeda S. Clinical application of curcumin, a multi-functional substance. Anti Aging Med 2012;9:75–83.Search in Google Scholar
[18] Swamy A, Gulliaya S, Thippeswamy A, Koti B, Manjula D. Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats. Indian J Pharmacol 2012;44:1.10.4103/0253-7613.91871Search in Google Scholar PubMed PubMed Central
[19] Hartanto. Penggunaan captopril [(angiotensin converting enzyme (ACE)] pada Terapi Hipertensi 2007. Available at: https://yosefw.wordpress.com/2007/12/22/penggunaan-captopril-angiotensin-converting-enzyme-ace-inhibitor-pada-terapi-hipertensi/. Accessed: 20 Aug 2016.Search in Google Scholar
[20] Katanasaka Y, Sunagawa Y, Hasegawa K, Morimoto T. Application of curcumin to heart failure therapy by targetting transcriptional pathway in cardiomyocytes. Biol Pharm Bull 2012;36:13–7.10.1248/bpb.b212022Search in Google Scholar PubMed
[21] Li HL, Liu C, de Couto G, Ouzounian M, Sun M, Wang AB, et al. Curcumin prevents and reverses murine cardiac hypertrophy. J Clin Invest 2008;118:879-93.10.1172/JCI32865Search in Google Scholar
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