Correlation of chemotherapy costs with quality of life in nasopharyngeal cancer patients
-
Achmad Chusnu Romdhoni
,
Ririn Prasetyo Utaminingtyas
Abstract
Background
Nasopharyngeal cancer (NPC) is the most common neck/head cancer occurring in Indonesia and is the fourth most malignant after breast cancer, cervical cancer, and lung cancer. It is known that the cost of chemotherapy may not be separated from quality of life (QoL) to reflect the success of therapy, especially in cancer patients. Thus, studies on the correlation between chemotherapy cost and the QoL in NPC patients are needed.
Methods
The participants were recruited by a consecutive sampling method. All patients diagnosed with NPC using a paclitaxel-cisplatin chemotherapy regimen in August–March 2019 for first until the third chemotherapy cycle were assessed for their the chemotherapy cost and QoL before the first chemotherapy cycle and after the third cycle using the EORTC QLQ-C30 questionnaire. Chemotherapy cost and QoL were analyzed using SPSS version 20 to find out the correlation.
Results
Data from 26 patients showed a notable increase in the QoL after the third chemotherapy cycle. Thus, there was a relationship between chemotherapy cost and QoL in NPC patients. The total cost of chemotherapy increased with the increase in cycles of chemotherapy. We further analyzed the correlation between QoL and the cost of chemotherapy. We found that there was a correlation between the cost and the aspects of global health status, the QoL.
Conclusions
It is concluded that chemotherapy that is followed by the increase in cost in chemotherapy improves the QoL.
Acknowledgment
The author thanks the Department of Clinical Pharmacy, Faculty of Pharmacy, UniversitasAirlangga and RSUD Dr. Soetomo.
Research funding: This research was funded by Riset Unggulan Perumahsakitan RSUD Dr. Soetomo.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: Research involving human complied with all relevant national regulations and institutional policies. This research has been declared eligible by the ethics committee of Hospital Dr. Soetomo on August 8, 2018 under number 0471/KEPK/VIII/2018.
References
[1] Dinkes SBY. Prof. Sun Kanker Nasofaring Keganasan yang Tersembunyi. 2018. Available at: http://dinkes.surabaya.go.id/portal/berita/prof-sun-kanker-nasofaring-keganasan-yang-tersembunyi/.Search in Google Scholar
[2] Kemenkes RI. Panduan Penatalaksanaan Kanker Nasofaring. Jakarta: Kementrian Kesehatan Republik, 2017.Search in Google Scholar
[3] BCCA. Monograph: Cisplatin. BC Cancer Agency Drug Monograph. BC Cancer Agency, 2016;1–11.Search in Google Scholar
[4] BCCA. Monograph: Paclitaxel. BC Cancer Agency Drug Monograph. BC Cancer Agency, 2016;1–10.Search in Google Scholar
[5] Cengiz M, Ozyar E, Esassolak M, Altun M, Akmansu M, Sen M, et al. Assessment of quality life of nasopharyngeal carcinoma patients with EORTC QLQ C30 and H&N 30: Turkish Oncology Group, Head and Neck Working Party Study. Internat J Radiation Oncol 2004;60:558.10.1016/j.ijrobp.2004.07.558Search in Google Scholar
[6] Salehiniya H, Mohammadian M, Hafshejanu M, Mahdaviar N. Nasopharyngeal cancer in the world: epidemiology, incidence, mortality and risk factor. World Cancer Res J 2018;5:1046–53.10.15419/bmrat.v5i6.447Search in Google Scholar
[7] Depkes. Deteksi Kanker Leher Rahim dan Kanker Payudara. 2018. Available at: http://depkes.go.id.Search in Google Scholar
[8] Permenkes. Peraturan Menteri Kesehatan Republik Indonesia Nomor 76 Tahun 2016 Tentang Pedoman Indonesian Case Base Groups (INA-CBG’s) dalam Pelaksanaan Jaminan Kesehatan Nasional. Kementrian Kesehatan RI. 2016.Search in Google Scholar
[9] Maniadakis N, Dafni U, Fragoulakis V, Grimani I, Galani E, Fragkoulidi A, et al. Economic evaluation of taxane-based first line chemotherapy in the treatment of patients with metastatic breast cancer in Greece: an analysis alongside a multicenter, randomized phase III clinical trial. Ann Oncol 2009;20:278–85.10.1093/annonc/mdn634Search in Google Scholar PubMed
[10] McCloskey W. Principles of drug literature evaluation dalam Vogenburg, F. R., introduction to applied pharmacoeconomics. New York: McGraw Hill Company, 2001.Search in Google Scholar
[11] Perwitasari DA, Atthobari J, Dwiprahasto I, Hakimi M, Gelderblom H, Putter H, et al. Translation and validation of EORTC QLQ-C30 into indonesian version for cancer patients in Indonesia. Jap J Clin Oncol 2011;42:519–29.10.1093/jjco/hyq243Search in Google Scholar PubMed
[12] Wei IW. Nasopharyngeal Cancer. In: Byron B, Johnson, Jonas T, Newlands, Shawn D. Head & neck surgery – otolaryngology, 4th ed. Lippincott, USA: Williams & Wilkins, 2006;35–79.Search in Google Scholar
[13] Adham M, Kurniawan A. Nasopharingeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation. Chin J Cancer 2016;3:185–6.Search in Google Scholar
[14] Chan J, PIlch B, Kuo T, Wenig B, Lee A. Tumours of the nasopharynx. In: Barnes L, EJRPSD, editor. WHO classification of tumours: head and neck tumours. Lyon: IARC Press, 2005:81–106.Search in Google Scholar
[15] Centers for Disease Control. Health-Related Quality of Life. USA; 2016. Available at: https://www.cdc.gov/hrqol/concept.htm. Accessed: Dec 2018.Search in Google Scholar
[16] Blond BN, Detyniecki K, Hirrsch K. Assesment of treatment side effects and quality of live in people with epilepsy. Elsevier 2015;15:733–819.Search in Google Scholar
[17] NCCN. Clinical practice guidelines in oncology: head and neck cancers. USA; 2016;1.Search in Google Scholar
[18] Hays RD, Morales LS. The RAND-36 measure of health-related quality of life. Ann Med 2001;33:350–7.10.3109/07853890109002089Search in Google Scholar PubMed
[19] Brandwein MS. Textbook of head and neck pathology: Volume 1 nose, paranasal sinuses, and nasopharynx. Switzerland: Springer, 2016.10.1007/978-3-319-33323-6Search in Google Scholar
[20] Aaranson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European organisation for research and treatment of cancer QLQ-C30: quality of life instrument for use in international clinical trials in oncology. J Nat Cancer Inst 1993;85:365–76.10.1093/jnci/85.5.365Search in Google Scholar PubMed
[21] Saad S, Wang TJ. Nasopharyngeal carcinoma: current treatment options and future directions. J Nasopharyng Carcinoma 2014;16:1–16.Search in Google Scholar
[22] Skrepnek Grant H. Cost-effectiveness analysis. In: Lyle BJ, Townsend Raymond J, McGhan William F, editors. Principles of pharmacoeconomics, 3rd ed. Harvey Whitney Books Company, 1991:120–46.Search in Google Scholar
© 2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Reviews
- Pharmacist contributions in the treatment of diabetes mellitus in Southeast Asia: a narrative review
- The implementation of a chronic disease management program (Prolanis) in Indonesia: a literature review
- Original Articles
- Quercetin attenuates acute predator stress exposure-evoked innate fear and behavioral perturbation
- Evaluating current practices and policies in the use of injectable medicines for treating myalgia in a primary care center in Pamekasan, Indonesia
- The contemporary role and potential of pharmacist contribution for community health using social media
- Evaluation of rational drug use based on World Health Organization prescribing indicators in a primary care center in Pamekasan East Java, Indonesia
- The prescription patterns of second-generation antipsychotics in schizophrenia outpatient setting
- Factors affecting community pharmacist’s service for women with chronic diseases during pregnancy and breastfeeding: application of the Health Belief Model
- Overview of therapeutic changes in antiepileptic drugs in adult patients
- Exploration of barriers affecting job satisfaction among community pharmacists
- Patients’ characteristics and their adherence to insulin therapy
- Correlation of chemotherapy costs with quality of life in nasopharyngeal cancer patients
- Impact of educational preeclampsia prevention booklet on knowledge and adherence to low dose aspirin among pregnant women with high risk for preeclampsia
- Translation, cultural adaptation, and validation of the quality of well being self-administered questionnaire in general population in Indonesia
- Knowledge, attitude, and practice of pharmacists towards management of hypertension in primary care centers
- Medication adherence in diabetes mellitus patients at Tanjung Karang Primary Health Care Center, Mataram
- Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2
- Antiaggregation effect of clopidogrel in coronary heart disease patients using omeprazole
- The effect of curcuma (Curcuma xanthorrizha roxb.) extract as an adjuvant of captopril therapy on cardiac histopathology of male mice (Mus musculus) with hypertension
- Coenzyme Q10 nanostructured lipid carriers as an inducer of the skin fibroblast cell and its irritability test in a mice model
- Medical problems in patients with chronic kidney disease undergoing hemodialysis and their therapy
- ADMET properties of novel 5-O-benzoylpinostrobin derivatives
- Development of nonalcoholic fatty liver disease model by high-fat diet in rats
- Molecular docking of novel 5-O-benzoylpinostrobin derivatives as wild type and L858R/T790M/V948R mutant EGFR inhibitor
- The relationship between the level of education and accuracy of insulin injection techniques in DM patients with measurement of HbA1c values
- The effect of premixed insulin to blood glucose concentration in patients with type 2 diabetes mellitus
- Intravenous insulin therapy in diabetes mellitus with hyperglycemic crisis and intercurrent illness
- Adherence behavior assessment of oral antidiabetic medication use: a study of patient decisions in long-term disease management in primary health care centers in Surabaya
- Evaluation to the chemotherapy use in patients with diffuse large B-cell lymphoma
- Analysis of the use and cost of stress ulcer prophylaxis for surgical inpatients
- Antineuroinflammation activity of n-butanol fraction of Marsilea crenata Presl. in microglia HMC3 cell line
- The enhancement of Arg1 and activated ERβ expression in microglia HMC3 by induction of 96% ethanol extract of Marsilea crenata Presl. leaves
- Ternary solid dispersion to improve solubility and dissolution of meloxicam
- Improving solubility and dissolution of meloxicam by solid dispersion using hydroxypropyl methylcellulose 2910 3 cps and nicotinamide
- o-Hydroxycinnamic derivatives as prospective anti-platelet candidates: in silico pharmacokinetic screening and evaluation of their binding sites on COX-1 and P2Y12 receptors
- The change of proinflammatory cytokine tumor necrosis factor α level in the use of meloxicam in rat model of osteoarthritis
- Attenuation of IL-1ß on the use of glucosamine as an adjuvant in meloxicam treatment in rat models with osteoarthritis
- Analysis of effectiveness and drug related problems of pain reliever for knee osteoarthritis: weighing clinical risk and benefit
- Comparison of antibiotic prescriptions in adults and children with upper respiratory tract infections in Bangka Tengah primary health care centers
- Profile of sociodemographics, sources of infection, antiretrovirals and CD4 counts on HIV/AIDS outpatients in Turen Primary Health Centre, Indonesia
- Synergistic anti-hepatitis C virus activity of Ruta angustifolia extract with NS3 protein inhibitor
- In vitro equivalence of generic and branded amoxicillin tablet by microbiological assay method
- Knowledge and attitude: two fundamental factors that determine patient compliance in antibiotic therapy
- Molecular docking study of sappan wood extract to inhibit PBP2A enzyme on methicillin-resistant Staphylococcus aureus (MRSA)
- Effect of curcumin analogue synthetic product from cullilawan oil for the liver damage treatment in male mice (Mus musculus L.)
- Case Report
- A case report of generalized tetanus in a 42-year-old man with dental infection
Articles in the same Issue
- Reviews
- Pharmacist contributions in the treatment of diabetes mellitus in Southeast Asia: a narrative review
- The implementation of a chronic disease management program (Prolanis) in Indonesia: a literature review
- Original Articles
- Quercetin attenuates acute predator stress exposure-evoked innate fear and behavioral perturbation
- Evaluating current practices and policies in the use of injectable medicines for treating myalgia in a primary care center in Pamekasan, Indonesia
- The contemporary role and potential of pharmacist contribution for community health using social media
- Evaluation of rational drug use based on World Health Organization prescribing indicators in a primary care center in Pamekasan East Java, Indonesia
- The prescription patterns of second-generation antipsychotics in schizophrenia outpatient setting
- Factors affecting community pharmacist’s service for women with chronic diseases during pregnancy and breastfeeding: application of the Health Belief Model
- Overview of therapeutic changes in antiepileptic drugs in adult patients
- Exploration of barriers affecting job satisfaction among community pharmacists
- Patients’ characteristics and their adherence to insulin therapy
- Correlation of chemotherapy costs with quality of life in nasopharyngeal cancer patients
- Impact of educational preeclampsia prevention booklet on knowledge and adherence to low dose aspirin among pregnant women with high risk for preeclampsia
- Translation, cultural adaptation, and validation of the quality of well being self-administered questionnaire in general population in Indonesia
- Knowledge, attitude, and practice of pharmacists towards management of hypertension in primary care centers
- Medication adherence in diabetes mellitus patients at Tanjung Karang Primary Health Care Center, Mataram
- Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2
- Antiaggregation effect of clopidogrel in coronary heart disease patients using omeprazole
- The effect of curcuma (Curcuma xanthorrizha roxb.) extract as an adjuvant of captopril therapy on cardiac histopathology of male mice (Mus musculus) with hypertension
- Coenzyme Q10 nanostructured lipid carriers as an inducer of the skin fibroblast cell and its irritability test in a mice model
- Medical problems in patients with chronic kidney disease undergoing hemodialysis and their therapy
- ADMET properties of novel 5-O-benzoylpinostrobin derivatives
- Development of nonalcoholic fatty liver disease model by high-fat diet in rats
- Molecular docking of novel 5-O-benzoylpinostrobin derivatives as wild type and L858R/T790M/V948R mutant EGFR inhibitor
- The relationship between the level of education and accuracy of insulin injection techniques in DM patients with measurement of HbA1c values
- The effect of premixed insulin to blood glucose concentration in patients with type 2 diabetes mellitus
- Intravenous insulin therapy in diabetes mellitus with hyperglycemic crisis and intercurrent illness
- Adherence behavior assessment of oral antidiabetic medication use: a study of patient decisions in long-term disease management in primary health care centers in Surabaya
- Evaluation to the chemotherapy use in patients with diffuse large B-cell lymphoma
- Analysis of the use and cost of stress ulcer prophylaxis for surgical inpatients
- Antineuroinflammation activity of n-butanol fraction of Marsilea crenata Presl. in microglia HMC3 cell line
- The enhancement of Arg1 and activated ERβ expression in microglia HMC3 by induction of 96% ethanol extract of Marsilea crenata Presl. leaves
- Ternary solid dispersion to improve solubility and dissolution of meloxicam
- Improving solubility and dissolution of meloxicam by solid dispersion using hydroxypropyl methylcellulose 2910 3 cps and nicotinamide
- o-Hydroxycinnamic derivatives as prospective anti-platelet candidates: in silico pharmacokinetic screening and evaluation of their binding sites on COX-1 and P2Y12 receptors
- The change of proinflammatory cytokine tumor necrosis factor α level in the use of meloxicam in rat model of osteoarthritis
- Attenuation of IL-1ß on the use of glucosamine as an adjuvant in meloxicam treatment in rat models with osteoarthritis
- Analysis of effectiveness and drug related problems of pain reliever for knee osteoarthritis: weighing clinical risk and benefit
- Comparison of antibiotic prescriptions in adults and children with upper respiratory tract infections in Bangka Tengah primary health care centers
- Profile of sociodemographics, sources of infection, antiretrovirals and CD4 counts on HIV/AIDS outpatients in Turen Primary Health Centre, Indonesia
- Synergistic anti-hepatitis C virus activity of Ruta angustifolia extract with NS3 protein inhibitor
- In vitro equivalence of generic and branded amoxicillin tablet by microbiological assay method
- Knowledge and attitude: two fundamental factors that determine patient compliance in antibiotic therapy
- Molecular docking study of sappan wood extract to inhibit PBP2A enzyme on methicillin-resistant Staphylococcus aureus (MRSA)
- Effect of curcumin analogue synthetic product from cullilawan oil for the liver damage treatment in male mice (Mus musculus L.)
- Case Report
- A case report of generalized tetanus in a 42-year-old man with dental infection
