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Quercetin attenuates acute predator stress exposure-evoked innate fear and behavioral perturbation

  • Putri Anggreini , Chrismawan Ardianto , Mahardian Rahmadi and Junaidi Khotib EMAIL logo
Published/Copyright: November 28, 2019
Journal of Basic and Clinical Physiology and Pharmacology
From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 30 Issue 6

Abstract

Background

Oxidative stress plays a pivotal role in the pathophysiology and pathogenesis of mental diseases, such as depression or anxiety. Psychological stress induced by predatory stimulus is one of the models that explain how induced affective behavior is manifested as a depression-like state. Quercetin is a flavonoid that exhibits potential pharmacological activity on mental diseases. Thus, the present study was designed to investigate the effect of quercetin on innate fear and affective behavior induced by repeated predator stress exposure on mice.

Materials and methods

ICR mice were exposed to predatory stress for 3 days. Quercetin at a dose of 50 mg/kg was given intraperitoneally along with stress induction. The freezing behavior during the stress induction was analyzed. The anxiety-like and depressive-like behaviors and cognitive and motor functions were examined on the last day of induction.

Results

Predatory stress increased the affective behaviors (anxiety-like and depressive-like behaviors) and produced freezing behavior without alterations in the cognitive function and exploratory behavior. Treatment with quercetin 50 mg/kg attenuated the freezing, anxiety-like and depressive-like behaviors.

Conclusions

Repeated predator stress exposure causes both innate fear and depression-like state for the prey animals. Quercetin may have a protective effect against depression and alleviates the fear of traumatic events.

Keywords: anxiety; depression; fear; predator stress exposure; quercetin

  1. Research funding: This work was supported by research grants from the Tahir Professorship Program and PDUPT 2019 provided by the Indonesian Ministry of Research Technology and Higher Education.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: The authors state no conflict of interest.

  4. Ethical approval: All experiments were performed at the Laboratory of Animal Research, Faculty of Pharmacy, Universitas Airlangga in accordance with the guide for care and use of laboratory animals issued by National Institutes of Health revised in 1985. The protocol was approved by the ethical committee, Faculty of Veterinary, Universitas Airlangga with no. 2.KE.007.05.2019.

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Received: 2019-09-02
Accepted: 2019-10-23
Published Online: 2019-11-28

© 2019 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jbcpp-2019-0242
Keywords for this article
anxiety; depression; fear; predator stress exposure; quercetin

Articles in the same Issue

  1. Reviews
  2. Pharmacist contributions in the treatment of diabetes mellitus in Southeast Asia: a narrative review
  3. The implementation of a chronic disease management program (Prolanis) in Indonesia: a literature review
  4. Original Articles
  5. Quercetin attenuates acute predator stress exposure-evoked innate fear and behavioral perturbation
  6. Evaluating current practices and policies in the use of injectable medicines for treating myalgia in a primary care center in Pamekasan, Indonesia
  7. The contemporary role and potential of pharmacist contribution for community health using social media
  8. Evaluation of rational drug use based on World Health Organization prescribing indicators in a primary care center in Pamekasan East Java, Indonesia
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  10. Factors affecting community pharmacist’s service for women with chronic diseases during pregnancy and breastfeeding: application of the Health Belief Model
  11. Overview of therapeutic changes in antiepileptic drugs in adult patients
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  14. Correlation of chemotherapy costs with quality of life in nasopharyngeal cancer patients
  15. Impact of educational preeclampsia prevention booklet on knowledge and adherence to low dose aspirin among pregnant women with high risk for preeclampsia
  16. Translation, cultural adaptation, and validation of the quality of well being self-administered questionnaire in general population in Indonesia
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  18. Medication adherence in diabetes mellitus patients at Tanjung Karang Primary Health Care Center, Mataram
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  20. Antiaggregation effect of clopidogrel in coronary heart disease patients using omeprazole
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