Effect of curcumin analogue synthetic product from cullilawan oil for the liver damage treatment in male mice (Mus musculus L.)
-
Imanuel Berly Delvis Kapelle
,
Wasmen Manalu
Abstract
The active component in cullilawan oil can be synthesized into curcumin analogue product, which has pharmacological activity. The synthesis process by using conventional and microwave methods can produce different isomer products. Different synthesis products and models of animal are used to provide different hepatoprotective effects. The aim of this study was to use the curcumin analogue synthetic products (AKS-k and AKS-m) from cullilawan oil in male mice (Mus musculus L.) liver damage treatment induced by carbon tetrachloride (CCl4). The in vivo method was employed using biochemical of blood and histopathological images of liver cells as indicators. The results showed that the curcumin analogue synthetic product using microwave methods had better pharmacological effects than the conventional method product in terms of the results of blood biochemical analysis and microscopic images of liver cells.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Research funding: This research fund is supported by Directorate of Research and Community Service, The Ministry of Research, Technology, and Higher Education for giving Research Post-Doctoral.
Competing interests: The authors state no conflict of interest.
Ethical approval: Research involving animals complied with all relevant national regulations and institutional policies for the care and use of animals (614/ETIK2019).
References
[1] Kapelle IB, Irawadi TT, Rusli MS, Mangunwidjaja D, Mas’ud ZA. Rekayasa Proses Sintesis Piperonal Kulit Lawang (Cinnamomum cullilawan Blume) Sebagai Prekursor Obat Kanker. Jurnal Penelitian Hasil Hutan 2016;34:217–29.10.20886/jphh.2016.34.3.217-229Search in Google Scholar
[2] Kapelle IB, Irawadi TT, Rusli MS, Mangunwidjaja D, Mas’ud ZA. Synthesis of new curcumin analogs from kulit lawang oils using the conventional method and microwave. Sci J Chem 2015;3:50–6.10.11648/j.sjc.20150303.13Search in Google Scholar
[3] Kapelle IB, Irawadi TT, Rusli MS, Mangunwidjaja D, Mas’ud ZA. Synthesis of asymmetric curcumin analogs from cullilawan oil using conventional and microwave method. Procedia Chem 2015;16:480–8.10.1016/j.proche.2015.12.082Search in Google Scholar
[4] Kapelle IB, Irawadi TT, Rusli MS, Mangunwidjaja D, Mas’ud ZA. The influence of synthesis methods against anti-cancer activity of curcumin analogous. Cancer Res J 2015;3:68–75.10.11648/j.crj.20150304.12Search in Google Scholar
[5] Yang CH, Yue J, Sims M, Pfeffer LM. The curcumin analog EF24 targets NF-kB and miRNA-21, and has potent anticancer activity in vitro and in vivo. PLoS One 2013;8:e71130.10.1371/journal.pone.0071130Search in Google Scholar PubMed PubMed Central
[6] Johnson JJ, Mukhtar H. Curcumin for chemoprevention of colon cancer. Cancer Let 2007;255:170–81.10.1016/j.canlet.2007.03.005Search in Google Scholar PubMed
[7] Khan RA, Khan MR, Ahmed M, Sahreen S, Shah NA, Shah MS, et al. Hepatoprotection with a chloroform extract of Launaea procumbens against CCl4-induced injuries in rats. BMC Complement Altern Med 2012;12:114.10.1186/1472-6882-12-114Search in Google Scholar PubMed PubMed Central
[8] Kapelle IB, Manalu W. The preventive effect of curcumin analogs (AKS-k) from cullilawan oil as hepatoprotector in rats (Rattus norvegicus L.) induced by CCl4. IJPSAT 2018;11:81–5.Search in Google Scholar
[9] Burt AD, Portmann BC, Ferrel LB. Pathology of the liver, 5th ed. New York: Churchill Livingstone, 2007.Search in Google Scholar
[11] Ruhu P, McDonald R. Use of antioxidant nutrient in the prevention and treatment of type 2 diabetes. J Am Coll Nutr 2001;20:363–9.10.1080/07315724.2001.10719169Search in Google Scholar PubMed
[13] Calce E, Bugatti V, Vittoria V, De Luca S. Solvent-free synthesis of modified pectin compounds promoted by microwave irradiation. Molecules 2012;17:12234–42.10.3390/molecules171012234Search in Google Scholar PubMed PubMed Central
[14] Al-Mousawi SM, El-Apasery MA, Elnagdi MH. Microwave assisted dyeing of polyester fabrics with disperse dyes. Molecules 2013;18:11033–43.10.3390/molecules180911033Search in Google Scholar PubMed PubMed Central
[15] Motoo T. Relative stability of cis- and trans-hydrindanones. Molecules 2015;20:1509–18.10.3390/molecules20011509Search in Google Scholar PubMed PubMed Central
[16] Hickey T, Claffey J, Fitzpatrick E, Hogan M, Pampillón C, Tacke M. Dimethylamino-functionalised and N-heteroaryl-substituted titanocene anticancer drugs: synthesis and cytotoxicity studies. Invest New Drugs 2007;25:425–33.10.1007/s10637-007-9061-8Search in Google Scholar PubMed
[17] Lullman H, Lutz H, Klaus M, Detlef B. Color atlas of pharmacology, 3rd ed, revised and expanded. Stuttgart and New York: Thieme, 2005.Search in Google Scholar
© 2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Reviews
- Pharmacist contributions in the treatment of diabetes mellitus in Southeast Asia: a narrative review
- The implementation of a chronic disease management program (Prolanis) in Indonesia: a literature review
- Original Articles
- Quercetin attenuates acute predator stress exposure-evoked innate fear and behavioral perturbation
- Evaluating current practices and policies in the use of injectable medicines for treating myalgia in a primary care center in Pamekasan, Indonesia
- The contemporary role and potential of pharmacist contribution for community health using social media
- Evaluation of rational drug use based on World Health Organization prescribing indicators in a primary care center in Pamekasan East Java, Indonesia
- The prescription patterns of second-generation antipsychotics in schizophrenia outpatient setting
- Factors affecting community pharmacist’s service for women with chronic diseases during pregnancy and breastfeeding: application of the Health Belief Model
- Overview of therapeutic changes in antiepileptic drugs in adult patients
- Exploration of barriers affecting job satisfaction among community pharmacists
- Patients’ characteristics and their adherence to insulin therapy
- Correlation of chemotherapy costs with quality of life in nasopharyngeal cancer patients
- Impact of educational preeclampsia prevention booklet on knowledge and adherence to low dose aspirin among pregnant women with high risk for preeclampsia
- Translation, cultural adaptation, and validation of the quality of well being self-administered questionnaire in general population in Indonesia
- Knowledge, attitude, and practice of pharmacists towards management of hypertension in primary care centers
- Medication adherence in diabetes mellitus patients at Tanjung Karang Primary Health Care Center, Mataram
- Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2
- Antiaggregation effect of clopidogrel in coronary heart disease patients using omeprazole
- The effect of curcuma (Curcuma xanthorrizha roxb.) extract as an adjuvant of captopril therapy on cardiac histopathology of male mice (Mus musculus) with hypertension
- Coenzyme Q10 nanostructured lipid carriers as an inducer of the skin fibroblast cell and its irritability test in a mice model
- Medical problems in patients with chronic kidney disease undergoing hemodialysis and their therapy
- ADMET properties of novel 5-O-benzoylpinostrobin derivatives
- Development of nonalcoholic fatty liver disease model by high-fat diet in rats
- Molecular docking of novel 5-O-benzoylpinostrobin derivatives as wild type and L858R/T790M/V948R mutant EGFR inhibitor
- The relationship between the level of education and accuracy of insulin injection techniques in DM patients with measurement of HbA1c values
- The effect of premixed insulin to blood glucose concentration in patients with type 2 diabetes mellitus
- Intravenous insulin therapy in diabetes mellitus with hyperglycemic crisis and intercurrent illness
- Adherence behavior assessment of oral antidiabetic medication use: a study of patient decisions in long-term disease management in primary health care centers in Surabaya
- Evaluation to the chemotherapy use in patients with diffuse large B-cell lymphoma
- Analysis of the use and cost of stress ulcer prophylaxis for surgical inpatients
- Antineuroinflammation activity of n-butanol fraction of Marsilea crenata Presl. in microglia HMC3 cell line
- The enhancement of Arg1 and activated ERβ expression in microglia HMC3 by induction of 96% ethanol extract of Marsilea crenata Presl. leaves
- Ternary solid dispersion to improve solubility and dissolution of meloxicam
- Improving solubility and dissolution of meloxicam by solid dispersion using hydroxypropyl methylcellulose 2910 3 cps and nicotinamide
- o-Hydroxycinnamic derivatives as prospective anti-platelet candidates: in silico pharmacokinetic screening and evaluation of their binding sites on COX-1 and P2Y12 receptors
- The change of proinflammatory cytokine tumor necrosis factor α level in the use of meloxicam in rat model of osteoarthritis
- Attenuation of IL-1ß on the use of glucosamine as an adjuvant in meloxicam treatment in rat models with osteoarthritis
- Analysis of effectiveness and drug related problems of pain reliever for knee osteoarthritis: weighing clinical risk and benefit
- Comparison of antibiotic prescriptions in adults and children with upper respiratory tract infections in Bangka Tengah primary health care centers
- Profile of sociodemographics, sources of infection, antiretrovirals and CD4 counts on HIV/AIDS outpatients in Turen Primary Health Centre, Indonesia
- Synergistic anti-hepatitis C virus activity of Ruta angustifolia extract with NS3 protein inhibitor
- In vitro equivalence of generic and branded amoxicillin tablet by microbiological assay method
- Knowledge and attitude: two fundamental factors that determine patient compliance in antibiotic therapy
- Molecular docking study of sappan wood extract to inhibit PBP2A enzyme on methicillin-resistant Staphylococcus aureus (MRSA)
- Effect of curcumin analogue synthetic product from cullilawan oil for the liver damage treatment in male mice (Mus musculus L.)
- Case Report
- A case report of generalized tetanus in a 42-year-old man with dental infection
Articles in the same Issue
- Reviews
- Pharmacist contributions in the treatment of diabetes mellitus in Southeast Asia: a narrative review
- The implementation of a chronic disease management program (Prolanis) in Indonesia: a literature review
- Original Articles
- Quercetin attenuates acute predator stress exposure-evoked innate fear and behavioral perturbation
- Evaluating current practices and policies in the use of injectable medicines for treating myalgia in a primary care center in Pamekasan, Indonesia
- The contemporary role and potential of pharmacist contribution for community health using social media
- Evaluation of rational drug use based on World Health Organization prescribing indicators in a primary care center in Pamekasan East Java, Indonesia
- The prescription patterns of second-generation antipsychotics in schizophrenia outpatient setting
- Factors affecting community pharmacist’s service for women with chronic diseases during pregnancy and breastfeeding: application of the Health Belief Model
- Overview of therapeutic changes in antiepileptic drugs in adult patients
- Exploration of barriers affecting job satisfaction among community pharmacists
- Patients’ characteristics and their adherence to insulin therapy
- Correlation of chemotherapy costs with quality of life in nasopharyngeal cancer patients
- Impact of educational preeclampsia prevention booklet on knowledge and adherence to low dose aspirin among pregnant women with high risk for preeclampsia
- Translation, cultural adaptation, and validation of the quality of well being self-administered questionnaire in general population in Indonesia
- Knowledge, attitude, and practice of pharmacists towards management of hypertension in primary care centers
- Medication adherence in diabetes mellitus patients at Tanjung Karang Primary Health Care Center, Mataram
- Decreasing angiogenesis vasa vasorum through Lp-PLA2 and H2O2 inhibition by PSP from Ganoderma lucidum in atherosclerosis: in vivo diabetes mellitus type 2
- Antiaggregation effect of clopidogrel in coronary heart disease patients using omeprazole
- The effect of curcuma (Curcuma xanthorrizha roxb.) extract as an adjuvant of captopril therapy on cardiac histopathology of male mice (Mus musculus) with hypertension
- Coenzyme Q10 nanostructured lipid carriers as an inducer of the skin fibroblast cell and its irritability test in a mice model
- Medical problems in patients with chronic kidney disease undergoing hemodialysis and their therapy
- ADMET properties of novel 5-O-benzoylpinostrobin derivatives
- Development of nonalcoholic fatty liver disease model by high-fat diet in rats
- Molecular docking of novel 5-O-benzoylpinostrobin derivatives as wild type and L858R/T790M/V948R mutant EGFR inhibitor
- The relationship between the level of education and accuracy of insulin injection techniques in DM patients with measurement of HbA1c values
- The effect of premixed insulin to blood glucose concentration in patients with type 2 diabetes mellitus
- Intravenous insulin therapy in diabetes mellitus with hyperglycemic crisis and intercurrent illness
- Adherence behavior assessment of oral antidiabetic medication use: a study of patient decisions in long-term disease management in primary health care centers in Surabaya
- Evaluation to the chemotherapy use in patients with diffuse large B-cell lymphoma
- Analysis of the use and cost of stress ulcer prophylaxis for surgical inpatients
- Antineuroinflammation activity of n-butanol fraction of Marsilea crenata Presl. in microglia HMC3 cell line
- The enhancement of Arg1 and activated ERβ expression in microglia HMC3 by induction of 96% ethanol extract of Marsilea crenata Presl. leaves
- Ternary solid dispersion to improve solubility and dissolution of meloxicam
- Improving solubility and dissolution of meloxicam by solid dispersion using hydroxypropyl methylcellulose 2910 3 cps and nicotinamide
- o-Hydroxycinnamic derivatives as prospective anti-platelet candidates: in silico pharmacokinetic screening and evaluation of their binding sites on COX-1 and P2Y12 receptors
- The change of proinflammatory cytokine tumor necrosis factor α level in the use of meloxicam in rat model of osteoarthritis
- Attenuation of IL-1ß on the use of glucosamine as an adjuvant in meloxicam treatment in rat models with osteoarthritis
- Analysis of effectiveness and drug related problems of pain reliever for knee osteoarthritis: weighing clinical risk and benefit
- Comparison of antibiotic prescriptions in adults and children with upper respiratory tract infections in Bangka Tengah primary health care centers
- Profile of sociodemographics, sources of infection, antiretrovirals and CD4 counts on HIV/AIDS outpatients in Turen Primary Health Centre, Indonesia
- Synergistic anti-hepatitis C virus activity of Ruta angustifolia extract with NS3 protein inhibitor
- In vitro equivalence of generic and branded amoxicillin tablet by microbiological assay method
- Knowledge and attitude: two fundamental factors that determine patient compliance in antibiotic therapy
- Molecular docking study of sappan wood extract to inhibit PBP2A enzyme on methicillin-resistant Staphylococcus aureus (MRSA)
- Effect of curcumin analogue synthetic product from cullilawan oil for the liver damage treatment in male mice (Mus musculus L.)
- Case Report
- A case report of generalized tetanus in a 42-year-old man with dental infection
